PMID- 31403396
OWN - NLM
STAT- MEDLINE
DCOM- 20200624
LR  - 20200624
IS  - 1557-8518 (Electronic)
IS  - 1540-4196 (Linking)
VI  - 17
IP  - 9
DP  - 2019 Nov
TI  - The Further Negative Effect of Hyperuricemia on Left Ventricular Structure and 
      Function in Patients with Type 2 Diabetes Mellitus: A Transthoracic 3D Speckle 
      Tracking Imaging Study.
PG  - 436-443
LID - 10.1089/met.2019.0048 [doi]
AB  - Aims: The aims of this study were to explore the left ventricular (LV) structural 
      abnormality and its risk factors in type 2 diabetes mellitus (T2DM) patients with 
      or without hyperuricemia (HU) and to compare their LV function using 
      three-dimensional speckle tracking echocardiography (3DSTE). Methods: Eighty T2DM 
      patients with preserved LV ejection fraction were included, 40 of whom had HU as 
      co-morbidity. Forty age- and gender-matched controls were also recruited. The 
      risk factors and corresponding diagnostic values for LV remodeling (LVR) were, 
      respectively, determined using multifactor logistic regression and area under the 
      receiver operating characteristic curves (AUC). LV global longitudinal strain 
      (GLS), global circumferential strain (GCS), global area strain (GAS), and global 
      radial strain (GRS) were measured by 3DSTE. Results: LV morphology constituent 
      ratio showed significant differences among groups (P = 0.0001). Compared with the 
      controls, more abnormal LV patterns were found in the two T2DM groups, while LV 
      hypertrophy was the most prevalent in those with T2DM and HU. Fasting plasma 
      glucose and serum uric acid were two significant risk factors for LVR in T2DM 
      patients (AUC values: 0.678 and 0.672). The patients with T2DM alone had 
      significantly lower GLS than the controls (P < 0.05). The patients with T2DM and 
      HU had significantly lower GLS, GCS, GAS, and GRS than the controls (all 
      P < 0.01), and they also had significantly lower GLS, GCS, and GAS than the 
      patients with T2DM alone (all P < 0.05). Conclusions: Conventional 
      echocardiography combined with 3DSTE could detect subclinical LV structural 
      abnormality and dysfunction in T2DM patients with or without HU.
FAU - Wang, Qingqing
AU  - Wang Q
AD  - Department of Ultrasound, Affiliated Hospital of Southwest Medical University, 
      Luzhou, China.
FAU - Tan, Kaibin
AU  - Tan K
AD  - Department of Ultrasound, The Third Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Xia, Hongmei
AU  - Xia H
AD  - Department of Ultrasound, Xinqiao Hospital, The Third Military Medical 
      University, Chongqing, China.
FAU - Gao, Yunhua
AU  - Gao Y
AD  - Department of Ultrasound, Xinqiao Hospital, The Third Military Medical 
      University, Chongqing, China.
LA  - eng
PT  - Journal Article
DEP - 20190812
PL  - United States
TA  - Metab Syndr Relat Disord
JT  - Metabolic syndrome and related disorders
JID - 101150318
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*complications/diagnosis/epidemiology/physiopathology
MH  - Diabetic Angiopathies/complications/diagnosis/physiopathology
MH  - Echocardiography, Three-Dimensional/*methods
MH  - Female
MH  - Heart Ventricles/diagnostic imaging/physiopathology
MH  - Humans
MH  - Hyperuricemia/*complications/diagnosis/epidemiology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Ventricular Dysfunction, Left/*diagnosis/epidemiology/*etiology/physiopathology
MH  - Ventricular Function, Left/*physiology
OTO - NOTNLM
OT  - LV function
OT  - LV structural abnormality
OT  - hyperuricemia (HU)
OT  - risk factors
OT  - three-dimensional speckle tracking echocardiography (3DSTE)
OT  - type 2 diabetes mellitus (T2DM)
EDAT- 2019/08/14 06:00
MHDA- 2020/06/25 06:00
CRDT- 2019/08/13 06:00
PHST- 2019/08/14 06:00 [pubmed]
PHST- 2020/06/25 06:00 [medline]
PHST- 2019/08/13 06:00 [entrez]
AID - 10.1089/met.2019.0048 [doi]
PST - ppublish
SO  - Metab Syndr Relat Disord. 2019 Nov;17(9):436-443. doi: 10.1089/met.2019.0048. 
      Epub 2019 Aug 12.