PMID- 31391036 OWN - NLM STAT- MEDLINE DCOM- 20200504 LR - 20240117 IS - 1532-429X (Electronic) IS - 1097-6647 (Print) IS - 1097-6647 (Linking) VI - 21 IP - 1 DP - 2019 Aug 8 TI - Echocardiography and cardiovascular magnetic resonance based evaluation of myocardial strain and relationship with late gadolinium enhancement. PG - 46 LID - 10.1186/s12968-019-0559-y [doi] LID - 46 AB - OBJECTIVES: We sought to: (1) determine the agreement in cardiovascular magnetic resonance (CMR) and speckle tracking echocardiography (STE) derived strain measurements, (2) compare their reproducibility, (3) determine which approach is best related to CMR late gadolinium enhancement (LGE). BACKGROUND: While STE-derived strain is routinely used to assess left ventricular (LV) function, CMR strain measurements are not yet standardized. Strain can be measured using dedicated pulse sequences (strain-encoding, SENC), or post-processing of cine images (feature tracking, FT). It is unclear whether these measurements are interchangeable, and whether strain can be used as an alternative to LGE. METHODS: Fifty patients underwent 2D echocardiography and 1.5 T CMR. Global longitudinal strain (GLS) was measured by STE (Epsilon), FT (NeoSoft) and SENC (Myocardial Solutions) and circumferential strain (GCS) by FT and SENC. RESULTS: GLS showed good inter-modality agreement (r-values: 0.71-0.75), small biases (< 1%) but considerable limits of agreement (- 7 to 8%). The agreement between the CMR techniques was better for GLS than GCS (r = 0.81 vs 0.67; smaller bias). Repeated measurements showed low intra- and inter-observer variability for both GLS and GCS (intraclass correlations 0.86-0.99; coefficients of variation 3-13%). LGE was present in 22 (44%) of patients. Both SENC- and FT-derived GLS and GCS were associated with LGE, while STE-GLS was not. Irrespective of CMR technique, this association was stronger for GCS (AUC 0.77-0.78) than GLS (AUC 0.67-0.72) and STE-GLS (AUC = 0.58). CONCLUSION: There is good inter-technique agreement in strain measurements, which were highly reproducible, irrespective of modality or analysis technique. GCS may better reflect the presence of underlying LGE than GLS. FAU - Erley, Jennifer AU - Erley J AD - Department of Internal Medicine / Cardiology, German Heart Center, Berlin, Germany. FAU - Genovese, Davide AU - Genovese D AD - Department of Medicine, University of Chicago Medical Center, 5758 S. Maryland Avenue, MC9067, Chicago, IL, 60637, USA. AD - Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy. FAU - Tapaskar, Natalie AU - Tapaskar N AD - Department of Medicine, University of Chicago Medical Center, 5758 S. Maryland Avenue, MC9067, Chicago, IL, 60637, USA. FAU - Alvi, Nazia AU - Alvi N AD - Department of Medicine, University of Chicago Medical Center, 5758 S. Maryland Avenue, MC9067, Chicago, IL, 60637, USA. AD - Department of Cardiology, Riverside Medical Center, Kankakee, IL, USA. FAU - Rashedi, Nina AU - Rashedi N AD - Department of Medicine, University of Chicago Medical Center, 5758 S. Maryland Avenue, MC9067, Chicago, IL, 60637, USA. FAU - Besser, Stephanie A AU - Besser SA AD - Department of Medicine, University of Chicago Medical Center, 5758 S. Maryland Avenue, MC9067, Chicago, IL, 60637, USA. FAU - Kawaji, Keigo AU - Kawaji K AD - Department of Medicine, University of Chicago Medical Center, 5758 S. Maryland Avenue, MC9067, Chicago, IL, 60637, USA. AD - Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA. FAU - Goyal, Neha AU - Goyal N AD - Department of Medicine, University of Chicago Medical Center, 5758 S. Maryland Avenue, MC9067, Chicago, IL, 60637, USA. FAU - Kelle, Sebastian AU - Kelle S AD - Department of Internal Medicine / Cardiology, German Heart Center, Berlin, Germany. AD - Department of Internal Medicine/Cardiology, Charite Campus Virchow Klinikum, Berlin, Germany. AD - DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Berlin, Germany. FAU - Lang, Roberto M AU - Lang RM AD - Department of Medicine, University of Chicago Medical Center, 5758 S. Maryland Avenue, MC9067, Chicago, IL, 60637, USA. FAU - Mor-Avi, Victor AU - Mor-Avi V AD - Department of Medicine, University of Chicago Medical Center, 5758 S. Maryland Avenue, MC9067, Chicago, IL, 60637, USA. FAU - Patel, Amit R AU - Patel AR AD - Department of Medicine, University of Chicago Medical Center, 5758 S. Maryland Avenue, MC9067, Chicago, IL, 60637, USA. apatel2@medicine.bsd.uchicago.edu. LA - eng PT - Comparative Study PT - Journal Article DEP - 20190808 PL - England TA - J Cardiovasc Magn Reson JT - Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance JID - 9815616 SB - IM MH - Adult MH - *Echocardiography MH - Female MH - Heart Ventricles/*diagnostic imaging/physiopathology MH - Humans MH - *Magnetic Resonance Imaging, Cine MH - Male MH - Middle Aged MH - Multimodal Imaging MH - *Myocardial Contraction MH - Myocardial Ischemia/*diagnostic imaging/physiopathology MH - Observer Variation MH - Predictive Value of Tests MH - Reproducibility of Results MH - Retrospective Studies MH - Stroke Volume MH - Ventricular Dysfunction, Left/*diagnostic imaging/physiopathology MH - *Ventricular Function, Left PMC - PMC6686365 OTO - NOTNLM OT - Cardiac imaging OT - Left ventricular function OT - Myocardial deformation OT - Myocardial scar COIS- The authors declare that they have no competing interests. EDAT- 2019/08/09 06:00 MHDA- 2020/05/06 06:00 PMCR- 2019/08/08 CRDT- 2019/08/09 06:00 PHST- 2019/01/04 00:00 [received] PHST- 2019/07/01 00:00 [accepted] PHST- 2019/08/09 06:00 [entrez] PHST- 2019/08/09 06:00 [pubmed] PHST- 2020/05/06 06:00 [medline] PHST- 2019/08/08 00:00 [pmc-release] AID - S1097-6647(23)00219-3 [pii] AID - 559 [pii] AID - 10.1186/s12968-019-0559-y [doi] PST - epublish SO - J Cardiovasc Magn Reson. 2019 Aug 8;21(1):46. doi: 10.1186/s12968-019-0559-y.