PMID- 31397466
OWN - NLM
STAT- MEDLINE
DCOM- 20200909
LR  - 20200909
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 7
IP  - 35
DP  - 2019 Sep 11
TI  - High-efficiency fluorescent and magnetic multimodal probe for long-term 
      monitoring and deep penetration imaging of tumors.
PG  - 5345-5351
LID - 10.1039/c9tb00638a [doi]
AB  - High-quality multimodal imaging requires exogenous contrast agents with high 
      sensitivity, spatial-temporal resolution, and high penetration depth for the 
      accurate diagnosis and surveillance of cancer. Herein, we design a highly 
      efficient fluorescent and magnetic multimodal probe by doping fluorescent 
      molecule 2-(4-bromophenyl)-3-(4-(4-(diphenylamino)styryl)phenyl)fumaronitrile 
      (TB) with near-infrared (NIR) fluorescent emission (714 nm) and superparamagnetic 
      iron oxide (SPIO) into a polystyrene-polyethylene glycol (PS-PEG) matrix to form 
      TB/SPIO@PS-PEG nanoparticles (TSP NPs). The as-prepared TSP NPs exhibit red 
      aggregation-induced emission (AIE) with a maximum wavelength at 655 nm and high 
      fluorescence quantum yield (QY) of 14.6%, facilitating the improvement of 
      sensitivity and signal-to-background ratio for fluorescence molecular imaging 
      (FMI). Phase behavior investigation of the TB/SPIO@PS-PEG probe system by 
      Flory-Huggins lattice theory elucidates the highly efficient fluorescence of the 
      multimodal probe, originating from the poor miscibility between TB and SPIO. 
      Meanwhile, the TSP NPs possess good superparamagnetism and relaxivity and can 
      thus be used as appropriate magnetic contrast agents for magnetic resonance 
      imaging (MRI) and magnetic particle imaging (MPI). In addition, the good 
      biocompatibility and photostability of the TSP NPs make them suitable for 
      long-term monitoring. In vivo fluorescence imaging results indicate that the TSP 
      NPs can facilitate monitoring of subcutaneous tumor growth for more than 24 days 
      in a real-time manner. Multimodal imaging consisting of FMI, MRI, and MPI reveals 
      that TSP NPs can monitor a liver tumor in situ with almost unlimited depth in 
      tissues and high temporal-spatial resolution. As a multimodal probe, the TSP NPs 
      manifest obvious synergistic advantages of long-term monitoring and high 
      penetration depth and hold great prospects in tumor imaging.
FAU - Meng, Lingchen
AU  - Meng L
AD  - State Key Laboratory of Supramolecular Structure and Materials, Jilin University, 
      Changchun, 130012, China. wjtian@jlu.edu.cn.
FAU - Ma, Xibo
AU  - Ma X
AD  - Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of 
      Sciences, Beijing, 100190, China and The University of Chinese Academy of 
      Sciences, Beijing, 100049, China.
FAU - Jiang, Shan
AU  - Jiang S
AD  - State Key Laboratory of Supramolecular Structure and Materials, Jilin University, 
      Changchun, 130012, China. wjtian@jlu.edu.cn.
FAU - Ji, Guang
AU  - Ji G
AD  - State Key Laboratory of Supramolecular Structure and Materials, Jilin University, 
      Changchun, 130012, China. wjtian@jlu.edu.cn.
FAU - Han, Wenkun
AU  - Han W
AD  - State Key Laboratory of Supramolecular Structure and Materials, Jilin University, 
      Changchun, 130012, China. wjtian@jlu.edu.cn.
FAU - Xu, Bin
AU  - Xu B
AUID- ORCID: 0000-0002-0423-925X
AD  - State Key Laboratory of Supramolecular Structure and Materials, Jilin University, 
      Changchun, 130012, China. wjtian@jlu.edu.cn.
FAU - Tian, Jie
AU  - Tian J
AD  - Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of 
      Sciences, Beijing, 100190, China and The University of Chinese Academy of 
      Sciences, Beijing, 100049, China.
FAU - Tian, Wenjing
AU  - Tian W
AUID- ORCID: 0000-0001-5766-8050
AD  - State Key Laboratory of Supramolecular Structure and Materials, Jilin University, 
      Changchun, 130012, China. wjtian@jlu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
RN  - 0 (Contrast Media)
RN  - 0 (Ferric Compounds)
RN  - 0 (Fumarates)
RN  - 0 (Magnetite Nanoparticles)
RN  - 764-42-1 (fumaronitrile)
SB  - IM
MH  - Animals
MH  - Cell Line, Tumor
MH  - Contrast Media/*chemistry
MH  - Ferric Compounds/chemistry
MH  - Fumarates/chemistry
MH  - Liver Neoplasms, Experimental/*diagnostic imaging
MH  - Magnetic Resonance Imaging/methods
MH  - Magnetite Nanoparticles/chemistry
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Optical Imaging/methods
EDAT- 2019/08/10 06:00
MHDA- 2020/09/10 06:00
CRDT- 2019/08/10 06:00
PHST- 2019/08/10 06:00 [pubmed]
PHST- 2020/09/10 06:00 [medline]
PHST- 2019/08/10 06:00 [entrez]
AID - 10.1039/c9tb00638a [doi]
PST - ppublish
SO  - J Mater Chem B. 2019 Sep 11;7(35):5345-5351. doi: 10.1039/c9tb00638a.