PMID- 31413263
OWN - NLM
STAT- MEDLINE
DCOM- 20201109
LR  - 20210110
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Aug 14
TI  - CCT alpha is a novel biomarker for diagnosis of laryngeal squamous cell cancer.
PG  - 11823
LID - 10.1038/s41598-019-47895-x [doi]
LID - 11823
AB  - Choline phosphate-based delivery systems can target the acidic tumor 
      microenvironment. In this study, we set out to evaluate the diagnostic value of 
      Choline phosphate cytidylyltransferase-alpha (CCTalpha) in laryngeal squamous cell cancer 
      (LSCC). The expression of CCTalpha was detected using immunohistochemistry in 50 LSCC 
      patients' tissues and 16 vocal polyps as control group. Then, clinical data was 
      collected and we used receiver operating characteristic curve (ROC) to estimate 
      the potential of CCTalpha as diagnostic biomarker. We found CCTalpha levels to be 
      significantly high in the tissues derived from LSCC patients, (p < 0.001). 
      Further, we observed a positive correlation of CCTalpha with tumor size (p < 0.001), 
      TNM stage (p < 0.001), lymph node metastasis (p < 0.001) as well as the grade of 
      LSCC malignancy (p < 0.001). Furthermore, AUC was determined to be 0.939 by ROC, 
      and the optimal cutoff value 3.100, with 76.0% sensitivity and 100% specificity. 
      We also found an epigenetic basis of CCTalpha over-expression in LSCC tissues with 
      significantly reduced methylation of CCTalpha in LSCC tissues, compared to vocal 
      polyps (p < 0.001). These results support epigenetically-induced over-expression 
      of CCTalpha as a potential diagnostic marker for LSCC.
FAU - Yang, Jingpu
AU  - Yang J
AD  - Department of Otolaryngology-Head and Neck Surgery, The Second Hospital of Jilin 
      University, 218 Ziqiang Street, Changchun, 130041, China.
FAU - Zhang, Zhuping
AU  - Zhang Z
AD  - Department of Otolaryngology-Head and Neck Surgery, The Central Hospital of 
      Wuhan, 26 Shengli Street, Wuhan, 430014, China.
FAU - Zhao, Yin
AU  - Zhao Y
AD  - Department of Otolaryngology-Head and Neck Surgery, The Second Hospital of Jilin 
      University, 218 Ziqiang Street, Changchun, 130041, China.
FAU - Cheng, Jinzhang
AU  - Cheng J
AD  - Department of Otolaryngology-Head and Neck Surgery, The Second Hospital of Jilin 
      University, 218 Ziqiang Street, Changchun, 130041, China.
FAU - Zhao, Chang
AU  - Zhao C
AD  - Department of Otolaryngology-Head and Neck Surgery, The Second Hospital of Jilin 
      University, 218 Ziqiang Street, Changchun, 130041, China.
FAU - Wang, Zonggui
AU  - Wang Z
AD  - Department of Otolaryngology-Head and Neck Surgery, The Second Hospital of Jilin 
      University, 218 Ziqiang Street, Changchun, 130041, China. zg_wang@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190814
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Biomarkers, Tumor)
RN  - EC 2.7.7.15 (Choline-Phosphate Cytidylyltransferase)
SB  - IM
EIN - Sci Rep. 2020 Nov 20;10(1):20627. PMID: 33219266
MH  - Aged
MH  - Biomarkers, Tumor/*metabolism
MH  - Case-Control Studies
MH  - Choline-Phosphate Cytidylyltransferase/*metabolism
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*diagnosis/pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Squamous Cell Carcinoma of Head and Neck/*diagnosis/pathology
MH  - Tumor Microenvironment
PMC - PMC6694151
COIS- The authors declare no competing interests.
EDAT- 2019/08/16 06:00
MHDA- 2020/11/11 06:00
PMCR- 2019/08/14
CRDT- 2019/08/16 06:00
PHST- 2019/03/25 00:00 [received]
PHST- 2019/06/18 00:00 [accepted]
PHST- 2019/08/16 06:00 [entrez]
PHST- 2019/08/16 06:00 [pubmed]
PHST- 2020/11/11 06:00 [medline]
PHST- 2019/08/14 00:00 [pmc-release]
AID - 10.1038/s41598-019-47895-x [pii]
AID - 47895 [pii]
AID - 10.1038/s41598-019-47895-x [doi]
PST - epublish
SO  - Sci Rep. 2019 Aug 14;9(1):11823. doi: 10.1038/s41598-019-47895-x.