PMID- 31389567
OWN - NLM
STAT- MEDLINE
DCOM- 20200904
LR  - 20200904
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 23
IP  - 3 Suppl
DP  - 2019 Aug
TI  - HLA-DPA1 gene polymorphism in primary glaucoma.
PG  - 24-30
LID - 18623 [pii]
LID - 10.26355/eurrev_201908_18623 [doi]
AB  - OBJECTIVE: To explore the association between human leukocyte antigen (HLA)-DPA1 
      gene polymorphism and primary glaucoma. PATIENTS AND METHODS: Six single 
      nucleotide polymorphisms (SNPs) were genotyped in 51 patients and 51 healthy 
      controls through Polymerase Chain Reaction (PCR). The possible association 
      between HLA-DPA1 gene mutation and primary glaucoma was detected using the t-test 
      and the Chi-square test. RESULTS: Rs1676486 genotype had a significant genetic 
      correlation. Rs3753841 and rs12138977 genotypes had a higher minor-allele 
      frequency in control group. The CT + CC genotype frequency of rs12138977 showed a 
      significant genetic correlation in both case group and control group. Moreover, 
      the rs12138977 polymorphism and corneal thickness had little influence on the 
      occurrence of primary angle-closure glaucoma (PACG). Also, the main risk factors 
      for PACG were intraocular hypertension and short axial length. CONCLUSIONS: The 
      HLA-DPA1 gene polymorphism may be related to the severity of PACG.
FAU - Li, J-H
AU  - Li JH
AD  - Department of Laboratory Medicine, Affiliated Hospital of Weifang Medical 
      University, Weifang, China. yiwugongzuo@126.com.
FAU - Shao, J-F
AU  - Shao JF
FAU - Sui, Z-G
AU  - Sui ZG
FAU - Qin, Y-X
AU  - Qin YX
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (HLA-DP alpha-Chains)
RN  - 0 (HLA-DPA1 antigen)
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Glaucoma, Angle-Closure/*genetics
MH  - HLA-DP alpha-Chains/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
EDAT- 2019/08/08 06:00
MHDA- 2020/09/05 06:00
CRDT- 2019/08/08 06:00
PHST- 2019/08/08 06:00 [entrez]
PHST- 2019/08/08 06:00 [pubmed]
PHST- 2020/09/05 06:00 [medline]
AID - 18623 [pii]
AID - 10.26355/eurrev_201908_18623 [doi]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2019 Aug;23(3 Suppl):24-30. doi: 
      10.26355/eurrev_201908_18623.