PMID- 31413946
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2214-7500 (Electronic)
IS  - 2214-7500 (Linking)
VI  - 6
DP  - 2019
TI  - Renal and testicular up-regulation of pro-inflammatory chemokines (RANTES and 
      CCL2) and cytokines (TNF-alpha, IL-1beta, IL-6) following acute edible camphor 
      administration is through activation of NF-kB in rats.
PG  - 759-767
LID - 10.1016/j.toxrep.2019.07.010 [doi]
AB  - Camphor-induced oxidative stress and histopathological changes (in brain, lung, 
      liver, kidney and testes) have been reported. We therefore investigated the 
      effect of various doses of camphor in an acute study, on renal and testicular 
      levels of some pro-inflammatory mediators in male wistar rats. Twenty rats 
      divided into four groups of five rats each were used in this study. Group 1 
      served as control and was administered 6 mL/kg olive oil, the vehicle for 
      camphor, while groups 2, 3 and 4 were orally administered 1000, 2000, and 
      4000 mg/kg body weight camphor, for seven days. Compared with control, levels of 
      tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta) and interleukin 6 
      (IL-6) were significantly increased kidney and testes by 2000 and 4000 mg/kg body 
      weight, while interleukin 10 (IL-10) was only significantly increased by 
      1000 mg/kg body weight of camphor in both tissues. Also compared with control, 
      all doses of camphor administered resulted in a significant increase in the 
      expressions of renal and testicular nuclear factor kappa B (NFkB), cyclooxygenase 
      2 (COX-2), regulated upon activation normal T cell expressed and secreted 
      (RANTES), and monocyte chemo-attractant protein 1 (MCP-1). Conclusively, use and 
      consumption of camphor should be with caution as it could trigger renal and 
      testicular inflammation through activation of NF-kB and up-regulation of 
      pro-inflammatory markers.
FAU - Somade, Oluwatobi T
AU  - Somade OT
AD  - Department of Biochemistry, College of Biosciences, Federal University of 
      Agriculture, Abeokuta, Nigeria.
FAU - Ajayi, Babajide O
AU  - Ajayi BO
AD  - Department of Biochemistry, Bowen University, Iwo, Nigeria.
FAU - Safiriyu, Oluwaseyi A
AU  - Safiriyu OA
AD  - Department of Biochemistry, College of Biosciences, Federal University of 
      Agriculture, Abeokuta, Nigeria.
FAU - Oyabunmi, Oluwasola S
AU  - Oyabunmi OS
AD  - Department of Biochemistry, College of Biosciences, Federal University of 
      Agriculture, Abeokuta, Nigeria.
FAU - Akamo, Adio J
AU  - Akamo AJ
AD  - Department of Biochemistry, College of Biosciences, Federal University of 
      Agriculture, Abeokuta, Nigeria.
LA  - eng
PT  - Journal Article
DEP - 20190731
PL  - Ireland
TA  - Toxicol Rep
JT  - Toxicology reports
JID - 101630272
PMC - PMC6687103
OTO - NOTNLM
OT  - Camphor
OT  - Chemokines
OT  - Cytokines
OT  - Pro-inflammation
OT  - Renal
OT  - Testicular
COIS- None to declare.
EDAT- 2019/08/16 06:00
MHDA- 2019/08/16 06:01
PMCR- 2019/07/31
CRDT- 2019/08/16 06:00
PHST- 2019/04/08 00:00 [received]
PHST- 2019/07/26 00:00 [revised]
PHST- 2019/07/30 00:00 [accepted]
PHST- 2019/08/16 06:00 [entrez]
PHST- 2019/08/16 06:00 [pubmed]
PHST- 2019/08/16 06:01 [medline]
PHST- 2019/07/31 00:00 [pmc-release]
AID - S2214-7500(19)30202-1 [pii]
AID - 10.1016/j.toxrep.2019.07.010 [doi]
PST - epublish
SO  - Toxicol Rep. 2019 Jul 31;6:759-767. doi: 10.1016/j.toxrep.2019.07.010. 
      eCollection 2019.