PMID- 31392078
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2156-6976 (Print)
IS  - 2156-6976 (Electronic)
IS  - 2156-6976 (Linking)
VI  - 9
IP  - 7
DP  - 2019
TI  - Natriuretic peptide receptor a promotes breast cancer development by upregulating 
      MMP9.
PG  - 1415-1428
AB  - Natriuretic peptide receptor A (NPRA), one of the natriuretic peptide receptors, 
      plays important roles in circulatory system. Recently some studies showed that 
      NPRA was involved in tumorigenesis, however, its role in the development of 
      breast cancer remains unclear. In this study, we observed that NPRA expression 
      was upregulated in breast cancer tissues and NPRA high expression was associated 
      with poor clinicopathological features. In addition, we found that patients with 
      high NPRA expression had a worse 5-year survival and NPRA was an independent 
      factor for predicting the prognosis of breast cancer patients. Knocking down NPRA 
      expression reduced the proliferation, migration and invasion of breast cancer 
      cells. Overexpressing NPRA was able to enhance the malignant behaviors of breast 
      cancer cells. Furthermore, NPRA promoted the invasive phenotype through 
      upregulating matrix metalloproteinase-9 (MMP9). Mechanistically, NPRA increased 
      MMP9 expression through activating STAT3. We identified that NPRA might serve as 
      a prognostic marker and p-STAT3 and MMP9 could be a potential target of NPRA in 
      breast cancer patients.
FAU - Qu, Jingkun
AU  - Qu J
AD  - The Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an 
      Jiaotong University 277 West Yanta Road, Xi'an 710061, Shaanxi, P. R. China.
FAU - Zhao, Xixi
AU  - Zhao X
AD  - Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong 
      University 157 West Fifth Street, Xi'an 710004, Shaanxi, P. R. China.
FAU - Liu, Xu
AU  - Liu X
AD  - The Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an 
      Jiaotong University 277 West Yanta Road, Xi'an 710061, Shaanxi, P. R. China.
FAU - Sun, Yuchen
AU  - Sun Y
AD  - The Department of Radiation Oncology, The First Affiliated Hospital of Xi'an 
      Jiaotong University 277 West Yanta Road, Xi'an 710061, Shaanxi, P. R. China.
FAU - Wang, Jizhao
AU  - Wang J
AD  - The Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an 
      Jiaotong University 277 West Yanta Road, Xi'an 710061, Shaanxi, P. R. China.
FAU - Liu, Lin
AU  - Liu L
AD  - The Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an 
      Jiaotong University 277 West Yanta Road, Xi'an 710061, Shaanxi, P. R. China.
FAU - Wang, Jiansheng
AU  - Wang J
AD  - The Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an 
      Jiaotong University 277 West Yanta Road, Xi'an 710061, Shaanxi, P. R. China.
FAU - Zhang, Jia
AU  - Zhang J
AD  - The Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an 
      Jiaotong University 277 West Yanta Road, Xi'an 710061, Shaanxi, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20190701
PL  - United States
TA  - Am J Cancer Res
JT  - American journal of cancer research
JID - 101549944
PMC - PMC6682717
OTO - NOTNLM
OT  - MMP9
OT  - NPRA
OT  - STAT3
OT  - breast cancer
OT  - prognosis
COIS- None.
EDAT- 2019/08/09 06:00
MHDA- 2019/08/09 06:01
PMCR- 2019/07/01
CRDT- 2019/08/09 06:00
PHST- 2019/05/24 00:00 [received]
PHST- 2019/06/14 00:00 [accepted]
PHST- 2019/08/09 06:00 [entrez]
PHST- 2019/08/09 06:00 [pubmed]
PHST- 2019/08/09 06:01 [medline]
PHST- 2019/07/01 00:00 [pmc-release]
PST - epublish
SO  - Am J Cancer Res. 2019 Jul 1;9(7):1415-1428. eCollection 2019.