PMID- 31394144
OWN - NLM
STAT- MEDLINE
DCOM- 20200831
LR  - 20200831
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 375
DP  - 2019 Dec 16
TI  - Distinct dynamic functional connectivity patterns of pain and touch thresholds: A 
      resting-state fMRI study.
PG  - 112142
LID - S0166-4328(19)30711-9 [pii]
LID - 10.1016/j.bbr.2019.112142 [doi]
AB  - Dynamic functional connectivity (dFC) analysis based on resting-state functional 
      magnetic resonance imaging (fMRI) has gained popularity in recent years. Despite 
      many studies have linked dFC patterns to various mental diseases and cognitive 
      functions, little research has used dFC in the investigation of low-level sensory 
      perception. The present study is aimed to explore resting-state fMRI dFC patterns 
      correlated with thresholds of two types of perception, pain and touch, on an 
      individual basis. We collected and analyzed resting-state fMRI data and 
      thresholds of pain and touch from 80 healthy participants. dFC states were 
      identified by using independent component analysis, sliding window correlation, 
      and clustering, and then the thresholds of pain and touch are correlated with the 
      occurrence frequencies of dFC states. A new permutation analysis is developed to 
      make identified dFC states more interpretable. We found that the occurrence 
      frequency of a default mode network (DMN)-dominated state was positively 
      correlated with the pain threshold, while the occurrence frequency of a static 
      functional connectivity (sFC)-like state was negatively correlated with the touch 
      threshold. This study showed that the thresholds of pain and touch have distinct 
      dFC correlates, suggesting different influences of baseline brain states on 
      different types of sensory perception. This study also showed that dFC could 
      serve as an indicator of an individual's pain sensitivity, which can be 
      potentially used for pain management.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Yuan, Yueming
AU  - Yuan Y
AD  - School of Biomedical Engineering, Health Science Center, Shenzhen University, 
      Shenzhen, 518060, China; Guangdong Provincial Key Laboratory of Biomedical 
      Measurements and Ultrasound Imaging, Shenzhen, 518060, China.
FAU - Zhang, Li
AU  - Zhang L
AD  - School of Biomedical Engineering, Health Science Center, Shenzhen University, 
      Shenzhen, 518060, China; Guangdong Provincial Key Laboratory of Biomedical 
      Measurements and Ultrasound Imaging, Shenzhen, 518060, China.
FAU - Li, Linling
AU  - Li L
AD  - School of Biomedical Engineering, Health Science Center, Shenzhen University, 
      Shenzhen, 518060, China; Guangdong Provincial Key Laboratory of Biomedical 
      Measurements and Ultrasound Imaging, Shenzhen, 518060, China.
FAU - Huang, Gan
AU  - Huang G
AD  - School of Biomedical Engineering, Health Science Center, Shenzhen University, 
      Shenzhen, 518060, China; Guangdong Provincial Key Laboratory of Biomedical 
      Measurements and Ultrasound Imaging, Shenzhen, 518060, China.
FAU - Anter, Ahmed
AU  - Anter A
AD  - School of Biomedical Engineering, Health Science Center, Shenzhen University, 
      Shenzhen, 518060, China; Guangdong Provincial Key Laboratory of Biomedical 
      Measurements and Ultrasound Imaging, Shenzhen, 518060, China.
FAU - Liang, Zhen
AU  - Liang Z
AD  - School of Biomedical Engineering, Health Science Center, Shenzhen University, 
      Shenzhen, 518060, China; Guangdong Provincial Key Laboratory of Biomedical 
      Measurements and Ultrasound Imaging, Shenzhen, 518060, China.
FAU - Zhang, Zhiguo
AU  - Zhang Z
AD  - School of Biomedical Engineering, Health Science Center, Shenzhen University, 
      Shenzhen, 518060, China; Guangdong Provincial Key Laboratory of Biomedical 
      Measurements and Ultrasound Imaging, Shenzhen, 518060, China; Peng Cheng 
      Laboratory, Shenzhen, 518055, China. Electronic address: zgzhang@szu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190805
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
SB  - IM
MH  - Adult
MH  - Brain Mapping
MH  - Cluster Analysis
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Nerve Net/diagnostic imaging/physiology
MH  - Neural Pathways/physiology
MH  - Pain Threshold/*physiology
MH  - Sensory Thresholds/*physiology
MH  - Touch/*physiology
MH  - Young Adult
OTO - NOTNLM
OT  - Dynamic functional connectivity
OT  - Functional magnetic resonance imaging
OT  - Pain sensitivity
OT  - Pain threshold
OT  - Touch threshold
EDAT- 2019/08/09 06:00
MHDA- 2020/09/01 06:00
CRDT- 2019/08/09 06:00
PHST- 2019/05/13 00:00 [received]
PHST- 2019/07/07 00:00 [revised]
PHST- 2019/08/02 00:00 [accepted]
PHST- 2019/08/09 06:00 [pubmed]
PHST- 2020/09/01 06:00 [medline]
PHST- 2019/08/09 06:00 [entrez]
AID - S0166-4328(19)30711-9 [pii]
AID - 10.1016/j.bbr.2019.112142 [doi]
PST - ppublish
SO  - Behav Brain Res. 2019 Dec 16;375:112142. doi: 10.1016/j.bbr.2019.112142. Epub 
      2019 Aug 5.