PMID- 31393374
OWN - NLM
STAT- MEDLINE
DCOM- 20190820
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 98
IP  - 32
DP  - 2019 Aug
TI  - Analysis of human leukocyte antigen allele polymorphism in patients with non 
      alcoholic fatty liver disease.
PG  - e16704
LID - 10.1097/MD.0000000000016704 [doi]
LID - e16704
AB  - The human leukocyte antigen (HLA) genes may play a role in the pathogenesis of 
      non-alcoholic fatty liver disease (NAFLD) and its progressive form, non-alcoholic 
      steatohepatitis (NASH). The aim of this study was to assess the association of 
      HLA class I and II alleles with NASH and its histological 
      features.Deoxyribonucleic acid (DNA) was extracted from 140 subjects (85 
      biopsy-proven NAFLD and 55 controls) and genotyped for HLA (-A, -B, -C, -DR1, 
      -DR3, -DQ, and -DP). Liver biopsies were assessed for presence of NASH, degree of 
      fibrosis and inflammation. Multivariate analysis was performed to assess 
      associations between HLA genes and different histologic features of NAFLD.Our 
      data for HLA class I showed that HLA-C*4 was associated with lower risk for 
      histologic NASH and HLA-C*6 was protective against portal fibrosis. Conversely, 
      HLA-B*27 was associated with high-grade hepatic steatosis, while HLA-A*31 was 
      associated with increased risk for advanced fibrosis. Among HLA class II alleles, 
      HLA-DQA1*01 was associated with lower risk for NASH while HLA-DRB1*03 was 
      associated with increased risk for NASH.Our findings indicate that HLA class I 
      and II gene polymorphism may be associated with susceptibility to NASH, fibrosis 
      and other pathologic features and may be involved in the pathogenesis of NAFLD.
FAU - Karrar, Azza
AU  - Karrar A
AD  - Betty and Guy Beatty Center for Integrated Research, Inova Health System.
FAU - Hariharan, Siddharth
AU  - Hariharan S
AD  - Betty and Guy Beatty Center for Integrated Research, Inova Health System.
FAU - Fazel, Yousef
AU  - Fazel Y
AD  - Betty and Guy Beatty Center for Integrated Research, Inova Health System.
FAU - Moosvi, Ali
AU  - Moosvi A
AD  - Betty and Guy Beatty Center for Integrated Research, Inova Health System.
FAU - Houry, Mohamad
AU  - Houry M
AD  - Betty and Guy Beatty Center for Integrated Research, Inova Health System.
FAU - Younoszai, Zahra
AU  - Younoszai Z
AD  - Betty and Guy Beatty Center for Integrated Research, Inova Health System.
FAU - Jeffers, Thomas
AU  - Jeffers T
AD  - Betty and Guy Beatty Center for Integrated Research, Inova Health System.
FAU - Zheng, Li
AU  - Zheng L
AD  - Betty and Guy Beatty Center for Integrated Research, Inova Health System.
FAU - Munkhzul, Otgonsuren
AU  - Munkhzul O
AD  - Betty and Guy Beatty Center for Integrated Research, Inova Health System.
FAU - Hunt, Sharon
AU  - Hunt S
AD  - Betty and Guy Beatty Center for Integrated Research, Inova Health System.
FAU - Monge, Fanny
AU  - Monge F
AD  - Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls 
      Church, VA.
FAU - Goodman, Zachary
AU  - Goodman Z
AD  - Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls 
      Church, VA.
FAU - Younossi, Zobair M
AU  - Younossi ZM
AD  - Betty and Guy Beatty Center for Integrated Research, Inova Health System.
AD  - Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls 
      Church, VA.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Female
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease/*genetics/immunology/pathology
MH  - Polymorphism, Genetic
MH  - Prospective Studies
PMC - PMC6708789
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2019/08/09 06:00
MHDA- 2019/08/21 06:00
PMCR- 2019/08/09
CRDT- 2019/08/09 06:00
PHST- 2019/08/09 06:00 [entrez]
PHST- 2019/08/09 06:00 [pubmed]
PHST- 2019/08/21 06:00 [medline]
PHST- 2019/08/09 00:00 [pmc-release]
AID - 00005792-201908090-00034 [pii]
AID - MD-D-19-01802 [pii]
AID - 10.1097/MD.0000000000016704 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2019 Aug;98(32):e16704. doi: 10.1097/MD.0000000000016704.