PMID- 31410041
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 12
DP  - 2019
TI  - Cross-sectional and longitudinal assessments of risk factors associated with 
      hypertension and moderately increased albuminuria comorbidity in patients with 
      type 2 diabetes: a 9-year open cohort study.
PG  - 1123-1139
LID - 10.2147/DMSO.S189726 [doi]
AB  - BACKGROUND: Moderately increased albuminuria (MIA) is strongly associated with 
      hypertension (HTN) in patients with type 2 diabetic mellitus (T2DM). However, the 
      association between risk factors and coexisting HTN and MIA remains unassessed. 
      OBJECTIVES: This study aimed to determine both cross-sectional and longitudinal 
      associations of risk factors with HTN and MIA comorbidity in patients with T2DM. 
      METHODS: A total of 1,600 patients with T2DM were examined at baseline and 
      longitudinal data were obtained from 1,337 T2DM patients with at least 2 
      follow-up visits to assess the presence of HTN alone (yes/no), MIA alone (yes/no) 
      and the coexistence of both (yes/no) in a 9-year open cohort study between 2004 
      and 2013. Bivariate mixed-effects logistic regression with a Bayesian approach 
      was employed to evaluate associations of risk factors with HTN and MIA‎ 
      comorbidity in the longitudinal assessment. RESULTS: After adjustment for age and 
      BMI, patients with uncontrolled plasma glucose, as a combined index of the 
      glucose profile, were more likely to have HTN [odds ratio (OR): 1.73 with 95% 
      Bayesian credible intervals (BCI) 1.29-2.20] and MIA [OR: 1.34 (‎95% BCI 
      1.13-1.62)]. The risks of having HTN and MIA were increased by a one-year raise 
      in diabetes duration [with 0.89 (95% BCI 0.84-0.96) and 0.81 (95% BCI 0.73-0.92) 
      ORs, respectively] and a one-unit increase in non-high-density 
      lipoprotein-cholesterol (Non-HDL-C) [with 1.30 (95% BCI 1.23-1.34) and 1.24 (95% 
      BCI 1.14-1.33) ORs, respectively]. CONCLUSIONS: T2DM patients with HTN,‎ MIA, and 
      the coexistence of both had uncontrolled plasma glucose, significantly higher 
      Non-HDL-C, and shorter diabetes duration than the other T2DM patients. Duration 
      of diabetes and uncontrolled plasma glucose index showed the stronger effects on 
      HTN and MIA comorbidity than on each condition separately.
FAU - Hadi Alijanvand, Moluk
AU  - Hadi Alijanvand M
AD  - Department of Epidemiology and Biostatistics, School of Health, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
AD  - Isfahan Endocrine and Metabolism Research Centre, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
AD  - Student Research Center, School of Health, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Aminorroaya, Ashraf
AU  - Aminorroaya A
AD  - Isfahan Endocrine and Metabolism Research Centre, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Kazemi, Iraj
AU  - Kazemi I
AD  - Department of Statistics, College of Science, University of Isfahan, Isfahan, 
      Iran.
FAU - Aminorroaya Yamini, Sima
AU  - Aminorroaya Yamini S
AD  - Department of Engineering and Mathematics, Sheffiled Hallam University, 
      Sheffield, UK.
FAU - Janghorbani, Mohsen
AU  - Janghorbani M
AD  - Department of Epidemiology and Biostatistics, School of Health, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
AD  - Isfahan Endocrine and Metabolism Research Centre, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Amini, Masoud
AU  - Amini M
AD  - Isfahan Endocrine and Metabolism Research Centre, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Mansourian, Marjan
AU  - Mansourian M
AD  - Department of Epidemiology and Biostatistics, School of Health, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
AD  - Isfahan Endocrine and Metabolism Research Centre, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
LA  - eng
PT  - Journal Article
DEP - 20190715
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC6646050
OTO - NOTNLM
OT  - comorbidity
OT  - hypertension
OT  - microalbuminuria
OT  - moderately increased albuminuria
OT  - risk factor
OT  - type 2 diabetes
COIS- The authors report no conflicts of interest in regard to this work.
EDAT- 2019/08/15 06:00
MHDA- 2019/08/15 06:01
PMCR- 2019/07/15
CRDT- 2019/08/15 06:00
PHST- 2018/10/20 00:00 [received]
PHST- 2019/05/21 00:00 [accepted]
PHST- 2019/08/15 06:00 [entrez]
PHST- 2019/08/15 06:00 [pubmed]
PHST- 2019/08/15 06:01 [medline]
PHST- 2019/07/15 00:00 [pmc-release]
AID - 189726 [pii]
AID - 10.2147/DMSO.S189726 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2019 Jul 15;12:1123-1139. doi: 10.2147/DMSO.S189726. 
      eCollection 2019.