PMID- 31389507
OWN - NLM
STAT- MEDLINE
DCOM- 20190812
LR  - 20190812
IS  - 1806-9282 (Electronic)
IS  - 0104-4230 (Linking)
VI  - 65
IP  - 7
DP  - 2019 Aug 5
TI  - Relationship of T lymphocytes, cytokines, immunoglobulin E and nitric oxide with 
      otitis media with effusion in children and their clinical significances.
PG  - 971-976
LID - S0104-42302019000700971 [pii]
LID - 10.1590/1806-9282.65.7.971 [doi]
AB  - OBJECTIVE: To investigate the relations of T lymphocytes, cytokines, 
      immunoglobulin E, and nitric oxide with otitis media with effusion (OME) in 
      children and their clinical significances. METHODS: Fifty children with OME 
      treated in our hospital were enrolled in the study (observation group). Fifty 
      healthy children were selected as control. The percentages of CD4+ and CD8+ T 
      lymphocyte and CD4+/CD8+ ratio in peripheral blood, and the levels of cytokine 
      (IL)-2, IL-4, IL-6, immunoglobulin E (IgE) and nitric oxide (NO) in peripheral 
      blood and middle ear effusion (MEE) in both groups were detected. The 
      correlations of these indexes with OME were analyzed. RESULTS: The percentage of 
      peripheral blood CD4+ and CD8+ levels, CD4+/CD8 ratio, IgE, and NO levels in the 
      observation group were significantly higher than those in the control group (P < 
      0.01). In the observation group, the IL-2 and IL-6 levels, and IgE and NO levels 
      in the MEE were significantly higher than those in peripheral blood (P < 0.01). 
      In addition, in the observation group, the MEE IL-2 and IL-6 levels were 
      positively correlated with peripheral blood CD4+/CD8+ ratio, respectively r = 
      0.366, P = 0.009; r = 0.334, P = 0.018. CONCLUSIONS: The levels of peripheral 
      blood CD4+ and CD8+ lymphocytes and MEE IL-2, IL-6, IgE, and NO levels are 
      increased in children with OME. These indexes have provided significant clues for 
      the diagnosis of OME in children.
FAU - Fan, Wenyan
AU  - Fan W
AUID- ORCID: 0000-0002-7918-3756
AD  - Department of Otolaryngology Head and Neck Surgery, Shanghai Children's Hospital, 
      Shanghai Jiao Tong University, Shanghai 200062, China.
FAU - Li, Xiaoyan
AU  - Li X
AUID- ORCID: 0000-0002-3292-019X
AD  - Department of Otolaryngology Head and Neck Surgery, Shanghai Children's Hospital, 
      Shanghai Jiao Tong University, Shanghai 200062, China.
FAU - Xu, Hongming
AU  - Xu H
AUID- ORCID: 0000-0002-4683-1059
AD  - Department of Otolaryngology Head and Neck Surgery, Shanghai Children's Hospital, 
      Shanghai Jiao Tong University, Shanghai 200062, China.
FAU - Zhao, Limin
AU  - Zhao L
AUID- ORCID: 0000-0001-5623-8817
AD  - Department of Otolaryngology Head and Neck Surgery, Shanghai Children's Hospital, 
      Shanghai Jiao Tong University, Shanghai 200062, China.
FAU - Zhao, Jiali
AU  - Zhao J
AUID- ORCID: 0000-0003-2736-1108
AD  - Department of Otolaryngology Head and Neck Surgery, Shanghai Children's Hospital, 
      Shanghai Jiao Tong University, Shanghai 200062, China.
FAU - Li, Wanpeng
AU  - Li W
AUID- ORCID: 0000-0002-9746-1887
AD  - Department of Otolaryngology Head and Neck Surgery, Shanghai Children's Hospital, 
      Shanghai Jiao Tong University, Shanghai 200062, China.
LA  - eng
PT  - Journal Article
DEP - 20190805
PL  - Brazil
TA  - Rev Assoc Med Bras (1992)
JT  - Revista da Associacao Medica Brasileira (1992)
JID - 9308586
RN  - 0 (Cytokines)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - *CD4-Positive T-Lymphocytes
MH  - *CD8-Positive T-Lymphocytes
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/*blood
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Lymphocyte Count
MH  - Male
MH  - Nitric Oxide/*blood
MH  - Otitis Media with Effusion/*blood
MH  - Reference Values
MH  - Tympanic Membrane/metabolism
EDAT- 2019/08/08 06:00
MHDA- 2019/08/14 06:00
CRDT- 2019/08/08 06:00
PHST- 2019/04/04 00:00 [received]
PHST- 2019/04/19 00:00 [accepted]
PHST- 2019/08/08 06:00 [entrez]
PHST- 2019/08/08 06:00 [pubmed]
PHST- 2019/08/14 06:00 [medline]
AID - S0104-42302019000700971 [pii]
AID - 10.1590/1806-9282.65.7.971 [doi]
PST - epublish
SO  - Rev Assoc Med Bras (1992). 2019 Aug 5;65(7):971-976. doi: 
      10.1590/1806-9282.65.7.971.