PMID- 31393692
OWN - NLM
STAT- MEDLINE
DCOM- 20200129
LR  - 20200129
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 11
IP  - 35
DP  - 2019 Sep 4
TI  - Regulating Fluorescent Aptamer-Sensing Behavior of Zeolitic Imidazolate Framework 
      (ZIF-8) Platform via Lanthanide Ion Doping.
PG  - 31755-31762
LID - 10.1021/acsami.9b12253 [doi]
AB  - Nanoscale metal-organic frameworks (NMOFs) have been proved to be effective 
      quenching platforms for fluorescent detection of DNA via fluorophore-quencher 
      pairs. Zeolitic imidazolate framework-8 (ZIF-8) is one type of the most promising 
      NMOFs because of its excellent biocompatibility and easy preparation. However, 
      ZIF-8 is rarely used as platforms for fluorescence sensing of DNA because of its 
      bad fluorescence quenching property. In this study, lanthanide ions were doped 
      into ZIF-8 to regulate its fluorescence quenching behavior. The La(3+) doped 
      ZIF-8 (ZIF-8-La) showed the best quenching efficiency on dye-labeled DNA. The 
      signal-to-background ratio was around 3 times higher than ZIF-8. Furthermore, a 
      core-shell La(3+)-doped ZIF-8 (CS-ZIF-8-La) was designed to modify more La(3+) on 
      the surface of ZIF-8. Compared with ZIF-8-La, the CS-ZIF-8-La exhibited the same 
      fluorescence sensing behavior toward positive-dye-labeled DNA, but showed 
      completely contrary quenching property on the negative-dye-labeled DNA. On the 
      basis of this phenomenon, CS-ZIF-8-La was successfully used as quenching platform 
      for designing a ratiometric sensor for DNA and microRNA.
FAU - Hao, Ya-Bo
AU  - Hao YB
AD  - Department of Pharmaceutical Analysis , China Pharmaceutical University , Nanjing 
      210009 , China.
AD  - Tianjin Key Laboratory of Food Biotechnology , Tianjin University of Commerce , 
      Tianjin 300134 , China.
FAU - Shao, Zhen-Shu
AU  - Shao ZS
AD  - Department of Pharmaceutical Analysis , China Pharmaceutical University , Nanjing 
      210009 , China.
FAU - Cheng, Chen
AU  - Cheng C
AD  - Department of Pharmaceutical Analysis , China Pharmaceutical University , Nanjing 
      210009 , China.
FAU - Xie, Xiao-Yu
AU  - Xie XY
AUID- ORCID: 0000-0003-3936-3565
AD  - School of Pharmacy, Health Science Center , Xi'an Jiaotong University , Xi'an 
      710061 , China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Tianjin Key Laboratory of Food Biotechnology , Tianjin University of Commerce , 
      Tianjin 300134 , China.
FAU - Song, Wen-Jun
AU  - Song WJ
AD  - Tianjin Key Laboratory of Food Biotechnology , Tianjin University of Commerce , 
      Tianjin 300134 , China.
FAU - Wang, Huai-Song
AU  - Wang HS
AUID- ORCID: 0000-0001-7892-018X
AD  - Department of Pharmaceutical Analysis , China Pharmaceutical University , Nanjing 
      210009 , China.
LA  - eng
PT  - Journal Article
DEP - 20190820
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Aptamers, Nucleotide)
RN  - 0 (Metal-Organic Frameworks)
RN  - 0 (MicroRNAs)
RN  - 1318-02-1 (Zeolites)
RN  - 6I3K30563S (Lanthanum)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Aptamers, Nucleotide/*chemistry
MH  - DNA/*analysis
MH  - Fluorescence
MH  - HeLa Cells
MH  - Humans
MH  - Lanthanum/*chemistry
MH  - Metal-Organic Frameworks/*chemistry
MH  - MicroRNAs/*analysis
MH  - Zeolites/*chemistry
OTO - NOTNLM
OT  - DNA/microRNA;
OT  - fluorescence quenching
OT  - lanthanide ions;
OT  - metal-organic frameworks;
OT  - ratiometric sensing;
EDAT- 2019/08/09 06:00
MHDA- 2020/01/30 06:00
CRDT- 2019/08/09 06:00
PHST- 2019/08/09 06:00 [pubmed]
PHST- 2020/01/30 06:00 [medline]
PHST- 2019/08/09 06:00 [entrez]
AID - 10.1021/acsami.9b12253 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2019 Sep 4;11(35):31755-31762. doi: 
      10.1021/acsami.9b12253. Epub 2019 Aug 20.