PMID- 31391124 OWN - NLM STAT- MEDLINE DCOM- 20200210 LR - 20200309 IS - 2042-6410 (Electronic) IS - 2042-6410 (Linking) VI - 10 IP - 1 DP - 2019 Aug 7 TI - Sex differences in perceptual responses to experimental pain before and after an experimental fatiguing arm task. PG - 39 LID - 10.1186/s13293-019-0253-7 [doi] LID - 39 AB - BACKGROUND: The incidence and prevalence of musculoskeletal disorders (MSDs) is about twice as high in women compared to men, and those of the neck/shoulder region are particularly high among women. Fatigue and responses towards pain are known risk factor for MSDs. However, women have been shown to be less fatigable than men, but more sensitive to experimental pain. From a general standpoint, sex differences in the relationships between the fatigue and pain pathways are poorly understood. This may be due to differences in how men and women conceptually define the sensations of fatigue and pain. The objective of this study was to compare physical and verbal descriptors of fatigue and pain between men and women undergoing an experimental protocol where fatigue and pain were manipulated. METHODS: Healthy adult volunteers (14 men and 14 women) underwent experimental pain tests to identify pressure pain threshold (PPT) at biceps brachii (BIC), anterior deltoid (AD), and upper trapezius (UT) followed by the Short-form McGill Pain Questionnaire (SF-MPQ) and Pain Catastrophizing Scale (PCS) before and after a repetitive arm task performed at shoulder height until reaching a rating of neck/shoulder perceived exertion, using the Borg Category Ratio 10 (CR10), greater than 8/10. PPT and MPQ data were analyzed using repeated measures analyses of variance (ANOVA) (time x sex). Correlational analyses were used to investigate relationships between pain measures with time and fatigue. RESULTS: UT PPT was reduced following the fatiguing task (p