PMID- 31414088
OWN - NLM
STAT- MEDLINE
DCOM- 20200213
LR  - 20200213
IS  - 2515-4184 (Electronic)
IS  - 2515-4184 (Linking)
VI  - 15
IP  - 5
DP  - 2019 Oct 7
TI  - Reduced sialyl-Lewis(x) on salivary MUC7 from patients with burning mouth 
      syndrome.
PG  - 331-339
LID - 10.1039/c9mo00061e [doi]
AB  - We analysed and compared MUC7 O-glycosylation and inflammatory biomarkers in 
      saliva from female patients with burning mouth syndrome (BMS) and 
      gender/age-matched controls. Oligosaccharides from salivary MUC7 from BMS and 
      controls were released. Inflammatory mediators were measured by multiplex 
      proximity extension assay. Presence of sialyl-Lewisx (Si-Lex) epitope on MUC7 was 
      confirmed using Western blot. MUC7 O-glycans and measured inflammatory biomarkers 
      were found to be similar between BMS and controls. However, oligosaccharides 
      sialyl-Lewisx (Si-Lex) was found to be reduced in samples from BMS patients. 
      Positive correlation (combined patients and controls) was found between levels of 
      C-C motif chemokine 19 (CCL-19) and the amount of core-2 oligosaccharides on MUC7 
      as well as fractalkine (CX3CL1) and level of sialylation. Patients with BMS were 
      shown to represent a heterogeneous group in terms of inflammatory biomarkers. 
      This indicates that BMS patients could be further stratified on the basis of 
      low-level inflammation. The results furthermore indicate that reduced sialylation 
      of MUC7, particularly Si-Lex, may be an important feature in patients with BMS. 
      However, the functional aspects and potential involvement in immune regulation of 
      Si-Lex remains unclear. Our data suggests a chemokine driven alteration of MUC7 
      glycosylation.
FAU - Acharya, Shikha
AU  - Acharya S
AD  - Department of Oral Microbiology and Immunology, Institute of Odontology, The 
      Sahlgrenska Academy, University of Gothenburg, PO 450, 40530, Gothenburg, Sweden. 
      shikha.acharya@gu.se.
FAU - Jin, Chunsheng
AU  - Jin C
FAU - Bylund, Johan
AU  - Bylund J
FAU - Shen, Qiujin
AU  - Shen Q
FAU - Kamali-Moghaddam, Masood
AU  - Kamali-Moghaddam M
FAU - Jontell, Mats
AU  - Jontell M
FAU - Carlen, Anette
AU  - Carlen A
FAU - Karlsson, Niclas G
AU  - Karlsson NG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Mol Omics
JT  - Molecular omics
JID - 101713384
RN  - 0 (MUC7 protein, human)
RN  - 0 (Mucins)
RN  - 0 (Salivary Proteins and Peptides)
RN  - 0 (Sialyl Lewis X Antigen)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Burning Mouth Syndrome/*genetics/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mucins/*metabolism
MH  - Salivary Proteins and Peptides/*metabolism
MH  - Sialyl Lewis X Antigen/*metabolism
EDAT- 2019/08/16 06:00
MHDA- 2020/02/14 06:00
CRDT- 2019/08/16 06:00
PHST- 2019/08/16 06:00 [pubmed]
PHST- 2020/02/14 06:00 [medline]
PHST- 2019/08/16 06:00 [entrez]
AID - 10.1039/c9mo00061e [doi]
PST - ppublish
SO  - Mol Omics. 2019 Oct 7;15(5):331-339. doi: 10.1039/c9mo00061e.