PMID- 31418377 OWN - NLM STAT- MEDLINE DCOM- 20190827 LR - 20190827 IS - 1009-2137 (Print) IS - 1009-2137 (Linking) VI - 27 IP - 4 DP - 2019 Aug TI - [Significance of Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in Patients with Multiple Myeloma]. PG - 1185-1189 LID - 10.19746/j.cnki.issn.1009-2137.2019.04.031 [doi] AB - OBJECTIVE: To investigate the significance of neutrophil/lymphocyte ratio(NLR) and platelet/lymphocyte ratio(PLR) in patients with multiple myeloma (MM). METHODS: Eighty patients with multiple myeloma admitted in our hospital from August 2007 to August 2010 were selected. The clinical data of the patients, including hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red blood cell distribution width (RDW), white blood cell(WBC) count, absolute neutrophil count (ANC), platelet count (PC), glomerular filtration rate (GFR), calcium, albumin, beta2 microglobulin and so on were collected and analyzed. RESULTS: The optimal threshold of NLR was 2.78 (sensitivity: 83.3%, specificity: 43.1%). The optimal threshold of PLR was 155.58 (sensitivity: 67.7%, specificity: 36.9%). All patients were grouped according to NLR and PLR values, patients with high NLR and PLR had lower albumin levels and higher clinical stages. High NLR patients were mainly men, hemoglobin, GFR values, albumin levels were lower, and the white blood cells count and beta2 microglobulin level were higher. High PLR patients showed low albumin level and higher clinical stage. Multivariate analysis showed that beta2 microglobulin and NLR were prognostic factors in patients with multiple myeloma (P<0.05). Kaplan-Meier survival analysis showed that the median survival time was 37 months (95% CI: 21.80-52.19) for patients with high NLR and 66 months (95% CI: 53.19-78.80) for patients with low NLR. The median survival time was 45 months (95% CI: 0.00 to 91.18) in patients with high PLR and 62 months (95% CI: 45.67-78.33) in patients with low PLR. CONCLUSION: High NLR (>2.78) associates with poor prognosis in patients with MM, and it may be considered as an independent prognostic factor for MM patients. FAU - Sun, Ju-Yong AU - Sun JY AD - Department of Clinical Laboratorial Examination,Harrison International Peace Hospital. FAU - Mu, Na AU - Mu N AD - Department of Clinical Laboratorial Examination,Harrison International Peace Hospital. FAU - Mu, Jia AU - Mu J AD - Department of Clinical Laboratorial squareExamination,Hengshui Maternal and Child Health Hospital. FAU - Zhang, Chang-Geng AU - Zhang CG AD - Department of Clinical Laboratorial Examination,Harrison International Peace Hospital,E-mail: 13831839080@163.com. FAU - Wang, Dong-Mei AU - Wang DM AD - Department of Hematology, Harrison International Peace Hospital,Hengshui 053000,Hebei Province, China. LA - chi PT - Journal Article PL - China TA - Zhongguo Shi Yan Xue Ye Xue Za Zhi JT - Zhongguo shi yan xue ye xue za zhi JID - 101084424 SB - IM MH - Blood Platelets MH - Humans MH - Lymphocytes MH - Male MH - *Multiple Myeloma MH - *Neutrophils MH - Prognosis MH - Retrospective Studies EDAT- 2019/08/17 06:00 MHDA- 2019/08/28 06:00 CRDT- 2019/08/17 06:00 PHST- 2019/08/17 06:00 [entrez] PHST- 2019/08/17 06:00 [pubmed] PHST- 2019/08/28 06:00 [medline] AID - 1009-2137(2019)04-1185-05 [pii] AID - 10.19746/j.cnki.issn.1009-2137.2019.04.031 [doi] PST - ppublish SO - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Aug;27(4):1185-1189. doi: 10.19746/j.cnki.issn.1009-2137.2019.04.031.