PMID- 31397769
OWN - NLM
STAT- MEDLINE
DCOM- 20201111
LR  - 20201111
IS  - 1932-751X (Electronic)
IS  - 1932-7501 (Linking)
VI  - 39
IP  - 6
DP  - 2019 Nov
TI  - Exercise Rehabilitation Improves Cardiac Volumes and Functional Capacity in 
      Patients With Endomyocardial Fibrosis: A RANDOMIZED CONTROLLED TRIAL.
PG  - 373-380
LID - 10.1097/HCR.0000000000000445 [doi]
AB  - PURPOSE: Endomyocardial fibrosis (EMF) is a restrictive cardiomyopathy associated 
      with low functional capacity and high mortality rates. Exercise training has been 
      proved to be a nonpharmacological treatment of cardiovascular diseases. 
      Therefore, the purpose of this study was to determine the effects of exercise 
      rehabilitation in EMF patients. METHODS: Twenty-two EMF patients, functional 
      classes II and III (New York Heart Association [NYHA]), were randomized to the 
      control (C-EMF) or exercise rehabilitation (Rehab-EMF) group. Patients in the 
      Rehab-EMF group underwent 4 mo of exercise rehabilitation, whereas patients in 
      the C-EMF group were instructed to maintain their usual daily routine. Peak 
      oxygen uptake ((Equation is included in full-text article.)O2), cardiac function, 
      and quality of life were evaluated. All assessments were performed at baseline 
      and after 4 mo. RESULTS: After 4 mo of rehabilitation, peak (Equation is included 
      in full-text article.)O2 increased in the Rehab-EMF group (17.4 +/- 3.0 to 19.7 +/- 
      4.4 mL/kg/min, P < .001), whereas the C-EMF group showed no difference (15.3 +/- 
      3.0 to 15.0 +/- 2.0 mL/kg/min, P = .87). Also, post-intervention, peak (Equation is 
      included in full-text article.)O2 in the Rehab-EMF group was greater than that in 
      the C-EMF group (P < .001). Furthermore, the Rehab-EMF group, when compared to 
      the C-EMF group, showed an increase in left ventricular end-diastolic volume 
      (102.1 +/- 64.6 to 136.2 +/- 75.8 mL vs 114.4 +/- 55.0 to 100.4 +/- 49.9 mL, P < .001, 
      respectively) and decrease in left atrial diastolic volume (69.0 +/- 33.0 to 34.9 +/- 
      15.0 mL vs 44.6 +/- 21.0 to 45.6 +/- 23.0 mL, P < .001, respectively). 
      Quality-of-life scores also improved in the Rehab-EMF group, whereas the C-EMF 
      group showed no change (45 +/- 23 to 27 +/- 15 vs 47 +/- 15 to 45 +/- 17, P < .001, 
      respectively). CONCLUSION: Exercise rehabilitation is a nonpharmacological 
      intervention that improves functional capacity, cardiac volumes, and quality of 
      life in EMF patients after endocardial resection surgery. In addition, exercise 
      rehabilitation should be prescribed to EMF patients to improve their clinical 
      condition.
FAU - Sayegh, Ana Luiza Carrari
AU  - Sayegh ALC
AD  - Clinical Unit of Cardiomyopathy, Heart Institute (InCor) (Drs Sayegh and Mady), 
      Cardiovascular Rehabilitation and Exercise Physiology Unit, Heart Institute 
      (InCor-HC-FMUSP) (Drs dos Santos, de Oliveira, and Alves and Messrs Rondon and de 
      Souza), and Clinical Unit of Heart Failure, Heart Institute (InCor) (Dr Salemi), 
      University of Sao Paulo Medical School, Sao Paulo, Brazil.
FAU - Dos Santos, Marcelo R
AU  - Dos Santos MR
FAU - Rondon, Eduardo
AU  - Rondon E
FAU - de Oliveira, Patricia
AU  - de Oliveira P
FAU - de Souza, Francis R
AU  - de Souza FR
FAU - Salemi, Vera M C
AU  - Salemi VMC
FAU - Alves, Maria-Janieire de N N
AU  - Alves MNN
FAU - Mady, Charles
AU  - Mady C
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cardiopulm Rehabil Prev
JT  - Journal of cardiopulmonary rehabilitation and prevention
JID - 101291247
SB  - IM
MH  - Cardiac Volume/*physiology
MH  - Echocardiography/methods
MH  - Endomyocardial Fibrosis/physiopathology/*rehabilitation
MH  - Exercise Therapy/*methods
MH  - Female
MH  - Heart/diagnostic imaging/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Quality of Life
EDAT- 2019/08/10 06:00
MHDA- 2020/11/12 06:00
CRDT- 2019/08/10 06:00
PHST- 2019/08/10 06:00 [pubmed]
PHST- 2020/11/12 06:00 [medline]
PHST- 2019/08/10 06:00 [entrez]
AID - 10.1097/HCR.0000000000000445 [doi]
PST - ppublish
SO  - J Cardiopulm Rehabil Prev. 2019 Nov;39(6):373-380. doi: 
      10.1097/HCR.0000000000000445.