PMID- 31414907
OWN - NLM
STAT- MEDLINE
DCOM- 20191127
LR  - 20210204
IS  - 1530-891X (Print)
IS  - 1530-891X (Linking)
VI  - 25
IP  - 11
DP  - 2019 Nov
TI  - THE ASSOCIATION OF GESTATIONAL WEIGHT GAIN AND ADVERSE PREGNANCY OUTCOMES IN 
      WOMEN WITH GESTATIONAL DIABETES MELLITUS.
PG  - 1137-1150
LID - 10.4158/EP-2019-0011 [doi]
AB  - Objective: To explore the association of excessive gestational weight gain (GWG) 
      defined by the Institute of Medicine (IOM) targets and adverse perinatal outcomes 
      in gestational diabetes mellitus (GDM) pregnancies, and whether a modified target 
      might be related to a lower rate of adverse perinatal outcomes for GDM. Methods: 
      This retrospective cohort study involved 1,138 women of normal glucose tolerance 
      (NGT) and 1,200 women with GDM. Based on the IOM target, pregnancies were 
      classified to appropriate GWG (aGWG), inadequate GWG, and excessive GWG (eGWG). 
      Modified GWG targets included: upper limit of IOM target minus 1 kg (IOM-1) or 2 
      kg (IOM-2), both upper and lower targets minus 1 kg (IOM-1-1) or 2 kg (IOM-2-2). 
      Results: The proportions of women achieving eGWG were 26.3% in NGT and 31.2% in 
      GDM (P = .036); in comparison, for aGWG NGT, the risks of large for gestational 
      age (LGA) were significantly higher in eGWG NGT (adjusted odds ratio [OR] 1.47; 
      95% confidence interval [CI] 1.02 to 2.13), aGWG GDM (adjusted OR 1.42; 95% CI 
      1.03 to 1.95), and eGWG GDM (adjusted OR 2.70; 95% CI 1.92 to 3.70). GDM 
      pregnancies gaining aGWG based on the modified GWG targets (IOM-2, IOM-1-1, and 
      IOM-2-2) had a lower prevalence of LGA and macrosomia delivery than that for 
      similar pregnancies using the original IOM target (all P<.05). Conclusion: For 
      aGWG GDM according to the IOM target, adhering to a more stringent weight control 
      was associated with decreased adverse outcomes. A tighter IOM target might help 
      to reduce the prevalence of adverse pregnancy outcomes. Abbreviations: aGWG = 
      appropriate gestational weight gain; BG = blood glucose; BMI = body mass index; 
      CI = confidence interval; eGWG = excessive gestational weight gain; GDM = 
      gestational diabetes mellitus; GW = gestational weeks; GWG = gestational weight 
      gain; HbA1c = hemoglobin A1c; iGWG = inadequate gestational weight gain; IOM = 
      Institute of Medicine; LGA = large for gestational age; NGT = normal glucose 
      tolerance; NICU = neonatal intensive care unit; OGTT = oral glucose tolerance 
      test; OR = odds ratio; PARp = partial population attributable risks; SGA = small 
      for gestational age.
FAU - Xu, Qianyue
AU  - Xu Q
FAU - Ge, Zhijuan
AU  - Ge Z
FAU - Hu, Jun
AU  - Hu J
FAU - Shen, Shanmei
AU  - Shen S
FAU - Bi, Yan
AU  - Bi Y
FAU - Zhu, Dalong
AU  - Zhu D
LA  - eng
PT  - Journal Article
DEP - 20190815
PL  - United States
TA  - Endocr Pract
JT  - Endocrine practice : official journal of the American College of Endocrinology 
      and the American Association of Clinical Endocrinologists
JID - 9607439
SB  - IM
MH  - Body Mass Index
MH  - *Diabetes, Gestational
MH  - Female
MH  - Gestational Weight Gain
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Retrospective Studies
MH  - Weight Gain
EDAT- 2019/08/16 06:00
MHDA- 2019/11/28 06:00
CRDT- 2019/08/16 06:00
PHST- 2019/08/16 06:00 [pubmed]
PHST- 2019/11/28 06:00 [medline]
PHST- 2019/08/16 06:00 [entrez]
AID - S1530-891X(20)35135-1 [pii]
AID - 10.4158/EP-2019-0011 [doi]
PST - ppublish
SO  - Endocr Pract. 2019 Nov;25(11):1137-1150. doi: 10.4158/EP-2019-0011. Epub 2019 Aug 
      15.