PMID- 31404750
OWN - NLM
STAT- MEDLINE
DCOM- 20200824
LR  - 20200824
IS  - 1532-3064 (Electronic)
IS  - 0954-6111 (Linking)
VI  - 156
DP  - 2019 Sep
TI  - Comparison of supplemental oxygen delivery by continuous versus demand based flow 
      systems in hypoxemic COPD patients - A randomized, single-blinded cross-over 
      study.
PG  - 26-32
LID - S0954-6111(19)30258-6 [pii]
LID - 10.1016/j.rmed.2019.08.001 [doi]
AB  - BACKGROUND: Supplemental oxygen is a recommended therapy option in stable 
      hypoxemic COPD patients. Often, supplemental oxygen is provided by continuous 
      flow (CF). However, demand oxygen delivery systems (DODS) that provide an oxygen 
      bolus only during inspiration have gained increasing use as they prolong oxygen 
      cylinder life (beside battery life). However, there is a lack of evidence if 
      different DODS and CF devices are equivalent. METHODS: Seventy hypoxemic COPD 
      patients (FEV(1) 32 +/- 9% predicted, PaO(2) 56+/-7 mmHg) on long-term oxygen therapy 
      were included in this prospective single-blinded, randomized cross-over trial. 
      Following an initial incremental shuttle walk test, patients performed 3 
      endurance shuttle walk tests (ESWT) at 85% of their maximum walking speed in 
      random order with: (A) CF (ESWT-CF), (B) a DODS based on liquid oxygen (ESWT-DL) 
      and (C) an DODS oxygen concentrator (ESWT-DC). The primary outcome was oxygen 
      saturation (SpO(2)) at ESWT isotime. Secondary outcomes were total ESWT duration, 
      heart rate (HR) and breathing frequency (BF) at isotime and dyspnea at 
      end-exercise. RESULTS: SpO(2) at ESWT isotime was not clinically different 
      between devices: 90 +/- 4% (CF), 89 +/- 5% (DL) and 90 +/- 5% (DC). However, 20% of the 
      patients showed a >/=4% lower oxygen desaturation while using a DODS device. 
      Secondary outcomes were similar under the three conditions. CONCLUSION: Oxygen 
      supplementation via DODS (based on liquid oxygen or as a concentrator) yielded 
      comparable physiological effects during standardized walking in stable hypoxemic 
      COPD patients like CF. However, 20% of patients showed a clinically relevant 
      lower oxygen saturation while using a DODS device. Therefore, we suggest 
      individual testing of oxygen saturation of DODS suitability.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Gloeckl, Rainer
AU  - Gloeckl R
AD  - Institute for Pulmonary Rehabilitation Research, Schoen Klinik Berchtesgadener 
      Land, Schoenau am Koenigssee, Germany; Department of Prevention, Rehabilitation 
      and Sports Medicine, Technical University of Munich, Munich, Germany. Electronic 
      address: rgloeckl@schoen-klinik.de.
FAU - Jarosch, Inga
AU  - Jarosch I
AD  - Institute for Pulmonary Rehabilitation Research, Schoen Klinik Berchtesgadener 
      Land, Schoenau am Koenigssee, Germany.
FAU - Schneeberger, Tessa
AU  - Schneeberger T
AD  - Institute for Pulmonary Rehabilitation Research, Schoen Klinik Berchtesgadener 
      Land, Schoenau am Koenigssee, Germany; Department of Pulmonary Rehabilitation, 
      Philipps-University of Marburg, German Center for Lung Research (DZL), Marburg, 
      Germany.
FAU - Fiedler, Claudia
AU  - Fiedler C
AD  - Department of Prevention, Rehabilitation and Sports Medicine, Technical 
      University of Munich, Munich, Germany.
FAU - Lausen, Melody
AU  - Lausen M
AD  - Department of Internal Medicine, Philipps University of Marburg, Marburg, 
      Germany.
FAU - Weingaertner, Julian
AU  - Weingaertner J
AD  - Department of Internal Medicine, Philipps University of Marburg, Marburg, 
      Germany.
FAU - Hitzl, Wolfgang
AU  - Hitzl W
AD  - Research Office (Biostatistics), Paracelsus Medical University, Salzburg, 
      Austria; Department of Ophthalmology and Optometry, Paracelsus Medical 
      University, Salzburg, Austria; Research Program Experimental Ophthalmology and 
      Glaucoma Research, Paracelsus Medical University, Salzburg, Austria.
FAU - Kenn, Klaus
AU  - Kenn K
AD  - Institute for Pulmonary Rehabilitation Research, Schoen Klinik Berchtesgadener 
      Land, Schoenau am Koenigssee, Germany; Department of Pulmonary Rehabilitation, 
      Philipps-University of Marburg, German Center for Lung Research (DZL), Marburg, 
      Germany.
FAU - Koczulla, Andreas Rembert
AU  - Koczulla AR
AD  - Institute for Pulmonary Rehabilitation Research, Schoen Klinik Berchtesgadener 
      Land, Schoenau am Koenigssee, Germany; Department of Pulmonary Rehabilitation, 
      Philipps-University of Marburg, German Center for Lung Research (DZL), Marburg, 
      Germany.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20190805
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Cross-Over Studies
MH  - Hypoxia/*therapy
MH  - Oxygen/*administration & dosage
MH  - Oxygen Inhalation Therapy/*methods
MH  - Prospective Studies
MH  - Pulmonary Disease, Chronic Obstructive/*therapy
OTO - NOTNLM
OT  - Endurance shuttle walk test
OT  - Exercise
OT  - Liquid oxygen
OT  - Long-term oxygen therapy
OT  - Oxygen concentrator
OT  - Pulmonary rehabilitation
EDAT- 2019/08/14 06:00
MHDA- 2020/08/25 06:00
CRDT- 2019/08/13 06:00
PHST- 2019/05/13 00:00 [received]
PHST- 2019/08/02 00:00 [revised]
PHST- 2019/08/05 00:00 [accepted]
PHST- 2019/08/14 06:00 [pubmed]
PHST- 2020/08/25 06:00 [medline]
PHST- 2019/08/13 06:00 [entrez]
AID - S0954-6111(19)30258-6 [pii]
AID - 10.1016/j.rmed.2019.08.001 [doi]
PST - ppublish
SO  - Respir Med. 2019 Sep;156:26-32. doi: 10.1016/j.rmed.2019.08.001. Epub 2019 Aug 5.