PMID- 31410734
OWN - NLM
STAT- MEDLINE
DCOM- 20220216
LR  - 20240130
IS  - 1532-6551 (Electronic)
IS  - 1071-3581 (Linking)
VI  - 28
IP  - 4
DP  - 2021 Aug
TI  - Diastolic dyssynchrony assessment by gated myocardial perfusion-SPECT in subjects 
      who underwent cardiac resynchronization therapy.
PG  - 1413-1421
LID - 10.1007/s12350-019-01845-2 [doi]
AB  - BACKGROUND: Left ventricular diastolic dyssynchrony (LVDD) can be assessed by 
      gated myocardial perfusion single-photon emission computed tomography 
      (GMP-SPECT). LVDD is an area of interest in subjects who underwent cardiac 
      resynchronization therapy (CRT). The aim of this post hoc analysis was to assess 
      the role of LVDD in subjects with CRT who were followed up at 6-month period. 
      MATERIAL & METHODS: Left ventricular diastolic dyssynchrony was assessed by 
      GMP-SPECT at baseline and after CRT procedure in 160 subjects from 10 different 
      cardiological centers. CRT procedure was performed as per current guidelines. 
      Outcomes were defined as improvement in >/=1 New York Heart Association (NYHA) 
      class, left ventricular ejection fraction (LVEF) by 5%, and reduction in 
      end-systolic volume (ESV) by 15% and 5% points in Minnesota Living with Heart 
      Failure Questionnaire. LVDD was defined as diastolic phase standard deviation >/=40 
      +/- 14 degrees . RESULTS: Improvement in NYHA functional class occurred in 105 (65.6%), 
      LVEF in 74 (46.3%), decrease in ESV in 86 (53.8%), and Minnesota score in 85 
      (53.1%) cases. Baseline LV diastolic standard deviation was 53.53 degrees  +/- 20.85 and at 
      follow-up 40.44 degrees  +/- 26.1283; (P < 0.001). LVDD was not associated with improvement 
      in clinical outcomes at follow-up. CONCLUSION: CRT improves both systolic and 
      diastolic dyssynchrony values at 6-month follow-up. LVDD at baseline is 
      correlated with cardiac functionality at follow-up, but not with overall 
      favorable clinical outcomes.
CI  - (c) 2019. American Society of Nuclear Cardiology.
FAU - Alexanderson-Rosas, Erick
AU  - Alexanderson-Rosas E
AD  - Department of Nuclear Cardiology, National Institute of Cardiology Ignacio 
      Chavez, Juan Badiano N masculine 1, Colonia Seccion XVI, Tlalpan, P.C. 14080, Mexico City, 
      Mexico. alexandersonerick@gmail.com.
AD  - Department of Physiology, Faculty of Medicine, National Autonomous University of 
      Mexico, Mexico City, Mexico. alexandersonerick@gmail.com.
FAU - Espinola-Zavaleta, Nilda
AU  - Espinola-Zavaleta N
AD  - Department of Nuclear Cardiology, National Institute of Cardiology Ignacio 
      Chavez, Juan Badiano N masculine 1, Colonia Seccion XVI, Tlalpan, P.C. 14080, Mexico City, 
      Mexico.
FAU - Garcia, Ernest V
AU  - Garcia EV
AD  - Emory University, Atlanta, GA, USA.
FAU - Peix, Amalia
AU  - Peix A
AD  - Nuclear Medicine Department, Institute of Cardiology, La Habana, Cuba.
FAU - Massardo, Teresa
AU  - Massardo T
AD  - Hospital Clinico Universidad de Chile, Santiago, Chile.
FAU - Pabon, Luz M
AU  - Pabon LM
AD  - Fundacion Valle del Lili, Cali, Colombia.
FAU - Antonio-Villa, Neftali Eduardo
AU  - Antonio-Villa NE
AD  - Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico City, 
      Mexico.
FAU - Carvajal-Juarez, Isabel
AU  - Carvajal-Juarez I
AD  - Department of Nuclear Cardiology, National Institute of Cardiology Ignacio 
      Chavez, Juan Badiano N masculine 1, Colonia Seccion XVI, Tlalpan, P.C. 14080, Mexico City, 
      Mexico.
FAU - Mesquita, Claudio T
AU  - Mesquita CT
AD  - Hospital Universitario Antonio Pedro, Niteroi, Brazil.
FAU - Jimenez-Heffernan, Amelia
AU  - Jimenez-Heffernan A
AD  - Hospital Juan Ramon Jimenez, Huelva, Spain.
FAU - Patel, Chetan
AU  - Patel C
AD  - All India Institute of Medical Sciences, New Delhi, India.
FAU - Karthikeyan, Ganesan
AU  - Karthikeyan G
AD  - All India Institute of Medical Sciences, New Delhi, India.
FAU - Kumar, Alka
AU  - Kumar A
AD  - Dr. B L Kapur Memorial Hospital, New Delhi, India.
FAU - Butt, Sadaf
AU  - Butt S
AD  - Oncology and Radiotherapy Institute (NORI), Islamabad, Pakistan.
FAU - Kalaivani, Mani
AU  - Kalaivani M
AD  - All India Institute of Medical Sciences, New Delhi, India.
FAU - Marin, Victor
AU  - Marin V
AD  - Fundacion Cardioinfantil, Bogota, Colombia.
FAU - Morozova, Olga
AU  - Morozova O
AD  - Nuclear Medicine and Diagnostic Imaging Section, International Atomic Energy 
      Agency, Vienna, Austria.
FAU - Paez, Diana
AU  - Paez D
AD  - Nuclear Medicine and Diagnostic Imaging Section, International Atomic Energy 
      Agency, Vienna, Austria.
LA  - eng
PT  - Journal Article
DEP - 20190813
PL  - United States
TA  - J Nucl Cardiol
JT  - Journal of nuclear cardiology : official publication of the American Society of 
      Nuclear Cardiology
JID - 9423534
SB  - IM
MH  - Aged
MH  - *Cardiac Resynchronization Therapy
MH  - *Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography
MH  - Diastole
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Myocardial Perfusion Imaging
MH  - Prospective Studies
MH  - Stroke Volume
MH  - Ventricular Dysfunction, Left/*diagnostic imaging/therapy
OTO - NOTNLM
OT  - Diastolic dyssynchrony
OT  - SPECT
OT  - nuclear medicine
OT  - resynchronization therapy
EDAT- 2019/08/15 06:00
MHDA- 2022/02/17 06:00
CRDT- 2019/08/15 06:00
PHST- 2019/06/18 00:00 [received]
PHST- 2019/07/23 00:00 [accepted]
PHST- 2019/08/15 06:00 [pubmed]
PHST- 2022/02/17 06:00 [medline]
PHST- 2019/08/15 06:00 [entrez]
AID - S1071-3581(23)00955-8 [pii]
AID - 10.1007/s12350-019-01845-2 [doi]
PST - ppublish
SO  - J Nucl Cardiol. 2021 Aug;28(4):1413-1421. doi: 10.1007/s12350-019-01845-2. Epub 
      2019 Aug 13.