PMID- 31394776
OWN - NLM
STAT- MEDLINE
DCOM- 20200511
LR  - 20231213
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 8
IP  - 8
DP  - 2019 Aug 7
TI  - HLA-E Polymorphism Determines Susceptibility to BK Virus Nephropathy after 
      Living-Donor Kidney Transplant.
LID - 10.3390/cells8080847 [doi]
LID - 847
AB  - Human leukocyte antigen (HLA)-E is important for the regulation of anti-viral 
      immunity. BK polyomavirus (BKPyV) reactivation after kidney transplant is a 
      serious complication that can result in BKPyV-associated nephropathy (PyVAN) and 
      subsequent allograft loss. To elucidate whether HLA-E polymorphisms influence 
      BKPyV replication and nephropathy, we determined the HLA-E genotype of 278 living 
      donor and recipient pairs. A total of 44 recipients suffered from BKPyV 
      replication, and 11 of these developed PyVAN. Homozygosity of the recipients for 
      the HLA-E*01:01 genotype was associated with the protection against PyVAN after 
      transplant (p = 0.025, OR 0.09, CI [95%] 0.83-4.89). Considering the time course 
      of the occurrence of nephropathy, recipients with PyVAN were more likely to carry 
      the HLA-E*01:03 allelic variant than those without PyVAN (Kaplan-Meier analysis p 
      = 0.03; OR = 4.25; CI (95%) 1.11-16.23). Our findings suggest that a 
      predisposition based on a defined HLA-E genotype is associated with an increased 
      susceptibility to develop PyVAN. Thus, assessing HLA-E polymorphisms may enable 
      physicians to identify patients being at an increased risk of this viral 
      complication.
FAU - Rohn, Hana
AU  - Rohn H
AD  - Department of Infectious Diseases, West German Centre for Infectious Diseases 
      (WZI), University Hospital Essen, University Duisburg-Essen, 45147 Essen, 
      Germany. hana.rohn@uk-essen.de.
FAU - Michita, Rafael Tomoya
AU  - Michita RT
AUID- ORCID: 0000-0003-3156-9382
AD  - Institute for Transfusion Medicine, University Hospital Essen, University 
      Duisburg-Essen, 45147 Essen, Germany.
AD  - Post-Graduation Program in Genetics and Molecular Biology, Genetics Department, 
      Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 91501-970, 
      Brazil.
FAU - Schramm, Sabine
AU  - Schramm S
AD  - Institute for Transfusion Medicine, University Hospital Essen, University 
      Duisburg-Essen, 45147 Essen, Germany.
FAU - Dolff, Sebastian
AU  - Dolff S
AD  - Department of Infectious Diseases, West German Centre for Infectious Diseases 
      (WZI), University Hospital Essen, University Duisburg-Essen, 45147 Essen, 
      Germany.
FAU - Gackler, Anja
AU  - Gackler A
AD  - Department of Nephrology, University Hospital Essen, University Duisburg-Essen, 
      45147 Essen, Germany.
FAU - Korth, Johannes
AU  - Korth J
AUID- ORCID: 0000-0003-4898-0389
AD  - Department of Nephrology, University Hospital Essen, University Duisburg-Essen, 
      45147 Essen, Germany.
FAU - Heinemann, Falko M
AU  - Heinemann FM
AD  - Institute for Transfusion Medicine, University Hospital Essen, University 
      Duisburg-Essen, 45147 Essen, Germany.
FAU - Wilde, Benjamin
AU  - Wilde B
AD  - Department of Nephrology, University Hospital Essen, University Duisburg-Essen, 
      45147 Essen, Germany.
FAU - Trilling, Mirko
AU  - Trilling M
AUID- ORCID: 0000-0003-3659-3541
AD  - Institute for Virology, University Hospital Essen, University Duisburg-Essen, 
      45147 Essen, Germany.
FAU - Horn, Peter A
AU  - Horn PA
AD  - Institute for Transfusion Medicine, University Hospital Essen, University 
      Duisburg-Essen, 45147 Essen, Germany.
FAU - Kribben, Andreas
AU  - Kribben A
AD  - Department of Nephrology, University Hospital Essen, University Duisburg-Essen, 
      45147 Essen, Germany.
FAU - Witzke, Oliver
AU  - Witzke O
AD  - Department of Infectious Diseases, West German Centre for Infectious Diseases 
      (WZI), University Hospital Essen, University Duisburg-Essen, 45147 Essen, 
      Germany.
FAU - Rebmann, Vera
AU  - Rebmann V
AUID- ORCID: 0000-0003-4660-3870
AD  - Institute for Transfusion Medicine, University Hospital Essen, University 
      Duisburg-Essen, 45147 Essen, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190807
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Kidney Diseases/*prevention & control
MH  - *Kidney Transplantation
MH  - Living Donors
MH  - Male
MH  - Middle Aged
MH  - *Polyomavirus Infections/genetics/prevention & control
MH  - HLA-E Antigens
PMC - PMC6721664
OTO - NOTNLM
OT  - BK virus
OT  - human leukocyte antigen-E
OT  - kidney transplantation
OT  - nephropathy
OT  - polyomavirus
COIS- The authors declare no conflict of interest.
EDAT- 2019/08/10 06:00
MHDA- 2020/05/12 06:00
PMCR- 2019/08/01
CRDT- 2019/08/10 06:00
PHST- 2019/06/22 00:00 [received]
PHST- 2019/07/26 00:00 [revised]
PHST- 2019/08/06 00:00 [accepted]
PHST- 2019/08/10 06:00 [entrez]
PHST- 2019/08/10 06:00 [pubmed]
PHST- 2020/05/12 06:00 [medline]
PHST- 2019/08/01 00:00 [pmc-release]
AID - cells8080847 [pii]
AID - cells-08-00847 [pii]
AID - 10.3390/cells8080847 [doi]
PST - epublish
SO  - Cells. 2019 Aug 7;8(8):847. doi: 10.3390/cells8080847.