PMID- 31390917
OWN - NLM
STAT- MEDLINE
DCOM- 20200527
LR  - 20200527
IS  - 1750-7448 (Electronic)
IS  - 1750-743X (Linking)
VI  - 11
IP  - 13
DP  - 2019 Sep
TI  - RNA-loaded dendritic cells: more than a tour de force in cancer therapeutics.
PG  - 1129-1147
LID - 10.2217/imt-2019-0058 [doi]
AB  - A wide array of therapeutic strategies has been implemented against cancers, yet 
      their clinical benefit is limited. The lack of clinical efficacy of the 
      conventional treatment options might be due to the inept immune competency of the 
      patients. Dendritic cells (DCs) have a vital role in initiating and directing 
      immune responses and have been frequently used as delivery vehicles in clinical 
      research. The recent clinical data suggest the potential use of DCs pulsed with 
      nucleic acid, especially with RNA holds a great potential as an immunotherapeutic 
      measure with compare to other cancer therapeutics. This review mainly deals with 
      the DCs and their role in transfection with RNA in cancer immunotherapy.
FAU - Joshi, Aishwarya
AU  - Joshi A
AD  - Institute of Science, Nirma University, SG Highway, Ahmedabad 382481, Gujarat, 
      India.
FAU - Tandel, Nikunj
AU  - Tandel N
AD  - Institute of Science, Nirma University, SG Highway, Ahmedabad 382481, Gujarat, 
      India.
FAU - Tyagi, Priyanka
AU  - Tyagi P
AD  - Department of Biological Sciences, School of Basic and Applied Sciences, GD 
      Goenka University, Gurugram 122103, India.
FAU - Dalai, Sarat K
AU  - Dalai SK
AD  - Institute of Science, Nirma University, SG Highway, Ahmedabad 382481, Gujarat, 
      India.
FAU - Bisen, Prakash S
AU  - Bisen PS
AD  - School of Studies in Biotechnology, Jiwaji University, Gwalior 474001, India.
FAU - Tyagi, Rajeev K
AU  - Tyagi RK
AD  - Department of Medicine, Division of Gastroenterology, Hepatology & Nutrition, 
      Vanderbilt University Medical Center (VUMC), Nashville, TN 37232, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190808
PL  - England
TA  - Immunotherapy
JT  - Immunotherapy
JID - 101485158
RN  - 0 (Cancer Vaccines)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/genetics
MH  - Cancer Vaccines/*immunology
MH  - Dendritic Cells/*physiology/transplantation
MH  - Humans
MH  - Immune Tolerance
MH  - Immunity
MH  - Immunotherapy/*methods
MH  - Neoplasms/immunology/*therapy
MH  - RNA/*genetics
MH  - Transfection
MH  - Tumor Microenvironment
OTO - NOTNLM
OT  - antigen-presenting cells (APCs)
OT  - cancer
OT  - dendritic cells (DCs)
OT  - immunotherapy
OT  - transfection
OT  - vaccine
EDAT- 2019/08/09 06:00
MHDA- 2020/05/28 06:00
CRDT- 2019/08/09 06:00
PHST- 2019/08/09 06:00 [pubmed]
PHST- 2020/05/28 06:00 [medline]
PHST- 2019/08/09 06:00 [entrez]
AID - 10.2217/imt-2019-0058 [doi]
PST - ppublish
SO  - Immunotherapy. 2019 Sep;11(13):1129-1147. doi: 10.2217/imt-2019-0058. Epub 2019 
      Aug 8.