PMID- 31390138
OWN - NLM
STAT- MEDLINE
DCOM- 20201111
LR  - 20221207
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 12
IP  - 2
DP  - 2020 Feb
TI  - Early life exposure to 1959-1961 Chinese famine exacerbates association between 
      diabetes and cardiovascular disease.
PG  - 134-141
LID - 10.1111/1753-0407.12975 [doi]
AB  - BACKGROUND: We aimed to assess whether early life exposure to the Chinese famine 
      (1959-1961) modifies the association between type 2 diabetes mellitus (T2DM) and 
      cardiovascular disease (CVD) in adulthood. METHODS: Data from 4247 adults born 
      between 1954 and 1964 from the 2011 and 2015 China Health and Retirement 
      Longitudinal Study (CHARLS) were analyzed. CVD in 2011 and 2015 was based on 
      self-reported doctor's diagnosis of cardiac events (heart attack, coronary heart 
      disease, angina, congestive heart failure, or other heart problems) and stroke. 
      Diabetes in 2011 was defined by fasting blood glucose, HbA1C, or known diabetes. 
      RESULTS: Diabetes in 2011 was cross-sectionally associated with an increase of 
      CVD risk in 2011 (OR 1.91, 95%CI 1.53-2.40, P < 0.001) after adjusting for age 
      and gender. Famine exposure changed the association between diabetes and CVD in 
      areas severely affected by famine. The odds ratios (OR) of diabetes in 2011 for 
      CVD in 2015 were 1.24 (95%CI 0.73-2.10), 1.27 (95%CI 0.72-2.24), 2.25 (95%CI 
      1.29-3.91), 4.31 (95%CI 2.07-8.97) and 1.72 (95%CI 0.84-3.51) among adults in 
      late childhood-, mid-childhood-, early childhood-, fetal-, and nonexposed cohorts 
      in severe famine areas, respectively. CONCLUSION: T2DM is associated with the 
      risk of CVD among Chinese adults. Fetal and early childhood exposure to the 
      Chinese famine exacerbated the associated risk.
CI  - (c) 2019 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John 
      Wiley & Sons Australia, Ltd.
FAU - Shi, Zumin
AU  - Shi Z
AUID- ORCID: 0000-0002-3099-3299
AD  - Human Nutrition Department, College of Health Science, QU Health, Qatar 
      University, Doha, Qatar.
FAU - Ji, Linong
AU  - Ji L
AUID- ORCID: 0000-0002-3262-2168
AD  - Peking University Diabetes Center, Director of Department of Endocrinology and 
      Metabolism, Peking University People's Hospital, Beijing, China.
FAU - Ma, Ronald C W
AU  - Ma RCW
AD  - Division of Endocrinology & Diabetes, Department of Medicine & Therapeutics, 
      Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
FAU - Zimmet, Paul
AU  - Zimmet P
AD  - Department of Diabetes, Central Clinical School, Monash University, Melbourne, 
      Australia.
LA  - eng
PT  - Journal Article
DEP - 20190828
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
SB  - IM
MH  - Adverse Childhood Experiences
MH  - Asian People
MH  - Cardiovascular Diseases/complications/*epidemiology
MH  - China/epidemiology
MH  - Diabetes Mellitus, Type 2/complications/*epidemiology
MH  - *Famine
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - 2型糖尿病。
OT  - Chinese
OT  - adults
OT  - cardiovascular disease
OT  - famine
OT  - type 2 diabetes
OT  - 中国人
OT  - 心血管疾病
OT  - 成人
OT  - 饥荒
EDAT- 2019/08/08 06:00
MHDA- 2020/11/12 06:00
CRDT- 2019/08/08 06:00
PHST- 2019/05/21 00:00 [received]
PHST- 2019/07/15 00:00 [revised]
PHST- 2019/08/02 00:00 [accepted]
PHST- 2019/08/08 06:00 [pubmed]
PHST- 2020/11/12 06:00 [medline]
PHST- 2019/08/08 06:00 [entrez]
AID - 10.1111/1753-0407.12975 [doi]
PST - ppublish
SO  - J Diabetes. 2020 Feb;12(2):134-141. doi: 10.1111/1753-0407.12975. Epub 2019 Aug 
      28.