PMID- 31413617
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 1178-7031 (Print)
IS  - 1178-7031 (Electronic)
IS  - 1178-7031 (Linking)
VI  - 12
DP  - 2019
TI  - Effect of thermal spring water on human dendritic cell inflammatory response.
PG  - 181-194
LID - 10.2147/JIR.S213594 [doi]
AB  - BACKGROUND: Hydrotherapy appears as a valuable therapeutic tool in the management 
      of patients suffering from chronic skin inflammatory diseases. Nevertheless, the 
      underlying immune mechanisms of these beneficial effects remain poorly 
      understood. To better understand the biological effects of thermal spring water 
      on the immune system, we investigated the effects of Avene thermal spring water 
      (ASW) on dendritic cells as key cells participating in the control of the immune 
      response. METHODS: Dendritic cells (DCs) were generated from human monocytes and 
      matured with LPS in ASW-based culture medium or in dexamethasone supplemented 
      culture medium as an anti-inflammatory treatment. The phenotypes and abilities of 
      these DCs to produce cytokines and induce allogeneic T cell response was next 
      assessed. RESULTS: We showed that ASW modulated the differentiation of monocytes 
      into DCs and impacted the DC maturation upon LPS priming. We observed a reduction 
      of the CD83, CD86, CD1a and HLA-DR molecule expression and a decrease of IL-12 
      and IL-23 production whereas IL-10 production was increased. LPS-primed DCs 
      generated in presence of ASW exhibited a reduced capacity to induce naive CD4(+) 
      T cell proliferation and IFN-gamma and IL-17 production. CONCLUSION: Our study showed 
      that ASW is endowed with an immunomodulatory potential. ASW limits the DC 
      stimulatory capacity of Th1 and Th17 cell responses by impairing their 
      maturation, IL-12 and IL-23 production and accessory cell function.
FAU - Eliasse, Yoan
AU  - Eliasse Y
AD  - INSERM U1037, Centre de Recherche en Cancerologie de Toulouse (CRCT), Toulouse 
      F-31037, France.
AD  - Universite De Toulouse, Universite Paul Sabatier, Toulouse F-31062, France.
FAU - Galliano, Marie-Florence
AU  - Galliano MF
AD  - Research and Development, Pierre Fabre Dermo-Cosmetique, Toulouse, France.
FAU - Redoules, Daniel
AU  - Redoules D
AD  - Global Medical Direction, Laboratoire Dermatologique Avene, Pierre Fabre 
      Dermo-Cosmetique, Toulouse, France.
FAU - Espinosa, Eric
AU  - Espinosa E
AD  - INSERM U1037, Centre de Recherche en Cancerologie de Toulouse (CRCT), Toulouse 
      F-31037, France.
AD  - Universite De Toulouse, Universite Paul Sabatier, Toulouse F-31062, France.
LA  - eng
PT  - Journal Article
DEP - 20190722
PL  - New Zealand
TA  - J Inflamm Res
JT  - Journal of inflammation research
JID - 101512684
PMC - PMC6660632
OTO - NOTNLM
OT  - dendritic cells
OT  - dexamethasone
OT  - hydrotherapy
OT  - inflammation
OT  - naive CD4+ T cells
COIS- D.R and M-F.G are employees of Pierre Fabre Dermo-Cosmetique. Y.E. reports grants 
      from Laboratoires Pierre Fabre, during the conduct of the study. E.E. reports 
      grants from Laboratoires Pierre Fabre, during the conduct of the study. He also 
      received grants and personal fees from Laboratoires Pierre Fabre, outside the 
      submitted work. The authors report no other conflicts of interest in this work.
EDAT- 2019/08/16 06:00
MHDA- 2019/08/16 06:01
PMCR- 2019/07/22
CRDT- 2019/08/16 06:00
PHST- 2019/04/26 00:00 [received]
PHST- 2019/06/28 00:00 [accepted]
PHST- 2019/08/16 06:00 [entrez]
PHST- 2019/08/16 06:00 [pubmed]
PHST- 2019/08/16 06:01 [medline]
PHST- 2019/07/22 00:00 [pmc-release]
AID - 213594 [pii]
AID - 10.2147/JIR.S213594 [doi]
PST - epublish
SO  - J Inflamm Res. 2019 Jul 22;12:181-194. doi: 10.2147/JIR.S213594. eCollection 
      2019.