PMID- 31412246
OWN - NLM
STAT- MEDLINE
DCOM- 20200904
LR  - 20200904
IS  - 2211-1247 (Electronic)
VI  - 28
IP  - 7
DP  - 2019 Aug 13
TI  - Maternal Antibodies Inhibit Neonatal and Infant Responses to Vaccination by 
      Shaping the Early-Life B Cell Repertoire within Germinal Centers.
PG  - 1773-1784.e5
LID - S2211-1247(19)30951-9 [pii]
LID - 10.1016/j.celrep.2019.07.047 [doi]
AB  - Maternal antibodies (MatAbs) protect offspring from infections but limit their 
      responses to vaccination. The mechanisms of this inhibition are still debated. 
      Using murine early-life immunization models mimicking the condition prevailing in 
      humans, we observed the induction of CD4-T, T follicular helper, and germinal 
      center (GC) B cell responses even when early-life antibody responses were 
      abrogated by MatAbs. GC B cells induced in the presence of MatAbs form GC 
      structures and exhibit canonical GC changes in gene expression but fail to 
      differentiate into plasma cells and/or memory B cells in a MatAb titer-dependent 
      manner. Furthermore, GC B cells elicited in the presence or absence of MatAbs use 
      different V(H) and V(k) genes and show differences in genes associated with B 
      cell differentiation and isotype switching. Thus, MatAbs do not prevent B cell 
      activation but control the output of the GC reaction both quantitatively and 
      qualitatively, shaping the antigen-specific B cell repertoire.
CI  - Copyright (c) 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Vono, Maria
AU  - Vono M
AD  - WHO Collaborative Center for Vaccine Immunology, Department of Pathology and 
      Immunology, University of Geneva, Geneva 1211, Switzerland. Electronic address: 
      maria.vono@unige.ch.
FAU - Eberhardt, Christiane Sigrid
AU  - Eberhardt CS
AD  - WHO Collaborative Center for Vaccine Immunology, Department of Pathology and 
      Immunology, University of Geneva, Geneva 1211, Switzerland.
FAU - Auderset, Floriane
AU  - Auderset F
AD  - WHO Collaborative Center for Vaccine Immunology, Department of Pathology and 
      Immunology, University of Geneva, Geneva 1211, Switzerland.
FAU - Mastelic-Gavillet, Beatris
AU  - Mastelic-Gavillet B
AD  - WHO Collaborative Center for Vaccine Immunology, Department of Pathology and 
      Immunology, University of Geneva, Geneva 1211, Switzerland.
FAU - Lemeille, Sylvain
AU  - Lemeille S
AD  - Department of Pathology and Immunology, University of Geneva, Geneva 1211, 
      Switzerland.
FAU - Christensen, Dennis
AU  - Christensen D
AD  - Vaccine Adjuvant Research, Department of Infectious Disease Immunology, Statens 
      Serum Institut, Copenhagen 2300, Denmark.
FAU - Andersen, Peter
AU  - Andersen P
AD  - Vaccine Adjuvant Research, Department of Infectious Disease Immunology, Statens 
      Serum Institut, Copenhagen 2300, Denmark; Department of Immunology and 
      Microbiology, University of Copenhagen, Copenhagen, 2300, Denmark.
FAU - Lambert, Paul-Henri
AU  - Lambert PH
AD  - WHO Collaborative Center for Vaccine Immunology, Department of Pathology and 
      Immunology, University of Geneva, Geneva 1211, Switzerland.
FAU - Siegrist, Claire-Anne
AU  - Siegrist CA
AD  - WHO Collaborative Center for Vaccine Immunology, Department of Pathology and 
      Immunology, University of Geneva, Geneva 1211, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Rep
JT  - Cell reports
JID - 101573691
RN  - 0 (Antibodies)
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Antibodies/blood/*immunology
MH  - Antibodies, Viral/blood/*immunology
MH  - Antibody Formation/*immunology
MH  - B-Lymphocytes/*immunology
MH  - Female
MH  - Germinal Center/*immunology
MH  - Immunization
MH  - Male
MH  - Maternal-Fetal Exchange/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Orthomyxoviridae/*immunology
MH  - Orthomyxoviridae Infections/immunology/virology
MH  - Pregnancy
MH  - T-Lymphocytes, Helper-Inducer/*immunology
MH  - Vaccination
OTO - NOTNLM
OT  - epitope masking
OT  - germinal centers
OT  - immunization
OT  - maternal antibodies
OT  - neonates
OT  - repertoire
EDAT- 2019/08/15 06:00
MHDA- 2020/09/05 06:00
CRDT- 2019/08/15 06:00
PHST- 2019/03/05 00:00 [received]
PHST- 2019/07/01 00:00 [revised]
PHST- 2019/07/15 00:00 [accepted]
PHST- 2019/08/15 06:00 [entrez]
PHST- 2019/08/15 06:00 [pubmed]
PHST- 2020/09/05 06:00 [medline]
AID - S2211-1247(19)30951-9 [pii]
AID - 10.1016/j.celrep.2019.07.047 [doi]
PST - ppublish
SO  - Cell Rep. 2019 Aug 13;28(7):1773-1784.e5. doi: 10.1016/j.celrep.2019.07.047.