PMID- 31398884
OWN - NLM
STAT- MEDLINE
DCOM- 20200205
LR  - 20231104
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 11
IP  - 8
DP  - 2019 Aug 8
TI  - Curcumin and Type 2 Diabetes Mellitus: Prevention and Treatment.
LID - 10.3390/nu11081837 [doi]
LID - 1837
AB  - Type 2 diabetes mellitus (T2DM) is an ensemble of metabolic diseases that has 
      reached pandemic dimensions all over the world. The multifactorial nature of the 
      pathology makes patient management, which includes lifelong drug therapy and 
      lifestyle modification, extremely challenging. It is well known that T2DM is a 
      preventable disease, therefore lowering the incidence of new T2DM cases could be 
      a key strategy to reduce the global impact of diabetes. Currently, there is 
      growing evidence on the efficacy of the use of medicinal plants supplements for 
      T2DM prevention and management. Among these medicinal plants, curcumin is gaining 
      a growing interest in the scientific community. Curcumin is a bioactive molecule 
      present in the rhizome of the Curcuma longa plant, also known as turmeric. 
      Curcumin has different pharmacological and biological effects that have been 
      described by both in vitro and in vivo studies, and include antioxidant, 
      cardio-protective, anti-inflammatory, anti-microbial, nephro-protective, 
      anti-neoplastic, hepato-protective, immunomodulatory, hypoglycaemic and 
      anti-rheumatic effects. In animal models, curcumin extract delays diabetes 
      development, improves beta-cell functions, prevents beta-cell death, and decreases 
      insulin resistance. The present review focuses on pre-clinical and clinical 
      trials on curcumin supplementation in T2DM and discusses the peculiar mechanisms 
      by which curcumin might ameliorate diabetes management.
FAU - Pivari, Francesca
AU  - Pivari F
AUID- ORCID: 0000-0002-2277-6833
AD  - Department of Health Sciences, University of Milan, Via A. Di Rudini, 8, 20142 
      Milan, Italy. francesca.pivari@unimi.it.
FAU - Mingione, Alessandra
AU  - Mingione A
AD  - Department of Health Sciences, University of Milan, Via A. Di Rudini, 8, 20142 
      Milan, Italy.
FAU - Brasacchio, Caterina
AU  - Brasacchio C
AD  - Department of Health Sciences, University of Milan, Via A. Di Rudini, 8, 20142 
      Milan, Italy.
FAU - Soldati, Laura
AU  - Soldati L
AD  - Department of Health Sciences, University of Milan, Via A. Di Rudini, 8, 20142 
      Milan, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190808
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Plant Extracts)
RN  - 856YO1Z64F (turmeric extract)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Clinical Trials as Topic
MH  - Curcuma
MH  - Curcumin/*pharmacology
MH  - Diabetes Mellitus, Type 2/*drug therapy/*prevention & control
MH  - Humans
MH  - Hypoglycemic Agents/*pharmacology
MH  - Phytotherapy/*methods
MH  - Plant Extracts/*pharmacology
MH  - Plants, Medicinal
PMC - PMC6723242
OTO - NOTNLM
OT  - antioxidant activity
OT  - clinical trials
OT  - curcumin
OT  - inflammation
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2019/08/11 06:00
MHDA- 2020/02/06 06:00
PMCR- 2019/08/01
CRDT- 2019/08/11 06:00
PHST- 2019/07/01 00:00 [received]
PHST- 2019/07/30 00:00 [revised]
PHST- 2019/08/05 00:00 [accepted]
PHST- 2019/08/11 06:00 [entrez]
PHST- 2019/08/11 06:00 [pubmed]
PHST- 2020/02/06 06:00 [medline]
PHST- 2019/08/01 00:00 [pmc-release]
AID - nu11081837 [pii]
AID - nutrients-11-01837 [pii]
AID - 10.3390/nu11081837 [doi]
PST - epublish
SO  - Nutrients. 2019 Aug 8;11(8):1837. doi: 10.3390/nu11081837.