PMID- 31405350
OWN - NLM
STAT- MEDLINE
DCOM- 20200629
LR  - 20220414
IS  - 1938-9116 (Electronic)
IS  - 1538-5744 (Linking)
VI  - 53
IP  - 8
DP  - 2019 Nov
TI  - Predictors of Wound Healing Following Revascularization for Chronic 
      Limb-Threatening Ischemia.
PG  - 649-657
LID - 10.1177/1538574419868863 [doi]
AB  - OBJECTIVES: After surgical or endovascular revascularization, some ischemic 
      lesions will not heal, while some others will heal at a variable period of time 
      from the intervention, indicating a multifactorial interaction between local and 
      systematic "wound healing-promoting" factors. Our objective was to identify 
      predictors of wound healing following revascularization for chronic 
      limb-threatening ischemia (CLTI). METHODS: A literature review was performed to 
      identify published research concerning clinical, biochemical, and noninvasive 
      methods as predictors of wound healing time and wound-free period after surgical 
      and endovascular revascularization for CLTI. RESULTS: Our review indicated that 
      potential predictors included local wound factors, wound depth, patient's 
      comorbidities, medications, smoking and alcohol abuse, poor vessel runoff, and 
      direct versus indirect revascularization. Among the clinical biomarkers, 
      platelet-derived growth factor, transforming growth factor beta, basic fibroblast 
      growth factor, tumor necrosis factor alpha, interleukin (IL) 1, and IL-6 have been 
      proposed as potential predictors. Furthermore, the potential of noninvasive 
      microcirculation assessment to predict proper wound healing has been the topic of 
      extensive investigation. Among the novel methods, transcutaneous measurement of 
      oxygen partial pressure, skin perfusion pressure, oxygen-to-see method, 
      indocyanine green fluorescence imaging, and multispectral optoacoustic tomography 
      have shown promising results. CONCLUSIONS: The risk factor profile of an ischemic 
      lesion in the lower extremities with a delayed/failed healing response, following 
      a successful revascularization, is not fully clarified. Although many predictors 
      have been assessed so far, further research needs to be done to identify the 
      optimal clinical and biochemical indices and the noninvasive technique assessing 
      the microcirculation that is associated with complete wound healing.
FAU - Antonopoulos, Constantine N
AU  - Antonopoulos CN
AUID- ORCID: 0000-0003-0696-695X
AD  - Department of Vascular Surgery, "Attikon" University Hospital, Athens, Greece.
FAU - Lazaris, Andreas
AU  - Lazaris A
AD  - Department of Vascular Surgery, "Attikon" University Hospital, Athens, Greece.
FAU - Venermo, Maarit
AU  - Venermo M
AD  - Department of Vascular Surgery, Abdominal Center, University of Helsinki and 
      Helsinki University Hospital, Helsinki, Finland.
FAU - Geroulakos, George
AU  - Geroulakos G
AD  - Department of Vascular Surgery, "Attikon" University Hospital, Athens, Greece.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190812
PL  - United States
TA  - Vasc Endovascular Surg
JT  - Vascular and endovascular surgery
JID - 101136421
SB  - IM
MH  - Animals
MH  - Arteries/diagnostic imaging/metabolism/physiopathology/*surgery
MH  - Chronic Disease
MH  - *Endovascular Procedures/adverse effects
MH  - Humans
MH  - Ischemia/diagnostic imaging/metabolism/physiopathology/*surgery
MH  - Peripheral Arterial Disease/diagnostic 
      imaging/metabolism/physiopathology/*surgery
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
MH  - *Vascular Surgical Procedures/adverse effects
MH  - *Wound Healing
OTO - NOTNLM
OT  - biomarkers
OT  - chronic limb-threatening ischemia
OT  - revascularization
OT  - wound healing
EDAT- 2019/08/14 06:00
MHDA- 2020/07/01 06:00
CRDT- 2019/08/14 06:00
PHST- 2019/08/14 06:00 [pubmed]
PHST- 2020/07/01 06:00 [medline]
PHST- 2019/08/14 06:00 [entrez]
AID - 10.1177/1538574419868863 [doi]
PST - ppublish
SO  - Vasc Endovascular Surg. 2019 Nov;53(8):649-657. doi: 10.1177/1538574419868863. 
      Epub 2019 Aug 12.