PMID- 31404425
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 2590-1613 (Electronic)
IS  - 2590-1613 (Linking)
VI  - 3
DP  - 2019 Jul
TI  - Matrix metalloproteinases 3 polymorphism increases the risk of developing 
      advanced endometriosis and infertility: A case-control study.
PG  - 100041
LID - 10.1016/j.eurox.2019.100041 [doi]
LID - 100041
AB  - OBJECTIVE: Endometriosis has a complex and multifactorial pathology, and it is 
      considered one of the main causes of infertility nowadays. The angiogenic 
      process, which involves remodeling of extracellular matrix, is crucial for the 
      development of this disease, mainly by the action of the matrix metalloproteinase 
      3 (MMP-3). It is known that genetic factors can influence endometriosis, thus; we 
      investigated the role of MMP3 276G>A polymorphism as a risk factor for the 
      development of the disease and its symptoms. STUDY DESIGN: This case-control 
      study included 283 women with endometriosis (cases) and 217 women without the 
      disease (controls) who were submitted to laparoscopic or laparotomy surgery. 
      Real-time polymerase chain reaction performed by TaqMan system was applied for 
      all polymorphisms. A multivariate logistic regression was performed to evaluate 
      the association between polymorphism and endometriosis or clinical and 
      gynecological characteristics of the disease, using their respective odds ratios 
      (OR) and 95% confidence intervals (CI). RESULTS: The allelic frequency of the 
      MMP3 276 G > A polymorphism was 33.6% in controls and 40.3% in endometriosis 
      cases. The allelic distribution was significantly different between the two 
      (P = 0.03). The variant genotype of MMP3 276AA was associated with increased 
      endometriosis risk in the advanced endometriosis cases (OR: 2.08, 95% CI: 1.05 - 
      4.07 and OR: 1.87, 95% CI: 1.01 - 3.45). Regarding the symptoms, 
      endometriosis-related infertile women had a positive association with the 
      presence of MMP3 276 G > A polymorphism (OR: 3.13, 95% CI: 1.08-9.08 and OR: 
      3.30, 95% CI: 1.31 - 8.33). CONCLUSIONS: These findings suggest that the MMP3 
      276A polymorphism is involved with advanced endometriosis cases and infertility, 
      and these associations may implicate in the behavior of disease.
FAU - Cardoso, Jessica V
AU  - Cardoso JV
AD  - Programa de Pos-guaduacao em Saude Publica e Meio Ambiente, Escola Nacional de 
      Saude Publica, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
AD  - Laboratorio de Pesquisa de Ciencias Farmaceuticas, Unidade de Farmacia, Centro 
      Universitario Estadual da Zona Oeste, Rio de Janeiro, RJ, Brazil.
FAU - Machado, Daniel E
AU  - Machado DE
AD  - Laboratorio de Pesquisa de Ciencias Farmaceuticas, Unidade de Farmacia, Centro 
      Universitario Estadual da Zona Oeste, Rio de Janeiro, RJ, Brazil.
FAU - da Silva, Mayara C
AU  - da Silva MC
AD  - Programa de Pos-guaduacao em Saude Publica e Meio Ambiente, Escola Nacional de 
      Saude Publica, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
AD  - Laboratorio de Pesquisa de Ciencias Farmaceuticas, Unidade de Farmacia, Centro 
      Universitario Estadual da Zona Oeste, Rio de Janeiro, RJ, Brazil.
FAU - Berardo, Plinio T
AU  - Berardo PT
AD  - Servico de Ginecologia, Hospital Federal dos Servidores do Estado, Rio de 
      Janeiro, RJ, Brazil.
AD  - Departamento de Ginecologia, Faculdade de Medicina, Universidade Estacio de Sa, 
      Rio de Janeiro, RJ, Brazil.
FAU - Ferrari, Renato
AU  - Ferrari R
AD  - Instituto de Ginecologia, Hospital Moncorvo Filho, Universidade Federal do Rio de 
      Janeiro, Rio de Janeiro, RJ, Brazil.
FAU - Abrao, Mauricio S
AU  - Abrao MS
AD  - Secao de Endometriose, Divisao de Ginecologia, Hospital das Clinicas, Faculdade 
      de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
AD  - Divisao de Ginecologia, Beneficencia Portuguesa de Sao Paulo, Sao Paulo, SP, 
      Brazil.
FAU - Perini, Jamila A
AU  - Perini JA
AD  - Programa de Pos-guaduacao em Saude Publica e Meio Ambiente, Escola Nacional de 
      Saude Publica, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
AD  - Laboratorio de Pesquisa de Ciencias Farmaceuticas, Unidade de Farmacia, Centro 
      Universitario Estadual da Zona Oeste, Rio de Janeiro, RJ, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20190506
PL  - Netherlands
TA  - Eur J Obstet Gynecol Reprod Biol X
JT  - European journal of obstetrics & gynecology and reproductive biology: X
JID - 101750520
PMC - PMC6687389
OTO - NOTNLM
OT  - Angiogenesis
OT  - Endometriosis
OT  - Infertility
OT  - MMP3
OT  - Polymorphisms
EDAT- 2019/08/14 06:00
MHDA- 2019/08/14 06:01
PMCR- 2019/05/06
CRDT- 2019/08/13 06:00
PHST- 2019/02/12 00:00 [received]
PHST- 2019/05/03 00:00 [revised]
PHST- 2019/05/05 00:00 [accepted]
PHST- 2019/08/13 06:00 [entrez]
PHST- 2019/08/14 06:00 [pubmed]
PHST- 2019/08/14 06:01 [medline]
PHST- 2019/05/06 00:00 [pmc-release]
AID - S2590-1613(19)30076-6 [pii]
AID - 100041 [pii]
AID - 10.1016/j.eurox.2019.100041 [doi]
PST - epublish
SO  - Eur J Obstet Gynecol Reprod Biol X. 2019 May 6;3:100041. doi: 
      10.1016/j.eurox.2019.100041. eCollection 2019 Jul.