PMID- 31409832
OWN - NLM
STAT- MEDLINE
DCOM- 20201118
LR  - 20210110
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Aug 13
TI  - TNF-alpha promoter polymorphisms (G-238A and G-308A) are associated with 
      susceptibility to Systemic Lupus Erythematosus (SLE) and P. falciparum malaria: a 
      study in malaria endemic area.
PG  - 11752
LID - 10.1038/s41598-019-48182-5 [doi]
LID - 11752
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine associated with 
      autoimmune and infectious diseases. Importance of TNF-alpha in P. falciparum malaria 
      and systemic lupus erythematosus (SLE) have been demonstrated. However, 
      association of functional promoter variants with SLE and malaria is lacking in 
      malaria endemic population. A total of 204 female SLE patients and 224 age and 
      sex matched healthy controls were enrolled in the study. Three hundred fourteen 
      P. falciparum infected patients with different clinical phenotypes were included. 
      TNF-alpha polymorphisms (G-238A & G-308A) were genotyped by PCR-RFLP. Plasma levels 
      of TNF-alpha was quantified by ELISA. Heterozygous mutants and minor alleles of TNF-alpha 
      (G-238A and G-308A) polymorphisms were significantly higher in SLE patients 
      compared to healthy controls and associated with development of lupus nephritis. 
      In addition, both promoter variants were associated with severe P. 
      falciparum malaria. SLE patients demonstrated higher levels of plasma TNF-alpha 
      compared to healthy controls. TNF-alpha (G-238A and G-308A) variants were associated 
      with higher plasma TNF-alpha. In conclusion, TNF-alpha (G-238A & G-308A) variants are 
      associated with higher plasma TNF-alpha levels in SLE patients residing in malaria 
      endemic areas and could be a contributing factor in the development of SLE and 
      susceptibility to severe P. falciparum malaria.
FAU - Mahto, Harishankar
AU  - Mahto H
AD  - Department of Bioscience and Bioinformatics, Khallikote University, GMax 
      Building, Konisi, Berhampur, 761008, Odisha, India.
AD  - Centre for Life Sciences, Central University of Jharkhand, Brambe, Ranchi, 
      835205, Jharkhand, India.
FAU - Tripathy, Rina
AU  - Tripathy R
AD  - Department of Biochemistry, S.C.B. Medical College, Cuttack, 753007, Odisha, 
      India.
FAU - Meher, Biswa Ranjan
AU  - Meher BR
AD  - Computational Biology and Bioinformatics Laboratory, Department of Botany, 
      Berhampur University, Berhampur, Odisha, 760007, India.
FAU - Prusty, Birendra K
AU  - Prusty BK
AD  - Infectious Disease Biology Group, Institute of Life Sciences, Bhubaneswar, 
      Odisha, India.
FAU - Sharma, Meenakshi
AU  - Sharma M
AD  - Centre for Life Sciences, Central University of Jharkhand, Brambe, Ranchi, 
      835205, Jharkhand, India.
FAU - Deogharia, Divya
AU  - Deogharia D
AD  - Centre for Life Sciences, Central University of Jharkhand, Brambe, Ranchi, 
      835205, Jharkhand, India.
FAU - Saha, Anjana Kumari
AU  - Saha AK
AD  - Centre for Life Sciences, Central University of Jharkhand, Brambe, Ranchi, 
      835205, Jharkhand, India.
FAU - Panda, Aditya K
AU  - Panda AK
AD  - Department of Bioscience and Bioinformatics, Khallikote University, GMax 
      Building, Konisi, Berhampur, 761008, Odisha, India. adityarmrc@gmail.com.
AD  - Centre for Life Sciences, Central University of Jharkhand, Brambe, Ranchi, 
      835205, Jharkhand, India. adityarmrc@gmail.com.
FAU - Das, Bidyut K
AU  - Das BK
AD  - Department of Medicine, S.C.B. Medical College, Cuttack, 753007, Odisha, India. 
      bidyutdas@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190813
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Endemic Diseases
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*genetics
MH  - Malaria, Falciparum/epidemiology/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - *Promoter Regions, Genetic
MH  - Tumor Necrosis Factor-alpha/*genetics
PMC - PMC6692415
COIS- The authors declare no competing interests.
EDAT- 2019/08/15 06:00
MHDA- 2020/11/20 06:00
PMCR- 2019/08/13
CRDT- 2019/08/15 06:00
PHST- 2018/01/26 00:00 [received]
PHST- 2019/07/26 00:00 [accepted]
PHST- 2019/08/15 06:00 [entrez]
PHST- 2019/08/15 06:00 [pubmed]
PHST- 2020/11/20 06:00 [medline]
PHST- 2019/08/13 00:00 [pmc-release]
AID - 10.1038/s41598-019-48182-5 [pii]
AID - 48182 [pii]
AID - 10.1038/s41598-019-48182-5 [doi]
PST - epublish
SO  - Sci Rep. 2019 Aug 13;9(1):11752. doi: 10.1038/s41598-019-48182-5.