PMID- 31396033
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231104
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 13
DP  - 2019
TI  - Disrupted Regional Cerebral Blood Flow, Functional Activity and Connectivity in 
      Alzheimer's Disease: A Combined ASL Perfusion and Resting State fMRI Study.
PG  - 738
LID - 10.3389/fnins.2019.00738 [doi]
LID - 738
AB  - Recent studies have demonstrated a close relationship between regional cerebral 
      blood flow (rCBF) and resting state functional connectivity changes in normal 
      healthy people. However, little is known about the parameter changes in the most 
      vulnerable regions in Alzheimer's disease (AD). Forty AD patients and 30 healthy 
      controls participated in this study. The data of resting-state perfusion and 
      functional magnetic resonance imaging (fMRI) was collected. By using voxel-wise 
      arterial spin labeling (ASL) perfusion, we identified several regions of altered 
      rCBF in AD patients. Then, by using resting state fMRI analysis, including 
      amplitude low frequency fluctuation (ALFF) and seed-based functional 
      connectivity, we investigated the changes of functional activity and connectivity 
      among the identified rCBF regions. We extracted cognition-related parameters and 
      searched for a sensitive biomarker to differentiate the AD patients from the 
      normal controls (NC). Compared with controls, AD patients showed special 
      disruptions in rCBF, which were mainly located in the left posterior cingulate 
      cortex (PCC), the left and right dorsolateral prefrontal cortex (DLPFC), the left 
      inferior parietal lobule (IPL), the right middle temporal gyrus (MTG), the left 
      middle occipital gyrus (MOG), and the left precuneus (PCu). ALFF was performed 
      based on the seven regions identified by the ASL method, and AD patients 
      presented significantly decreased ALFF in the left PCC, left IPL, right MTG, left 
      MOG, and left PCu and increased ALFF in the bilateral DLPFC. We constituted the 
      network based on the seven regions and found that there was decreased 
      connectivity among the identified regions in the AD patients, which predicted a 
      disruption in the default mode network (DMN), executive control network (ECN) and 
      visual network (VN). Furthermore, these abnormal parameters are closely 
      associated with cognitive performances in AD patients. We combined the rCBF and 
      ALFF value of PCC/PCu as a biomarker to differentiate the two groups and reached 
      a sensitivity of 85.3% and a specificity of 88.5%. Our findings suggested that 
      there was disrupted rCBF, functional activity and connectivity in specific 
      cognition-related regions in Alzheimer's disease, which can be used as a valuable 
      imaging biomarker for the diagnosis of AD.
FAU - Zheng, Weimin
AU  - Zheng W
AD  - Department of Radiology, Aerospace Center Hospital, Beijing, China.
FAU - Cui, Bin
AU  - Cui B
AD  - Department of Radiology, Aerospace Center Hospital, Beijing, China.
FAU - Han, Ying
AU  - Han Y
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
FAU - Song, Haiqing
AU  - Song H
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
FAU - Li, Kuncheng
AU  - Li K
AD  - Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
AD  - Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, 
      Beijing, China.
FAU - He, Yong
AU  - He Y
AD  - State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal 
      University, Beijing, China.
AD  - Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal 
      University, Beijing, China.
AD  - IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 
      China.
FAU - Wang, Zhiqun
AU  - Wang Z
AD  - Department of Radiology, Aerospace Center Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20190724
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC6668217
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - amplitude low frequency fluctuation
OT  - arterial spin labeling
OT  - functional connectivity
OT  - regional cerebral blood flow
OT  - resting state fMRI
EDAT- 2019/08/10 06:00
MHDA- 2019/08/10 06:01
PMCR- 2019/01/01
CRDT- 2019/08/10 06:00
PHST- 2019/02/17 00:00 [received]
PHST- 2019/07/02 00:00 [accepted]
PHST- 2019/08/10 06:00 [entrez]
PHST- 2019/08/10 06:00 [pubmed]
PHST- 2019/08/10 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2019.00738 [doi]
PST - epublish
SO  - Front Neurosci. 2019 Jul 24;13:738. doi: 10.3389/fnins.2019.00738. eCollection 
      2019.