PMID- 31396083
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 10
DP  - 2019
TI  - Rhizoma coptidis as a Potential Treatment Agent for Type 2 Diabetes Mellitus and 
      the Underlying Mechanisms: A Review.
PG  - 805
LID - 10.3389/fphar.2019.00805 [doi]
LID - 805
AB  - Diabetes mellitus, especially type 2 diabetes mellitus (T2DM), has become a 
      significant public health burden. Rhizoma coptidis (RC), known as Huang Lian, is 
      widely used for treating diabetes in China. The bioactive compounds of RC, 
      especially alkaloids, have the potential to suppress T2DM-induced lesions, 
      including diabetic vascular dysfunction, diabetic heart disease, diabetic 
      hyperlipidemia, diabetic nephropathy, diabetic encephalopathy, diabetic 
      osteopathy, diabetic enteropathy, and diabetic retinopathy. This review 
      summarizes the effects of RC and its bioactive compounds on T2DM and T2DM 
      complications. Less research has been conducted on non-alkaloid fractions of RC, 
      which may exert synergistic action with alkaloids. Moreover, we summarized the 
      pharmacokinetic properties and structure-activity relationships of RC on T2DM 
      with reference to extant literature and showed clearly that RC has potential 
      therapeutic effect on T2DM.
FAU - Ran, Qian
AU  - Ran Q
AD  - College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 
      China.
FAU - Wang, Jin
AU  - Wang J
AD  - College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 
      China.
FAU - Wang, Lin
AU  - Wang L
AD  - College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 
      China.
FAU - Zeng, Hai-Rong
AU  - Zeng HR
AD  - College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 
      China.
FAU - Yang, Xiang-Bo
AU  - Yang XB
AD  - Ya'an Xun Kang Pharmaceutical Co., Ltd, Ya'an, China.
FAU - Huang, Qin-Wan
AU  - Huang QW
AD  - College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 
      China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190722
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC6661542
OTO - NOTNLM
OT  - Huang Lian
OT  - Rhizoma coptidis
OT  - complications
OT  - ethnopharmacology
OT  - type 2 diabetes mellitus
EDAT- 2019/08/10 06:00
MHDA- 2019/08/10 06:01
PMCR- 2019/07/22
CRDT- 2019/08/10 06:00
PHST- 2018/11/03 00:00 [received]
PHST- 2019/06/21 00:00 [accepted]
PHST- 2019/08/10 06:00 [entrez]
PHST- 2019/08/10 06:00 [pubmed]
PHST- 2019/08/10 06:01 [medline]
PHST- 2019/07/22 00:00 [pmc-release]
AID - 10.3389/fphar.2019.00805 [doi]
PST - epublish
SO  - Front Pharmacol. 2019 Jul 22;10:805. doi: 10.3389/fphar.2019.00805. eCollection 
      2019.