PMID- 31393987
OWN - NLM
STAT- MEDLINE
DCOM- 20200117
LR  - 20200117
IS  - 1938-2391 (Electronic)
IS  - 1081-597X (Linking)
VI  - 35
IP  - 8
DP  - 2019 Aug 1
TI  - Long-Term Effect of Anterior Chamber Depth on Endothelial Cell Density in 
      Patients With Iris-Fixated Phakic Intraocular Lenses.
PG  - 493-500
LID - 10.3928/1081597X-20190708-01 [doi]
AB  - PURPOSE: To evaluate the long-term endothelial cell density (ECD) change and its 
      correlation with preoperative anterior chamber depth (ACD) and aqueous depth 
      (AQD) in patients with iris-fixated phakic intraocular lenses (pIOLs). METHODS: A 
      total of 90 eyes from 57 patients who underwent pIOL implantation were 
      retrospectively enrolled. Correlation between ACD and endothelial cell loss (ECL) 
      was investigated. Optimal cut-off values for ACD and AQD were assessed. RESULTS: 
      The average follow-up period was 11.8 +/- 2.0 years (range: 9.1 to 17.3 years). 
      Compared to the baseline data, the mean ECD change was -894 +/- 732 cells/mm(2) 
      (range: -2,281 to 389 cells/mm(2)). The mean ECD change from baseline was -53.5% 
      +/- 19.1% (range: -75.1% to -5.2%) in eyes with preoperative ACD of 3.20 mm or 
      greater -26.0% +/- 26.6% (range: -74.1% to 0.9%) in eyes with ACD of 3.21 to 3.49 
      mm, and -5.2 +/- 8.7% (range: -21.3% to 16.8%) in eyes with ACD of 3.50 mm or 
      greater (P < .001). No eyes with ACD of 3.50 mm or greater had significant 
      endothelial cell loss (SECL), whereas 84% of the eyes with ACD of 3.20 mm or less 
      experienced SECL (P < .001). There was a significant negative correlation between 
      ECL and ACD (r = -0.70, P < .001) and AQD (r = -0.65, P < .001). Receiver 
      operating characteristic curve analysis revealed that ACD of 3.35 mm provides 84% 
      sensitivity and 88% specificity and AQD of 2.75 mm provides 88% sensitivity and 
      81% specificity for preventing SECL. CONCLUSIONS: Smaller ACD and AQD are 
      significantly correlated with more ECL. Minimum ACD of 3.35 mm or AQD of 2.75 mm 
      are recommended for better long-term endothelial safety. [J Refract Surg. 
      2019;35(8):493-500.].
CI  - Copyright 2019, SLACK Incorporated.
FAU - Eldanasoury, Alaa M
AU  - Eldanasoury AM
FAU - Roozbahani, Mehdi
AU  - Roozbahani M
FAU - Tolees, Sherif
AU  - Tolees S
FAU - Arana, Christina
AU  - Arana C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Refract Surg
JT  - Journal of refractive surgery (Thorofare, N.J. : 1995)
JID - 9505927
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anterior Chamber/*pathology
MH  - Astigmatism/*surgery
MH  - Cell Count
MH  - Endothelium, Corneal/*pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Iris/*surgery
MH  - Lens Implantation, Intraocular/*methods
MH  - Male
MH  - Middle Aged
MH  - Myopia/*surgery
MH  - *Phakic Intraocular Lenses
MH  - Pseudophakia/physiopathology
MH  - ROC Curve
MH  - Refraction, Ocular/physiology
MH  - Retrospective Studies
MH  - Visual Acuity/physiology
MH  - Young Adult
EDAT- 2019/08/09 06:00
MHDA- 2020/01/18 06:00
CRDT- 2019/08/09 06:00
PHST- 2019/04/19 00:00 [received]
PHST- 2019/07/08 00:00 [accepted]
PHST- 2019/08/09 06:00 [entrez]
PHST- 2019/08/09 06:00 [pubmed]
PHST- 2020/01/18 06:00 [medline]
AID - 10.3928/1081597X-20190708-01 [doi]
PST - ppublish
SO  - J Refract Surg. 2019 Aug 1;35(8):493-500. doi: 10.3928/1081597X-20190708-01.