PMID- 31415858
OWN - NLM
STAT- MEDLINE
DCOM- 20200415
LR  - 20200415
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 140
DP  - 2019 Nov 1
TI  - Fabrication of water compatible and biodegradable super-paramagnetic molecularly 
      imprinted nanoparticles for selective separation of memantine from human serum 
      prior to its quantification: An efficient and green pathway.
PG  - 140-148
LID - S0141-8130(19)33444-0 [pii]
LID - 10.1016/j.ijbiomac.2019.08.099 [doi]
AB  - A novel green magnetic molecularly imprinted solid phase extraction (MMI-SPE) for 
      separation of memantine (MEM) from complicated matrices was proposed. The 
      nanomaterial was synthesized via crosslinking of chitosan (CHIT) with [3-(2, 
      3-epoxypropoxy)-propyl] trimethoxysilane (EPPTMS) in presence of MEM as a 
      template. The nanocomposites, in all steps, were characterized by SEM, FTIR and 
      PXRD techniques. The adsorbed drug was removed from magnetic molecular imprinted 
      polymer (MMIP) cavity by ethanol: acetic acid (8:2, v/v) and then, coupled with 
      sodium 1, 2-naphthoquinone-4-sulphonate (NQS) in iodine/alkaline medium to yield 
      highly fluorescent product, after reduction with potassium borohydride (KBH(4)). 
      Variables affecting extraction of MEM from imprinted sites and its fluorometric 
      analysis were studied. The linearity was achieved over concentration range of 
      1.84-95.0 ng mL(-1) with LOD of 0.6 ng mL(-1). The method was successfully 
      applied for determination of MEM in its pharmaceutical tablets and human serum 
      with recoveries of 100.8 +/- 3.0, 97.6 +/- 2.9, respectively.
CI  - Copyright (c) 2019. Published by Elsevier B.V.
FAU - Mohamed, Fardous A
AU  - Mohamed FA
AD  - Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut 
      University, Egypt.
FAU - Khashaba, Pakinaz Y
AU  - Khashaba PY
AD  - Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut 
      University, Egypt; Department of Pharmaceutical Analytical Chemistry, Faculty of 
      Pharmacy, Deraya University, El-Minya, Egypt.
FAU - El-Wekil, Mohamed M
AU  - El-Wekil MM
AD  - Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut 
      University, Egypt.
FAU - Shahin, Reem Y
AU  - Shahin RY
AD  - Drug Research Center, Assiut University, Egypt. Electronic address: 
      reemshain19@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20190812
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Biodegradable Plastics)
RN  - 0 (Magnetite Nanoparticles)
RN  - 059QF0KO0R (Water)
RN  - 9012-76-4 (Chitosan)
RN  - W8O17SJF3T (Memantine)
SB  - IM
MH  - Biodegradable Plastics/*chemistry
MH  - Chitosan/*chemistry
MH  - Green Chemistry Technology
MH  - Humans
MH  - Magnetite Nanoparticles/*chemistry
MH  - Memantine/chemistry/*isolation & purification
MH  - Molecular Imprinting
MH  - Serum/*chemistry
MH  - Water/*chemistry
OTO - NOTNLM
OT  - Fluorimetry
OT  - Human serum
OT  - Magnetic molecular imprinted polymer
OT  - Memantine
OT  - Sodium 1, 2-naphthoquinone 4-sulphonate
EDAT- 2019/08/16 06:00
MHDA- 2020/04/16 06:00
CRDT- 2019/08/16 06:00
PHST- 2019/05/09 00:00 [received]
PHST- 2019/08/04 00:00 [revised]
PHST- 2019/08/11 00:00 [accepted]
PHST- 2019/08/16 06:00 [pubmed]
PHST- 2020/04/16 06:00 [medline]
PHST- 2019/08/16 06:00 [entrez]
AID - S0141-8130(19)33444-0 [pii]
AID - 10.1016/j.ijbiomac.2019.08.099 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2019 Nov 1;140:140-148. doi: 10.1016/j.ijbiomac.2019.08.099. 
      Epub 2019 Aug 12.