PMID- 31394712
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20190809
IS  - 1790-6245 (Electronic)
IS  - 1109-6535 (Linking)
VI  - 2
IP  - 4
DP  - 2005 Jul-Aug
TI  - The Cell Cycle Regulators P16(INK4a), P15(INK4b) and Cyclin D1: Relationship to 
      Clinicopathological Parameters and Disease-free Survival in Laryngeal Carcinoma 
      Patients.
PG  - 239-245
AB  - Laryngeal squamous cell carcinoma (LSCC) is a frequent malignancy with a complex 
      and undefined etiology to date. The recently identified cyclin-dependent kinase 
      inhibitor p15(INK4b) is frequently deleted in human tumors. Previous evidence has 
      pointed to a related gene, p16(INK4a), as another target for deletion. Both genes 
      express cyclin D inhibitor proteins. To determine the importance of cell cycle 
      regulators in LSCC relative to more traditional surgical and pathological 
      prognostic factors, p15(INK4b), p16(INK4a) and cyclin D1 analyses were performed. 
      Forty-one malignant tumor tissues and 20 minimal pathological lesions (MPL) of 
      the larynx were examined for deletion of the p16(INK4a) and p15(INK4b) genes 
      using polymerase chain reaction. Cyclin D1 expression was studied by Western 
      blotting. Deletions of p16(INK4a) and p15(INK4b) were observed in 48.8 % and 
      51.2% of LSCC patients, respectively. Meanwhile, no deletion was observed in MPL 
      (p<0.001). Cyclin D1 was expressed in 43.9% of patients with LSCC versus 30% with 
      MPL (p=0.29). Although the frequency of p16(INK4a) and p15(INK4b) deletions were 
      higher in advanced than early tumor stages, the difference was statistically 
      insignificant. Ninety percent of patients with deletion of p16(INK4a) had 
      deletion of the p15(INK4b) gene. Both cyclin D1 expression and deletion of 
      p15(INK4b) were found to be independent prognotic predictors of disease 
      recurrence. p16(INK4a) and p15(INK4b) gene deletions are exclusively related to 
      malignancy of the larynx. Cyclin D1 expression and p15(INK4b) gene deletion are 
      potential prognostic indicators of recurrence of LSCC.
CI  - Copyright(c) 2005 International Institute of Anticaner Research (Dr. John G. 
      Delinassios), All rights reserved.
FAU - El-Salahy, Eman
AU  - El-Salahy E
AD  - Medical Biochemistry, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
FAU - Abou-Ghalia, Azza H
AU  - Abou-Ghalia AH
AD  - Medical Biochemistry, Faculty of Medicine, Ain Shams University, Cairo, Egypt 
      azzaaboghalia@yahoo.com.
FAU - Adli, Ahmed
AU  - Adli A
AD  - Otolaryngology Departments, Faculty of Medicine, Ain Shams University, Cairo, 
      Egypt.
FAU - Kassim, Samar K
AU  - Kassim SK
AD  - Medical Biochemistry, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20050701
PL  - Greece
TA  - Cancer Genomics Proteomics
JT  - Cancer genomics & proteomics
JID - 101188791
SB  - IM
OTO - NOTNLM
OT  - Laryngeal carcinoma
OT  - cyclin D1
OT  - disease-free survival
OT  - p15INK4b
OT  - p16INK4a
EDAT- 2005/07/01 00:00
MHDA- 2005/07/01 00:01
CRDT- 2019/08/10 06:00
PHST- 2005/04/19 00:00 [received]
PHST- 2005/05/06 00:00 [accepted]
PHST- 2019/08/10 06:00 [entrez]
PHST- 2005/07/01 00:00 [pubmed]
PHST- 2005/07/01 00:01 [medline]
AID - 2/4/239 [pii]
PST - ppublish
SO  - Cancer Genomics Proteomics. 2005 Jul-Aug;2(4):239-245. Epub 2005 Jul 1.