PMID- 31419376
OWN - NLM
STAT- MEDLINE
DCOM- 20200226
LR  - 20211204
IS  - 1399-3062 (Electronic)
IS  - 1398-2273 (Linking)
VI  - 21
IP  - 5
DP  - 2019 Oct
TI  - A case of immune reconstitution syndrome complicating progressive multifocal 
      leukoencephalopathy after kidney transplant: Clinical, pathological, and 
      radiographic features.
PG  - e13162
LID - 10.1111/tid.13162 [doi]
AB  - Progressive multifocal leukoencephalopathy (PML) is a life-threatening central 
      nervous system (CNS) disorder, most commonly described in patients infected with 
      the human immunodeficiency virus (HIV). Limited data exist on its natural history 
      and treatment in solid organ transplant (SOT) recipients. A complication of PML 
      is the immune reconstitution inflammatory syndrome (IRIS), which develops after T 
      cell reconstitution and can have severe consequences when it occurs in the CNS. 
      While well described in HIV-infected individuals, its clinical features, 
      diagnosis, and treatment after SOT are largely unknown. We report a case of a 
      kidney transplant recipient who was diagnosed with PML and developed significant 
      worsening of her symptoms upon reduction of immunosuppression. Thallium SPECT 
      showed avid uptake suggestive of lymphoma, but the diagnosis of PML-IRIS was 
      ultimately established by brain biopsy. She survived with nearly complete 
      restoration of her functional status after a prolonged steroid taper.
CI  - (c) 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Jackowiak, Eric
AU  - Jackowiak E
AUID- ORCID: 0000-0001-8316-9781
AD  - Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, 
      Pennsylvania.
FAU - Shah, Nirav
AU  - Shah N
AD  - Division of Nephrology, University of Pittsburgh Medical Center, Pittsburgh, 
      Pennsylvania.
FAU - Chen, Huiwen
AU  - Chen H
AD  - Division of Nephrology, University of Pittsburgh Medical Center, Pittsburgh, 
      Pennsylvania.
FAU - Ojha, Ajitesh
AU  - Ojha A
AD  - Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, 
      Pennsylvania.
FAU - Doyle, John
AU  - Doyle J
AD  - Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, 
      Pennsylvania.
FAU - Shepler, Anne
AU  - Shepler A
AD  - Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, 
      Pennsylvania.
FAU - Bogdanovich, Tatiana
AU  - Bogdanovich T
AD  - Division of Infectious Diseases, University of Pittsburgh Medical Center, 
      Pittsburgh, Pennsylvania.
FAU - Silveira, Fernanda P
AU  - Silveira FP
AD  - Division of Infectious Diseases, University of Pittsburgh Medical Center, 
      Pittsburgh, Pennsylvania.
FAU - Haidar, Ghady
AU  - Haidar G
AUID- ORCID: 0000-0003-0634-8211
AD  - Division of Infectious Diseases, University of Pittsburgh Medical Center, 
      Pittsburgh, Pennsylvania.
LA  - eng
PT  - Case Reports
DEP - 20190903
PL  - Denmark
TA  - Transpl Infect Dis
JT  - Transplant infectious disease : an official journal of the Transplantation 
      Society
JID - 100883688
SB  - IM
MH  - Biopsy
MH  - Brain/diagnostic imaging/pathology
MH  - Female
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*complications/*diagnostic imaging
MH  - Immunosuppression Therapy
MH  - Kidney Transplantation/*adverse effects
MH  - Leukoencephalopathy, Progressive Multifocal/*complications/*diagnostic imaging
MH  - Magnetic Resonance Imaging
MH  - Middle Aged
MH  - Speech Intelligibility
OTO - NOTNLM
OT  - JC virus
OT  - immune reconstitution inflammatory syndrome (IRIS)
OT  - progressive multifocal leukoencephalopathy (PML)
OT  - renal transplant
OT  - solid organ transplant
OT  - thallium SPECT scan
EDAT- 2019/08/17 06:00
MHDA- 2020/02/27 06:00
CRDT- 2019/08/17 06:00
PHST- 2019/05/08 00:00 [received]
PHST- 2019/07/12 00:00 [revised]
PHST- 2019/08/11 00:00 [accepted]
PHST- 2019/08/17 06:00 [pubmed]
PHST- 2020/02/27 06:00 [medline]
PHST- 2019/08/17 06:00 [entrez]
AID - 10.1111/tid.13162 [doi]
PST - ppublish
SO  - Transpl Infect Dis. 2019 Oct;21(5):e13162. doi: 10.1111/tid.13162. Epub 2019 Sep 
      3.