PMID- 31409962
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220410
IS  - 1177-5467 (Print)
IS  - 1177-5483 (Electronic)
IS  - 1177-5467 (Linking)
VI  - 13
DP  - 2019
TI  - 360 degrees  ab-interno Schlemm's canal viscodilation in primary open-angle glaucoma.
PG  - 1235-1246
LID - 10.2147/OPTH.S203917 [doi]
AB  - Purpose: To evaluate the safety and effectiveness of ab-interno 
      microcatheterization and 360 degrees  viscodilation of Schlemm's canal (SC) using the 
      VISCO360((R)) Viscosurgical System in treatment of primary open angle glaucoma 
      (POAG). Setting: Surgical center (Augencentrum Koln, Koln, Germany). Design: 
      Retrospective analysis of 106 eyes from 71 consecutive patients. Methods: 
      Ab-interno canal viscodilation (VISCO360((R))) with or without cataract extraction 
      was performed in two groups of patients with mild-moderate POAG: Group 1 had a 
      baseline intraocular pressure (IOP) >/=18 mmHg (n=72 eyes) and Group 2 had a 
      baseline IOP <18 mmHg (n=34 eyes). IOP without washout was measured and number of 
      IOP-lowering medications were documented at all visits. Effectiveness was 
      determined by reduction in IOP and reduction in the number of IOP-lowering 
      medications at 12+/-3 months from baseline. Safety was determined by the rate of 
      adverse events (AEs) and secondary surgical interventions (SSI). Results: In 
      Group 1, all eyes available at 12+/-3 months (n=72), had a 41.0% reduction in mean 
      IOP (from 24.6+/-7.1 mmHg to 14.6+/-2.8 mmHg), 87% (n=62) of which showed an IOP 
      reduction of >/=20% with no increase in IOP-lowering medications. In Group 2, all 
      eyes (n=34) maintained their baseline IOP at all postoperative visits. In both 
      groups, a significant decrease (>89%) in mean number of IOP-lowering medications 
      was seen at 12 months with 86% of eyes completely off medication with no increase 
      in IOP. The most common AE seen was hyphema (13%) and no eye required SSI during 
      the study period. Conclusion: Ab-interno SC viscodilation (VISCO360) is safe and 
      effective in lowering IOP and reducing hypotensive medications in patients with 
      OAG.
FAU - Ondrejka, Simon
AU  - Ondrejka S
AD  - Augencentrum Koln , Koln, Germany.
FAU - Korber, Norbert
AU  - Korber N
AD  - Augencentrum Koln , Koln, Germany.
AD  - Eye Clinic, University Eye Hospital, Padova, Italy.
LA  - eng
PT  - Journal Article
DEP - 20190715
PL  - New Zealand
TA  - Clin Ophthalmol
JT  - Clinical ophthalmology (Auckland, N.Z.)
JID - 101321512
PMC - PMC6645607
OTO - NOTNLM
OT  - 360-degree trabeculotomy
OT  - POAG
OT  - VISCO360(R)
OT  - blebless, MIGS
OT  - canaloplasty
COIS- The authors have no commercial or proprietary interest in any of the materials 
      discussed in this article. The authors report no conflicts of interest in this 
      work.
EDAT- 2019/08/15 06:00
MHDA- 2019/08/15 06:01
PMCR- 2019/07/15
CRDT- 2019/08/15 06:00
PHST- 2019/02/02 00:00 [received]
PHST- 2019/05/09 00:00 [accepted]
PHST- 2019/08/15 06:00 [entrez]
PHST- 2019/08/15 06:00 [pubmed]
PHST- 2019/08/15 06:01 [medline]
PHST- 2019/07/15 00:00 [pmc-release]
AID - 203917 [pii]
AID - 10.2147/OPTH.S203917 [doi]
PST - epublish
SO  - Clin Ophthalmol. 2019 Jul 15;13:1235-1246. doi: 10.2147/OPTH.S203917. eCollection 
      2019.