PMID- 31411500
OWN - NLM
STAT- MEDLINE
DCOM- 20200908
LR  - 20200908
IS  - 1557-8682 (Electronic)
IS  - 1527-0297 (Linking)
VI  - 20
IP  - 3
DP  - 2019 Sep
TI  - Effect of Acute Altitude Exposure on Serum Markers of Platelet Activation.
PG  - 318-321
LID - 10.1089/ham.2018.0112 [doi]
AB  - Background: Platelets are the key factor in primary hemostasis. It has been shown 
      that chronic altitude exposure increases platelets' aggregability. Nevertheless, 
      data about acute effects and the underlying mechanisms are sparse. Methods: 
      Sixteen healthy volunteers were examined in our hospital (519 m alt.) and 30 
      minutes after arrival in the environmental research station on the Zugspitze 
      Mountain (2656 m alt.). Serum levels of soluble p-selectin were examined to 
      elucidate platelet activation. In addition, serum levels of chromogranin A (CGA) 
      as a measure of adrenergic activation, endothelin 1 (ET-1) representing pulmonary 
      vascular tone and monocyte chemoattractant protein-1 (MCP-1) as a measure of 
      inflammatory response were examined. Results: Acute altitude exposure induced a 
      significant increase of p-selectin (116 +/- 4.8 pg/mL vs. 132 +/- 6.2 pg/mL; 
      p < 0.01). Whereas MCP-1 was significantly lowered (538 +/- 50.6 pg/mL to 
      470 +/- 41.1 pg/mL; p = 0.02) and CGA was not altered significantly 
      (88 +/- 47.4 ng/mL vs. 79 +/- 44 ng/mL; p = 0.22), ET1 was increased significantly 
      from 0.8 +/- 0.07 pg/mL to 1.15 +/- 0.09 pg/mL (p < 0.01). Conclusion: Our study 
      could demonstrate relevant platelet activation that was accompanied by a 44% 
      increase of ET-1. This activation might obtain clinical relevance in patients 
      with pre-existing cardiovascular disease as a trigger for acute events.
FAU - Lackermair, Korbinian
AU  - Lackermair K
AD  - Department of Medicine I, University Hospital Munich, Ludwig Maximilians 
      University, Munich, Germany.
FAU - Schuhmann, Christoph G
AU  - Schuhmann CG
AD  - Department of Medicine I, University Hospital Munich, Ludwig Maximilians 
      University, Munich, Germany.
FAU - Mertsch, Pontus
AU  - Mertsch P
AD  - Department of Medicine V, University Hospital Munich, Ludwig Maximilians 
      University, Munich, Germany.
FAU - Gotschke, Jeremias
AU  - Gotschke J
AD  - Department of Medicine V, University Hospital Munich, Ludwig Maximilians 
      University, Munich, Germany.
AD  - German Center for Lung Research (DZL), Comprehensive Pneumology Center (CPC-M), 
      Munich, Germany.
FAU - Milger, Katrin
AU  - Milger K
AD  - Department of Medicine V, University Hospital Munich, Ludwig Maximilians 
      University, Munich, Germany.
AD  - German Center for Lung Research (DZL), Comprehensive Pneumology Center (CPC-M), 
      Munich, Germany.
FAU - Brunner, Stefan
AU  - Brunner S
AD  - Department of Medicine I, University Hospital Munich, Ludwig Maximilians 
      University, Munich, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190814
PL  - United States
TA  - High Alt Med Biol
JT  - High altitude medicine & biology
JID - 100901183
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chromogranin A)
RN  - 0 (Endothelin-1)
RN  - 0 (P-Selectin)
RN  - 0 (SELP protein, human)
SB  - IM
MH  - Adult
MH  - *Altitude
MH  - Biomarkers/blood
MH  - Chemokine CCL2/blood
MH  - Chromogranin A/blood
MH  - Endothelin-1/blood
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - P-Selectin/blood
MH  - *Platelet Activation
OTO - NOTNLM
OT  - CGA
OT  - ET-1
OT  - MCP-1
OT  - altitude
OT  - p-selectin
OT  - platelet activation
EDAT- 2019/08/15 06:00
MHDA- 2020/09/09 06:00
CRDT- 2019/08/15 06:00
PHST- 2019/08/15 06:00 [pubmed]
PHST- 2020/09/09 06:00 [medline]
PHST- 2019/08/15 06:00 [entrez]
AID - 10.1089/ham.2018.0112 [doi]
PST - ppublish
SO  - High Alt Med Biol. 2019 Sep;20(3):318-321. doi: 10.1089/ham.2018.0112. Epub 2019 
      Aug 14.