PMID- 31407030
OWN - NLM
STAT- MEDLINE
DCOM- 20200324
LR  - 20211020
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 30
IP  - 1
DP  - 2020 Jan
TI  - Prevalence and prognostic value of late gadolinium enhancement on CMR in aortic 
      stenosis: meta-analysis.
PG  - 640-651
LID - 10.1007/s00330-019-06386-3 [doi]
AB  - OBJECTIVES: The aim of this study was to investigate the prevalence and 
      prognostic value of late gadolinium enhancement (LGE), as assessed by 
      cardiovascular magnetic resonance (CMR) imaging, in patients with aortic 
      stenosis. METHODS AND RESULTS: A systematic search of PubMed and EMBASE was 
      performed, and observational cohort studies that analysed the prevalence of LGE 
      and its relation to clinical outcomes in patients with aortic stenosis were 
      included. Odds ratios were used to measure an effect of the presence of LGE on 
      both all-cause and cardiovascular mortality. Nineteen studies were retrieved, 
      accounting for 2032 patients (mean age 69.8 years, mean follow-up 2.8 years). We 
      found that LGE is highly prevalent in aortic stenosis, affecting half of all 
      patients (49.6%), with a non-infarct pattern being the most frequent type 
      (63.6%). The estimated extent of focal fibrosis, expressed in % of LV mass, was 
      equal to 3.83 (95% CI [2.14, 5.52], p < 0.0001). The meta-analysis showed that 
      the presence of LGE was associated with increased all-cause (pooled OR [95% 
      CI] = 3.26 [1.72, 6.18], p = 0.0003) and cardiovascular mortality (pooled OR [95% 
      CI] = 2.89 [1.90, 4.38], p < 0.0001). CONCLUSIONS: LGE by CMR is highly prevalent 
      in aortic stenosis patients and exhibits a substantial value in all-cause and 
      cardiovascular mortality prediction. These results suggest a potential role of 
      LGE in aortic stenosis patient risk stratification. KEY POINTS: * Up to the half 
      of aortic stenosis patients are affected by myocardial focal fibrosis. * 
      Sixty-four percent of focal fibrosis detected by LGE-CMR is non-infarct type. * 
      The presence of focal fibrosis triples all-cause and cardiovascular mortality.
FAU - Balciunaite, Giedre
AU  - Balciunaite G
AUID- ORCID: 0000-0001-7447-3001
AD  - Clinic of Cardiovascular Diseases, Institute of Clinical Medicine, Vilnius 
      University Faculty of Medicine, Santariskiu st. 2, 08661, Vilnius, Lithuania. 
      dr.giedre.balciunaite@gmail.com.
FAU - Skorniakov, Viktor
AU  - Skorniakov V
AD  - Faculty of Mathematics and Informatics, Institute of Applied Mathematics, Vilnius 
      University, Naugarduko str. 24, LT-03225, Vilnius, Lithuania.
FAU - Rimkus, Arnas
AU  - Rimkus A
AD  - Clinic of Cardiovascular Diseases, Institute of Clinical Medicine, Vilnius 
      University Faculty of Medicine, Santariskiu st. 2, 08661, Vilnius, Lithuania.
FAU - Zaremba, Tomas
AU  - Zaremba T
AD  - Clinic of Cardiovascular Diseases, Institute of Clinical Medicine, Vilnius 
      University Faculty of Medicine, Santariskiu st. 2, 08661, Vilnius, Lithuania.
AD  - Aalborg University Hospital, Clinical Institute of Aalborg University, Hobrovej 
      18-22, 9100, Aalborg, Denmark.
FAU - Palionis, Darius
AU  - Palionis D
AD  - Department of Radiology, Nuclear Medicine and Medical Physics, Institute of 
      Biomedical Sciences, Vilnius University Faculty of Medicine, Santariskiu st. 2, 
      08661, Vilnius, Lithuania.
FAU - Valeviciene, Nomeda
AU  - Valeviciene N
AD  - Department of Radiology, Nuclear Medicine and Medical Physics, Institute of 
      Biomedical Sciences, Vilnius University Faculty of Medicine, Santariskiu st. 2, 
      08661, Vilnius, Lithuania.
FAU - Aidietis, Audrius
AU  - Aidietis A
AD  - Clinic of Cardiovascular Diseases, Institute of Clinical Medicine, Vilnius 
      University Faculty of Medicine, Santariskiu st. 2, 08661, Vilnius, Lithuania.
FAU - Serpytis, Pranas
AU  - Serpytis P
AD  - Clinic of Cardiovascular Diseases, Institute of Clinical Medicine, Vilnius 
      University Faculty of Medicine, Santariskiu st. 2, 08661, Vilnius, Lithuania.
FAU - Rucinskas, Kestutis
AU  - Rucinskas K
AD  - Clinic of Cardiovascular Diseases, Institute of Clinical Medicine, Vilnius 
      University Faculty of Medicine, Santariskiu st. 2, 08661, Vilnius, Lithuania.
FAU - Sogaard, Peter
AU  - Sogaard P
AD  - Clinic of Cardiovascular Diseases, Institute of Clinical Medicine, Vilnius 
      University Faculty of Medicine, Santariskiu st. 2, 08661, Vilnius, Lithuania.
AD  - Aalborg University Hospital, Clinical Institute of Aalborg University, Hobrovej 
      18-22, 9100, Aalborg, Denmark.
FAU - Glaveckaite, Sigita
AU  - Glaveckaite S
AD  - Clinic of Cardiovascular Diseases, Institute of Clinical Medicine, Vilnius 
      University Faculty of Medicine, Santariskiu st. 2, 08661, Vilnius, Lithuania.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20190812
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
EIN - Eur Radiol. 2020 Sep;30(9):5222. PMID: 32291500
MH  - Aged
MH  - Aorta/diagnostic imaging
MH  - Aortic Valve Stenosis/*diagnostic imaging/pathology
MH  - Cohort Studies
MH  - Contrast Media/*pharmacokinetics
MH  - Female
MH  - Gadolinium/*pharmacokinetics
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Observational Studies as Topic
MH  - Prevalence
MH  - Prognosis
OTO - NOTNLM
OT  - Aortic stenosis
OT  - Fibrosis
OT  - Magnetic resonance imaging
OT  - Meta-analysis
OT  - Prognosis
EDAT- 2019/08/14 06:00
MHDA- 2020/03/25 06:00
CRDT- 2019/08/14 06:00
PHST- 2019/04/12 00:00 [received]
PHST- 2019/07/22 00:00 [accepted]
PHST- 2019/07/08 00:00 [revised]
PHST- 2019/08/14 06:00 [pubmed]
PHST- 2020/03/25 06:00 [medline]
PHST- 2019/08/14 06:00 [entrez]
AID - 10.1007/s00330-019-06386-3 [pii]
AID - 10.1007/s00330-019-06386-3 [doi]
PST - ppublish
SO  - Eur Radiol. 2020 Jan;30(1):640-651. doi: 10.1007/s00330-019-06386-3. Epub 2019 
      Aug 12.