PMID- 31400473
OWN - NLM
STAT- MEDLINE
DCOM- 20210910
LR  - 20210910
IS  - 1528-8447 (Electronic)
IS  - 1526-5900 (Linking)
VI  - 21
IP  - 3-4
DP  - 2020 Mar-Apr
TI  - Altered Spontaneous Activity and Functional Connectivity in the Posterior Pons of 
      Patients With Migraine Without Aura.
PG  - 347-354
LID - S1526-5900(18)30904-0 [pii]
LID - 10.1016/j.jpain.2019.08.001 [doi]
AB  - The brainstem has been discussed as the main player in the pathogenesis of 
      migraine. Dysfunctional brainstem nuclei and their abnormal connections to other 
      key brain centers may contribute to headache and other symptoms of migraine. In 
      the present study, 32 patients with migraine without aura (MWoA) and 32 age- and 
      sex-matched healthy controls (HCs) underwent resting-state fMRI scans. We used 
      masked independent analysis (mICA) to investigate whether patients with MWoA 
      exhibited abnormal brainstem nuclei-cortical functional connectivity (FC). The 
      mICA can suppress adjacent physiological noise and prevent results from being 
      driven by the much stronger signals of the surrounding structures. Regional 
      homogeneity (ReHo) was used to investigate whether the brainstem regions with 
      abnormal FC to other brain areas exhibited abnormal regional neuronal activity. 
      Patients with MWoA showed significantly weaker FC between the posterior pons and 
      the left superior parietal lobule, the left middle temporal gyrus, and the left 
      middle frontal gyrus. Furthermore, patients with MWoA exhibited significantly 
      decreased ReHo values in the posterior pons compared with HCs, and the posterior 
      pons ReHo value was significantly negatively correlated with HIT-6 scores in the 
      MWoA group. Patients with MWoA exhibited functional abnormalities in the 
      posterior pons and weakened connections between the posterior pons and several 
      key cortical brain areas involved in pain processing during the resting state. 
      PERSPECTIVE: This study provided increased evidence that the pons is involved in 
      the pathophysiological mechanism of migraine, and weakened connections suggest 
      that the touch and pain sensation of migraine sufferers may not be properly 
      relayed to cortical processing areas, which may be associated with the 
      pathogenesis of MWoA.
CI  - Copyright (c) 2019 United States Association for the Study of Pain, Inc. Published 
      by Elsevier Inc. All rights reserved.
FAU - Qin, Zhaoxia
AU  - Qin Z
AD  - Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, School 
      of Physics and Materials Science, East China Normal University, Shanghai, China.
FAU - He, Xin-Wei
AU  - He XW
AD  - Department of Neurology and Jiuyuan Municipal Stroke Center, Shanghai Ninth 
      People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China; Clinical Research Center, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
FAU - Zhang, Jilei
AU  - Zhang J
AD  - Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, School 
      of Physics and Materials Science, East China Normal University, Shanghai, China.
FAU - Xu, Shuai
AU  - Xu S
AD  - Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, School 
      of Physics and Materials Science, East China Normal University, Shanghai, China.
FAU - Li, Ge-Fei
AU  - Li GF
AD  - Department of Neurology and Jiuyuan Municipal Stroke Center, Shanghai Ninth 
      People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China; Clinical Research Center, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
FAU - Su, Jingjing
AU  - Su J
AD  - Department of Neurology and Jiuyuan Municipal Stroke Center, Shanghai Ninth 
      People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
FAU - Shi, Yan-Hui
AU  - Shi YH
AD  - Department of Neurology and Jiuyuan Municipal Stroke Center, Shanghai Ninth 
      People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China; Clinical Research Center, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
FAU - Ban, Shiyu
AU  - Ban S
AD  - Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, School 
      of Physics and Materials Science, East China Normal University, Shanghai, China.
FAU - Hu, Yue
AU  - Hu Y
AD  - Department of Neurology and Jiuyuan Municipal Stroke Center, Shanghai Ninth 
      People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China; Clinical Research Center, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
FAU - Liu, Yi-Sheng
AU  - Liu YS
AD  - Department of Neurology and Jiuyuan Municipal Stroke Center, Shanghai Ninth 
      People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
FAU - Zhuang, Mei-Ting
AU  - Zhuang MT
AD  - Department of Neurology and Jiuyuan Municipal Stroke Center, Shanghai Ninth 
      People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
FAU - Zhao, Rong
AU  - Zhao R
AD  - Department of Neurology and Jiuyuan Municipal Stroke Center, Shanghai Ninth 
      People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China; Clinical Research Center, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
FAU - Shen, Xiao-Lei
AU  - Shen XL
AD  - Department of Neurology and Jiuyuan Municipal Stroke Center, Shanghai Ninth 
      People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
FAU - Li, Jianqi
AU  - Li J
AD  - Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, School 
      of Physics and Materials Science, East China Normal University, Shanghai, China.
FAU - Liu, Jian-Ren
AU  - Liu JR
AD  - Department of Neurology and Jiuyuan Municipal Stroke Center, Shanghai Ninth 
      People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China; Clinical Research Center, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
FAU - Du, Xiaoxia
AU  - Du X
AD  - Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, School 
      of Physics and Materials Science, East China Normal University, Shanghai, China. 
      Electronic address: xxdu@phy.ecnu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190807
PL  - United States
TA  - J Pain
JT  - The journal of pain
JID - 100898657
SB  - IM
MH  - Adult
MH  - Cerebral Cortex/diagnostic imaging/*physiopathology
MH  - *Connectome
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Migraine without Aura/diagnostic imaging/*physiopathology
MH  - Pons/diagnostic imaging/*physiopathology
MH  - Young Adult
OTO - NOTNLM
OT  - Pons
OT  - functional MRI
OT  - functional connectivity
OT  - migraine
OT  - regional homogeneity
EDAT- 2019/08/11 06:00
MHDA- 2021/09/11 06:00
CRDT- 2019/08/11 06:00
PHST- 2018/11/23 00:00 [received]
PHST- 2019/06/03 00:00 [revised]
PHST- 2019/08/02 00:00 [accepted]
PHST- 2019/08/11 06:00 [pubmed]
PHST- 2021/09/11 06:00 [medline]
PHST- 2019/08/11 06:00 [entrez]
AID - S1526-5900(18)30904-0 [pii]
AID - 10.1016/j.jpain.2019.08.001 [doi]
PST - ppublish
SO  - J Pain. 2020 Mar-Apr;21(3-4):347-354. doi: 10.1016/j.jpain.2019.08.001. Epub 2019 
      Aug 7.