PMID- 31392534
OWN - NLM
STAT- MEDLINE
DCOM- 20210705
LR  - 20220209
IS  - 1573-7322 (Electronic)
IS  - 1382-4147 (Linking)
VI  - 25
IP  - 5
DP  - 2020 Sep
TI  - Association of QRS narrowing with response to cardiac resynchronization therapy-a 
      systematic review and meta-analysis of observational studies.
PG  - 745-756
LID - 10.1007/s10741-019-09839-5 [doi]
AB  - Prolonged QRS duration, which reflects a higher degree of mechanical dysynchrony, 
      is a predictor of response to CRT. However, the association of QRS narrowing 
      after biventricular pacing with CRT response rates is not clear. Our aim was to 
      conduct a systematic review and meta-analysis on the association between QRS 
      narrowing after cardiac resynchronization therapy (CRT) and clinical and 
      echocardiographic response to CRT in patients with heart failure. Two independent 
      investigators searched MedLine and EMBASE databases through July 2018 without any 
      limitations. Studies providing estimates (continuous data) on the association of 
      QRS shortening with either clinical (defined as New York Heart Association (NYHA) 
      reduction >/= 1) or echocardiographic (defined as left ventricular end-systolic 
      volume (LVESV) reduction >/= 15%) response to CRT were finally included in the 
      quantitative synthesis. We included 32 studies (14 studies (1274 patients mean 
      age 64 years old, males 79.3%) using clinical CRT response and 18 studies (1270 
      patients, mean age 64 years old, males 69.1%) using echocardiographic CRT 
      response). A significant association between QRS narrowing and shorter attained 
      QRS duration with clinical and echocardiographic CRT response was observed. The 
      observed association was independent of the timing of QRS width measurement after 
      CRT implantation. Acute and late improvement of electrical dysynchrony as 
      depicted by QRS narrowing following biventricular pacing is associated with 
      clinical and echocardiographic response to CRT. However, large prospective 
      studies are needed to further examine our findings.
FAU - Bazoukis, George
AU  - Bazoukis G
AUID- ORCID: 0000-0003-1009-9772
AD  - Second Department of Cardiology, Evangelismos General Hospital of Athens, Athens, 
      Greece. gbazoykis@med.uoa.gr.
AD  - The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. 
      gbazoykis@med.uoa.gr.
FAU - Naka, Katerina K
AU  - Naka KK
AD  - Second Department of Cardiology, University of Ioannina, GR 45110, Ioannina, 
      Greece.
FAU - Alsheikh-Ali, Alawi
AU  - Alsheikh-Ali A
AD  - College of Medicine, Mohammed Bin Rashid University of Medicine and Health 
      Sciences, Dubai, United Arab Emirates.
FAU - Tse, Gary
AU  - Tse G
AD  - Department of Medicine and Therapeutics, Faculty of Medicine, Chinese University 
      of Hong Kong, Hong Kong, SAR, People's Republic of China.
AD  - Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Chinese University 
      of Hong Kong, Hong Kong, SAR, People's Republic of China.
FAU - Letsas, Konstantinos P
AU  - Letsas KP
AD  - Second Department of Cardiology, Evangelismos General Hospital of Athens, Athens, 
      Greece.
FAU - Korantzopoulos, Panagiotis
AU  - Korantzopoulos P
AD  - First Department of Cardiology, University of Ioannina, GR 45110, Ioannina, 
      Greece.
FAU - Liu, Tong
AU  - Liu T
AD  - Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of 
      Tianjin Medical University, Tianjin, People's Republic of China.
FAU - Yeung, Cynthia
AU  - Yeung C
AD  - Division of Cardiology, Queen's University, Kingston, Ontario, Canada.
FAU - Efremidis, Michael
AU  - Efremidis M
AD  - Second Department of Cardiology, Evangelismos General Hospital of Athens, Athens, 
      Greece.
FAU - Tsioufis, Konstantinos
AU  - Tsioufis K
AD  - First Cardiology Clinic, Medical School, Hippokration Hospital, National and 
      Kapodistrian University of Athens, Athens, Greece.
FAU - Baranchuk, Adrian
AU  - Baranchuk A
AD  - Division of Cardiology, Queen's University, Kingston, Ontario, Canada.
FAU - Stavrakis, Stavros
AU  - Stavrakis S
AD  - The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
PL  - United States
TA  - Heart Fail Rev
JT  - Heart failure reviews
JID - 9612481
SB  - IM
MH  - Cardiac Resynchronization Therapy/*methods
MH  - *Electrocardiography
MH  - Heart Failure/physiopathology/*therapy
MH  - Humans
MH  - Observational Studies as Topic
OTO - NOTNLM
OT  - CRT response
OT  - Cardiac resynchronization therapy
OT  - Electrical dysynchrony
OT  - QRS narrowing
EDAT- 2019/08/09 06:00
MHDA- 2021/07/06 06:00
CRDT- 2019/08/09 06:00
PHST- 2019/08/09 06:00 [pubmed]
PHST- 2021/07/06 06:00 [medline]
PHST- 2019/08/09 06:00 [entrez]
AID - 10.1007/s10741-019-09839-5 [pii]
AID - 10.1007/s10741-019-09839-5 [doi]
PST - ppublish
SO  - Heart Fail Rev. 2020 Sep;25(5):745-756. doi: 10.1007/s10741-019-09839-5.