PMID- 31394697
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20190809
IS  - 1790-6245 (Electronic)
IS  - 1109-6535 (Linking)
VI  - 3
IP  - 3-4
DP  - 2006 May-Aug
TI  - Association of HLA-DRB1 and -DQB1 with Classic Kaposi's Sarcoma in Mainland 
      Italy.
PG  - 191-196
AB  - Classic Kaposi's sarcoma (CKS) is a multifocal vascular mesenchymal tumour of 
      unknown origin. Human herpesvirus 8 (HHV8) is now considered to be strongly 
      involved, as a necessary co-factor, though insufficient for development of the 
      disease. Additional identified risk factors include environmental factors, 
      personal habits and genetic susceptibility, with different loci suspected of 
      being risk factors for CKS. Since various human leukocyte antigen (HLA) patterns 
      have been suggested as potential host-related co-factors, the distribution of 
      these alleles was studied in 41 CKS patients, 285 geographically-matched healthy 
      controls (HC) and 17 HHV8-positive controls. Molecular typing of HLA was 
      performed using the polymerase chain reaction sequence-specific primer method 
      (SSP-PCR). Frequency distribution was evaluated by the Chi-squared test with 
      Yates' correction. Odds ratios (OR) and respective 95% confidence limits (CI) 
      were calculated. A significantly higher frequency of HLA-DRB1*13 was observed 
      among the CKS patients (20.7%) compared to the HC (9.8%) (p<0.01; OR: 2.32; 
      95%CI: 1.21-4.41). Overall, these results indicated that HLA-DRB1*13 may play a 
      role in the development of CKS, while HLA-DQB1*0604 allele involvement occurs in 
      linkage disequilibrium with HLA-DRB1*13. To our knowledge, this is the first 
      study documenting an HLA-DRB1 and -DQB1 loci association with CKS development in 
      the mainland Italian population.
CI  - Copyright(c) 2006 International Institute of Anticaner Research (Dr. John G. 
      Delinassios), All rights reserved.
FAU - Guerini, Franca Rosa
AU  - Guerini FR
AD  - Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Fond. IRCCS, 
      S. Maria Nascente, Via Capecelatro 66, 20148 Milan.
FAU - Agliardi, Cristina
AU  - Agliardi C
AD  - Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Fond. IRCCS, 
      S. Maria Nascente, Via Capecelatro 66, 20148 Milan.
FAU - Mancuso, Roberta
AU  - Mancuso R
AD  - Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Fond. IRCCS, 
      S. Maria Nascente, Via Capecelatro 66, 20148 Milan.
FAU - Brambilla, Lucia
AU  - Brambilla L
AD  - Institute of Dermatology Sciences of the University of Milan and IRCCS Ospedale 
      Maggiore, Milan.
FAU - Biffi, Renato
AU  - Biffi R
AD  - Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Fond. IRCCS, 
      S. Maria Nascente, Via Capecelatro 66, 20148 Milan.
FAU - Ferrucci, Silvia
AU  - Ferrucci S
AD  - Institute of Dermatology Sciences of the University of Milan and IRCCS Ospedale 
      Maggiore, Milan.
FAU - Zanetta, Lorenzo
AU  - Zanetta L
AD  - Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Fond. IRCCS, 
      S. Maria Nascente, Via Capecelatro 66, 20148 Milan.
FAU - Zanzottera, Milena
AU  - Zanzottera M
AD  - Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Fond. IRCCS, 
      S. Maria Nascente, Via Capecelatro 66, 20148 Milan.
FAU - Brambati, Marinella
AU  - Brambati M
AD  - Institute of Dermatology Sciences of the University of Milan and IRCCS Ospedale 
      Maggiore, Milan.
FAU - Boneschi, Vinicio
AU  - Boneschi V
AD  - Institute of Dermatology Sciences of the University of Milan and IRCCS Ospedale 
      Maggiore, Milan.
FAU - Ferrante, Pasquale
AU  - Ferrante P
AD  - Chair of Virology, Department of Biomedical Sciences and Technology, University 
      of Milan, Via F.lli Cervi 93, 20090 Segrate, Milan, Italy fguerini@dongnocchi.it.
LA  - eng
PT  - Journal Article
DEP - 20060101
PL  - Greece
TA  - Cancer Genomics Proteomics
JT  - Cancer genomics & proteomics
JID - 101188791
SB  - IM
OTO - NOTNLM
OT  - Classic Kaposi's sarcoma
OT  - human herpesvirus 8
OT  - human leukocyte antigens
EDAT- 2006/05/01 00:00
MHDA- 2006/05/01 00:01
CRDT- 2019/08/10 06:00
PHST- 2006/05/23 00:00 [received]
PHST- 2006/06/05 00:00 [accepted]
PHST- 2019/08/10 06:00 [entrez]
PHST- 2006/05/01 00:00 [pubmed]
PHST- 2006/05/01 00:01 [medline]
AID - 3/3-4/191 [pii]
PST - ppublish
SO  - Cancer Genomics Proteomics. 2006 May-Aug;3(3-4):191-196. Epub 2006 Jan 1.