PMID- 31396261
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 10
DP  - 2019
TI  - ACTB Variants Confer the Genetic Susceptibility to Diabetic Kidney Disease in a 
      Han Chinese Population.
PG  - 663
LID - 10.3389/fgene.2019.00663 [doi]
LID - 663
AB  - Beta-actin (ACTB) loss-of-function mutations result in a pleiotropic 
      developmental disorder of kidney. The present study aims to explore whether the 
      common variants at the ACTB gene contribute to diabetic kidney disease (DKD) 
      susceptibility in patients with type 2 diabetes mellitus (T2DM). From the 
      baseline population of 20,340 diabetic patients, 1,510 DKD cases and 1,510 
      age-matched T2DM controls were selected. All subjects were Han Chinese. Three 
      tagging single nucleotide polymorphisms (SNPs), rs852423, rs852426, and 
      rs2966449, at the ACTB gene were genotyped. Logistic regression was performed to 
      estimate the association with DKD. SNPs, rs852426 and rs2966449, were 
      significantly associated with DKD [additive model; odds ratio (OR), 1.217 and 
      1.151; P = 0.001 and 0.018, respectively]. The association of rs852426 with DKD 
      still remained statistically significant after Bonferroni correction and 
      particularly significant in the population older than 70 years rather than the 70 
      years or younger (P = 0.047 for heterogeneity test). Furthermore, the association 
      of rs852426 with DKD was observed in populations of male and females without 
      smoking, drinking, and with duration for T2DM 10-20 years. The association of 
      rs2966449 with DKD was also found in the populations older than 70 years, male, 
      not smoking, not drinking, and with duration for T2DM over 20 years. The 
      estimated glomerular filtration rate (eGFR) levels of the individuals with TT or 
      CC genotypes of rs2966449 were significantly lower than that of TC genotype in 
      DKD cases (P = 0.021). The present study provides evidence that the ACTB 
      variants, i.e., rs852426 and rs2966449, may confer the genetic susceptibility to 
      DKD in a Han Chinese population.
FAU - Li, Mengxia
AU  - Li M
AD  - Department of Epidemiology, School of Public Health, Nanjing Medical University, 
      Nanjing, China.
FAU - Wu, Ming
AU  - Wu M
AD  - Department of Non-communicable Chronic Disease Control, Jiangsu Provincial Center 
      for Disease Control and Prevention, Nanjing, China.
FAU - Qin, Yu
AU  - Qin Y
AD  - Department of Non-communicable Chronic Disease Control, Jiangsu Provincial Center 
      for Disease Control and Prevention, Nanjing, China.
FAU - Zhou, Jinyi
AU  - Zhou J
AD  - Department of Non-communicable Chronic Disease Control, Jiangsu Provincial Center 
      for Disease Control and Prevention, Nanjing, China.
FAU - Su, Jian
AU  - Su J
AD  - Department of Chronic Disease Prevention and Control, Huai'an City Center for 
      Disease Control and Prevention, Huai'an, China.
FAU - Pan, Enchun
AU  - Pan E
AD  - Department of Chronic Disease Prevention and Control, Huai'an City Center for 
      Disease Control and Prevention, Huai'an, China.
FAU - Zhang, Qin
AU  - Zhang Q
AD  - Department of Chronic Disease Prevention and Control, Huai'an City Center for 
      Disease Control and Prevention, Huai'an, China.
FAU - Zhang, Ning
AU  - Zhang N
AD  - Changshu County Center for Disease Control and Prevention, Suzhou, China.
FAU - Sheng, Hongyan
AU  - Sheng H
AD  - Changshu County Center for Disease Control and Prevention, Suzhou, China.
FAU - Dong, Jiayi
AU  - Dong J
AD  - Department of Epidemiology, School of Public Health, Nanjing Medical University, 
      Nanjing, China.
FAU - Tong, Ye
AU  - Tong Y
AD  - Department of Epidemiology, School of Public Health, Nanjing Medical University, 
      Nanjing, China.
FAU - Shen, Chong
AU  - Shen C
AD  - Department of Epidemiology, School of Public Health, Nanjing Medical University, 
      Nanjing, China.
LA  - eng
PT  - Journal Article
DEP - 20190723
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC6664243
OTO - NOTNLM
OT  - ACTB gene
OT  - diabetic kidney disease
OT  - estimated glomerular filtration rate
OT  - single nucleotide polymorphisms
OT  - type 2 diabetes mellitus
EDAT- 2019/08/10 06:00
MHDA- 2019/08/10 06:01
PMCR- 2019/07/23
CRDT- 2019/08/10 06:00
PHST- 2019/02/09 00:00 [received]
PHST- 2019/06/24 00:00 [accepted]
PHST- 2019/08/10 06:00 [entrez]
PHST- 2019/08/10 06:00 [pubmed]
PHST- 2019/08/10 06:01 [medline]
PHST- 2019/07/23 00:00 [pmc-release]
AID - 10.3389/fgene.2019.00663 [doi]
PST - epublish
SO  - Front Genet. 2019 Jul 23;10:663. doi: 10.3389/fgene.2019.00663. eCollection 2019.