PMID- 31414167
OWN - NLM
STAT- MEDLINE
DCOM- 20200825
LR  - 20200825
IS  - 1435-1269 (Electronic)
IS  - 0948-6704 (Linking)
VI  - 53
IP  - 5
DP  - 2020 Aug
TI  - Effect of antithrombotic drugs on bone health.
PG  - 457-462
LID - 10.1007/s00391-019-01590-8 [doi]
AB  - With the increasing consumption of antithrombotic drugs among old people, 
      expected as well as unexpected side effects on bone health are considerable, e.g. 
      osteoporosis, fragility fractures, etc. This review focuses on antithrombotic 
      drugs and their effects on bone health. The following groups were reviewed: 
      parenteral long-term use of unfractionated heparin (UFH) is associated with 
      osteopenia. The oral intake of vitamin K antagonists (VKA) makes them more 
      convenient than UFH but chronic use also results in osteopenia. Limited reports 
      of bone loss have been associated with low molecular weight heparins (LMWH) and 
      indirect factor Xa inhibitors but in contrast to VKA and UFH they are less 
      associated with osteopenia. There have been limited studies evaluating the effect 
      of new oral anticoagulants (NOACs) on bones. Overall, they are considered safer 
      than other drugs. There have been no reports about acetylsalicylic acid (ASA) and 
      clopidogrel causing osteopenia but their metabolism by the kidneys and liver can 
      cause reduced 25-hydroxy-vitamin D levels and can theoretically contribute to 
      osteoporosis. Some reports suggested that high dosage clopidogrel can also 
      negatively affect bones. After a detailed literature review long-term use of 
      antithrombotic drugs can negatively affect the bones. Their role in bone health 
      needs to be studied in detail and the clinical use in geriatric patients should 
      be prudent.
FAU - Dadwal, G
AU  - Dadwal G
AD  - Department of Traumatology, Bonifatius Hospital Lingen, Wilhelmstrasse 13, 49808, 
      Lingen (Ems), Germany. gaurav.dadwal@hospital-lingen.de.
FAU - Schulte-Huxel, T
AU  - Schulte-Huxel T
AD  - Department of Traumatology, Bonifatius Hospital Lingen, Wilhelmstrasse 13, 49808, 
      Lingen (Ems), Germany.
FAU - Kolb, G
AU  - Kolb G
AD  - Department of Geriatrics and Physical Rehabilitation, Clinic of Internal 
      Medicine, Bonifatius Hospital Lingen, Wilhelmstrasse 13, 49808, Lingen (Ems), 
      Germany.
LA  - eng
PT  - Journal Article
PT  - Review
TT  - Auswirkung von Antithrombotika auf den Knochen.
DEP - 20190814
PL  - Germany
TA  - Z Gerontol Geriatr
JT  - Zeitschrift fur Gerontologie und Geriatrie
JID - 9506215
RN  - 0 (Anticoagulants)
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Administration, Oral
MH  - Aged
MH  - Anticoagulants/*adverse effects/therapeutic use
MH  - Bone Density/*drug effects
MH  - Fibrinolytic Agents/*adverse effects/therapeutic use
MH  - Heparin/*adverse effects/therapeutic use
MH  - Heparin, Low-Molecular-Weight/*adverse effects/therapeutic use
MH  - Humans
MH  - Osteoporosis/chemically induced
OTO - NOTNLM
OT  - Geriatrics
OT  - NOAC
OT  - Osteoporosis
OT  - Trauma
OT  - Warfarin
EDAT- 2019/08/16 06:00
MHDA- 2020/08/26 06:00
CRDT- 2019/08/16 06:00
PHST- 2019/03/24 00:00 [received]
PHST- 2019/07/16 00:00 [accepted]
PHST- 2019/08/16 06:00 [pubmed]
PHST- 2020/08/26 06:00 [medline]
PHST- 2019/08/16 06:00 [entrez]
AID - 10.1007/s00391-019-01590-8 [pii]
AID - 10.1007/s00391-019-01590-8 [doi]
PST - ppublish
SO  - Z Gerontol Geriatr. 2020 Aug;53(5):457-462. doi: 10.1007/s00391-019-01590-8. Epub 
      2019 Aug 14.