PMID- 31408434
OWN - NLM
STAT- MEDLINE
DCOM- 20191210
LR  - 20221005
IS  - 2191-0308 (Electronic)
IS  - 0048-7554 (Print)
IS  - 0048-7554 (Linking)
VI  - 34
IP  - 3
DP  - 2019 Sep 25
TI  - Application of metabolomics to characterize environmental pollutant toxicity and 
      disease risks.
PG  - 251-259
LID - 10.1515/reveh-2019-0030 [doi]
AB  - The increased incidence of non-communicable human diseases may be attributed, at 
      least partially, to exposures to toxic chemicals such as persistent organic 
      pollutants (POPs), air pollutants and heavy metals. Given the high mortality and 
      morbidity of pollutant exposure associated diseases, a better understanding of 
      the related mechanisms of toxicity and impacts on the endogenous host metabolism 
      are needed. The metabolome represents the collection of the intermediates and end 
      products of cellular processes, and is the most proximal reporter of the body's 
      response to environmental exposures and pathological processes. Metabolomics is a 
      powerful tool for studying how organisms interact with their environment and how 
      these interactions shape diseases related to pollutant exposure. This mini review 
      discusses potential biological mechanisms that link pollutant exposure to 
      metabolic disturbances and chronic human diseases, with a focus on recent studies 
      that demonstrate the application of metabolomics as a tool to elucidate 
      biochemical modes of actions of various environmental pollutants. In addition, 
      classes of metabolites that have been shown to be modulated by multiple 
      environmental pollutants will be discussed with an emphasis on their use as 
      potential early biomarkers of disease risks. Taken together, metabolomics is a 
      useful and versatile tool for characterizing the disease risks and mechanisms 
      associated with various environmental pollutants.
FAU - Deng, Pan
AU  - Deng P
AD  - Superfund Research Center, University of Kentucky, Lexington, KY, USA.
AD  - Department of Animal and Food Sciences, College of Agriculture, Food and 
      Environment, University of Kentucky, Lexington, KY, USA.
FAU - Li, Xusheng
AU  - Li X
AD  - Superfund Research Center, University of Kentucky, Lexington, KY, USA.
AD  - Department of Food Science and Engineering, Institute of Food Safety and 
      Nutrition, College of Science and Engineering, Jinan University, Guangzhou, PR 
      China.
FAU - Petriello, Michael C
AU  - Petriello MC
AD  - Superfund Research Center, University of Kentucky, Lexington, KY, USA.
AD  - Division of Cardiovascular Medicine, College of Medicine, University of Kentucky, 
      and Lexington Veterans Affairs Medical Center, Lexington, KY, USA.
FAU - Wang, Chunyan
AU  - Wang C
AD  - Superfund Research Center, University of Kentucky, Lexington, KY, USA.
AD  - Department of Animal and Food Sciences, College of Agriculture, Food and 
      Environment, University of Kentucky, Lexington, KY, USA.
FAU - Morris, Andrew J
AU  - Morris AJ
AD  - Superfund Research Center, University of Kentucky, Lexington, KY, USA.
AD  - Division of Cardiovascular Medicine, College of Medicine, University of Kentucky, 
      and Lexington Veterans Affairs Medical Center, Lexington, KY, USA.
FAU - Hennig, Bernhard
AU  - Hennig B
AD  - Superfund Research Center, University of Kentucky, Lexington, KY, USA.
AD  - Department of Animal and Food Sciences, College of Agriculture, Food and 
      Environment, University of Kentucky, Lexington, KY, USA.
LA  - eng
GR  - K99 ES028734/ES/NIEHS NIH HHS/United States
GR  - P30 ES026529/ES/NIEHS NIH HHS/United States
GR  - P42 ES007380/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Rev Environ Health
JT  - Reviews on environmental health
JID - 0425754
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Environmental Exposure/*adverse effects
MH  - Environmental Pollutants/*toxicity
MH  - Humans
MH  - Metabolomics/*methods
MH  - Noncommunicable Diseases/*epidemiology
PMC - PMC6915040
MID - NIHMS1062296
OTO - NOTNLM
OT  - POP
OT  - disease
OT  - heavy metal
OT  - metabolomics
OT  - pollutant
OT  - toxicity
COIS- Financial interests The authors declare they have no actual or potential 
      competing conflict of financial interest relevant to this work.
EDAT- 2019/08/14 06:00
MHDA- 2019/12/18 06:00
PMCR- 2020/09/25
CRDT- 2019/08/14 06:00
PHST- 2019/04/22 00:00 [received]
PHST- 2019/07/23 00:00 [accepted]
PHST- 2019/08/14 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/08/14 06:00 [entrez]
PHST- 2020/09/25 00:00 [pmc-release]
AID - reveh-2019-0030 [pii]
AID - 10.1515/reveh-2019-0030 [doi]
PST - ppublish
SO  - Rev Environ Health. 2019 Sep 25;34(3):251-259. doi: 10.1515/reveh-2019-0030.