PMID- 31408207
OWN - NLM
STAT- MEDLINE
DCOM- 20200115
LR  - 20200115
IS  - 1556-4029 (Electronic)
IS  - 0022-1198 (Linking)
VI  - 65
IP  - 1
DP  - 2020 Jan
TI  - Correlations Among the HLA-DQB1 Alleles and Suicidal Behavior.
PG  - 166-169
LID - 10.1111/1556-4029.14166 [doi]
AB  - Suicide is a worldwide health problem with multiple causes, including genetic 
      factors. The major histocompatibility complex (MHC) is represented by an assembly 
      of gene encoding the human leukocyte antigen (HLA). The purpose of our study was 
      to determine associations between the HLA profiles and predisposition for 
      suicidal behavior. We harvested blood samples from persons with history of 
      suicidal attempts (case group) and persons never exhibiting such behavior 
      (control group). The DNA was extracted and amplified via polymerase chain 
      reaction (PCR) to determine the HLA-DQB1 profiles. Statistical data processing 
      was performed with the Epi Info program. We found that the presence of the 
      HLA-DQB1*02 allele increases the risk of suicidal behavior, while HLA-DQB1*05 
      alleviates such risk. The genotype that presented the most increased risk for 
      suicidal behavior was found to be HLA-DQB1*02/HLA-DQB1*03. Our study has 
      demonstrated the presence of several associations between HLA profiles and 
      suicidal behavior.
CI  - (c) 2019 American Academy of Forensic Sciences.
FAU - Matei, Horea V
AU  - Matei HV
AD  - Department of Cell and Molecular Biology, 'Iuliu Hatieganu' University of 
      Medicine and Pharmacy, 6 Pasteur Street, 400 349, Cluj-Napoca, Romania.
AD  - Legal Medicine Institute Cluj-Napoca, 3-5 Clinicilor Street, 400 006, 
      Cluj-Napoca, Romania.
FAU - Vica, Mihaela L
AU  - Vica ML
AUID- ORCID: 0000-0003-0811-0821
AD  - Department of Cell and Molecular Biology, 'Iuliu Hatieganu' University of 
      Medicine and Pharmacy, 6 Pasteur Street, 400 349, Cluj-Napoca, Romania.
FAU - Ciuca, Irina
AU  - Ciuca I
AD  - Department of Cell and Molecular Biology, 'Iuliu Hatieganu' University of 
      Medicine and Pharmacy, 6 Pasteur Street, 400 349, Cluj-Napoca, Romania.
FAU - Coman, Horia G
AU  - Coman HG
AD  - Department of Medical Psychology, 'Iuliu Hatieganu' University of Medicine and 
      Pharmacy, 43 Victor Babes Street, 400 012, Cluj-Napoca, Romania.
FAU - Nicula, Gheorghe Z
AU  - Nicula GZ
AD  - Department of Cell and Molecular Biology, 'Iuliu Hatieganu' University of 
      Medicine and Pharmacy, 6 Pasteur Street, 400 349, Cluj-Napoca, Romania.
FAU - Siserman, Costel V
AU  - Siserman CV
AD  - Legal Medicine Institute Cluj-Napoca, 3-5 Clinicilor Street, 400 006, 
      Cluj-Napoca, Romania.
AD  - Department of Legal Medicine, 'Iuliu Hatieganu' University of Medicine and 
      Pharmacy, 3-5 Clinicilor Street, 400 006, Cluj-Napoca, Romania.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20190813
PL  - United States
TA  - J Forensic Sci
JT  - Journal of forensic sciences
JID - 0375370
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-DQ beta-Chains/*genetics
MH  - Humans
MH  - Male
MH  - Polymerase Chain Reaction
MH  - *Suicide, Attempted
OTO - NOTNLM
OT  - DNA typing
OT  - DQB1
OT  - forensic science
OT  - genotype
OT  - human leukocyte antigen
OT  - polymerase chain reaction
OT  - suicide
EDAT- 2019/08/14 06:00
MHDA- 2020/01/16 06:00
CRDT- 2019/08/14 06:00
PHST- 2019/04/23 00:00 [received]
PHST- 2019/06/26 00:00 [revised]
PHST- 2019/07/26 00:00 [accepted]
PHST- 2019/08/14 06:00 [pubmed]
PHST- 2020/01/16 06:00 [medline]
PHST- 2019/08/14 06:00 [entrez]
AID - 10.1111/1556-4029.14166 [doi]
PST - ppublish
SO  - J Forensic Sci. 2020 Jan;65(1):166-169. doi: 10.1111/1556-4029.14166. Epub 2019 
      Aug 13.