PMID- 31389118
OWN - NLM
STAT- MEDLINE
DCOM- 20200724
LR  - 20200724
IS  - 1099-1557 (Electronic)
IS  - 1053-8569 (Linking)
VI  - 28
IP  - 11
DP  - 2019 Nov
TI  - NSAID use among residents in 68 residential aged care facilities 2014 to 2017: An 
      analysis of duration, concomitant medication use, and high-risk conditions.
PG  - 1480-1488
LID - 10.1002/pds.4866 [doi]
AB  - PURPOSE: People in residential aged care are at increased risk of adverse events 
      from nonsteroidal anti-inflammatory drugs (NSAIDs) due to their age and health 
      status, but little is known about use of NSAIDs in this setting. We aimed to 
      estimate the prevalence of NSAID use by route, differences by high-risk 
      conditions, prevalence of concurrent proton pump inhibitor (PPI) use, and 
      prevalence of the "triple whammy" combination (oral NSAID, diuretic, and 
      angiotensin-converting-enzyme inhibitor or angiotensin receptor antagonist). 
      METHODS: We conducted a dynamic cohort study using medication administration data 
      from 68 residential aged care facilities (RACFs) during 2014 to 2017. Descriptive 
      statistics and regression were used to estimate the proportion of residents who 
      used NSAIDs, NSAIDs long term, NSAIDs with PPIs, and the triple whammy 
      combination. RESULTS: Ten thousand three hundred sixty-seven residents were 
      included. Two thousand four hundred fourteen (23.3%) used at least one NSAID: 756 
      (7.3%) used only oral, 1326 (12.8%) used only topical, and 332 (3.2%) used both 
      topical and oral NSAIDs. One thousand five hundred forty two (14.8%) used an 
      NSAID long term, a majority of which only used topical NSAIDs 933/1542 (60.5%). 
      Age, sex, and health status were associated with greater variation in long-term 
      topical use relative to oral NSAID use. A majority of oral NSAID users 
      concomitantly used a PPI, which varied according to age, sex, and health status. 
      Among residents with any oral NSAID use, 182/1088 (16.7%) had triple whammy 
      medication use. CONCLUSIONS: Targeted interventions to reduce NSAID use among 
      RACF residents, to reduce triple whammy medication use, and increase PPI use for 
      long-term oral NSAID users are warranted.
CI  - (c) 2019 John Wiley & Sons, Ltd.
FAU - Lind, Kimberly E
AU  - Lind KE
AUID- ORCID: 0000-0002-8850-1576
AD  - Centre for Health Systems and Safety Research, Australian Institute of Health 
      Innovation, Macquarie University, Sydney, New South Wales, Australia.
FAU - Raban, Magdalena Z
AU  - Raban MZ
AD  - Centre for Health Systems and Safety Research, Australian Institute of Health 
      Innovation, Macquarie University, Sydney, New South Wales, Australia.
FAU - Georgiou, Andrew
AU  - Georgiou A
AUID- ORCID: 0000-0002-7619-3668
AD  - Centre for Health Systems and Safety Research, Australian Institute of Health 
      Innovation, Macquarie University, Sydney, New South Wales, Australia.
FAU - Westbrook, Johanna I
AU  - Westbrook JI
AD  - Centre for Health Systems and Safety Research, Australian Institute of Health 
      Innovation, Macquarie University, Sydney, New South Wales, Australia.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20190806
PL  - England
TA  - Pharmacoepidemiol Drug Saf
JT  - Pharmacoepidemiology and drug safety
JID - 9208369
RN  - 0 (Angiotensin Receptor Antagonists)
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Diuretics)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Administration, Oral
MH  - Administration, Topical
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiotensin Receptor Antagonists/administration & dosage
MH  - Angiotensin-Converting Enzyme Inhibitors/administration & dosage
MH  - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage/adverse effects
MH  - Cohort Studies
MH  - Diuretics/administration & dosage
MH  - Female
MH  - Homes for the Aged/*statistics & numerical data
MH  - Humans
MH  - Male
MH  - Nursing Homes/*statistics & numerical data
MH  - Proton Pump Inhibitors/*administration & dosage
MH  - Retrospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - NSAID
OT  - long-term care
OT  - nonsteroidal anti-inflammatory drugs
OT  - pharmacoepidemiology
OT  - triple whammy
EDAT- 2019/08/08 06:00
MHDA- 2020/07/25 06:00
CRDT- 2019/08/08 06:00
PHST- 2019/01/16 00:00 [received]
PHST- 2019/06/06 00:00 [revised]
PHST- 2019/07/02 00:00 [accepted]
PHST- 2019/08/08 06:00 [pubmed]
PHST- 2020/07/25 06:00 [medline]
PHST- 2019/08/08 06:00 [entrez]
AID - 10.1002/pds.4866 [doi]
PST - ppublish
SO  - Pharmacoepidemiol Drug Saf. 2019 Nov;28(11):1480-1488. doi: 10.1002/pds.4866. 
      Epub 2019 Aug 6.