PMID- 3142198
OWN - NLM
STAT- MEDLINE
DCOM- 19881208
LR  - 20190814
IS  - 0001-5172 (Print)
IS  - 0001-5172 (Linking)
VI  - 32
IP  - 7
DP  - 1988 Oct
TI  - Suppression of the pressor effect of centrally administered thyrotropin-releasing 
      hormone under halothane, pentobarbital and flunitrazepam anaesthesia.
PG  - 535-40
AB  - Intracerebroventricular (i.c.v.) administration of thyrotropin-releasing hormone 
      (TRH) caused an increase in blood pressure (BP) and heart rate (HR) in conscious 
      rats. The pressor effect was greatly diminished by adrenalectomy as well as after 
      pretreatment with phentolamine, an alpha-receptor antagonist or with 
      mecamylamine, a ganglion blocker, suggesting that centrally administered TRH 
      increases BP mainly by stimulating sympathetic activity. Under halothane (0.8%), 
      pentobarbital (33 mg/kg, i.p.) and flunitrazepam (0.8 mg/kg, i.v.) anaesthesia, 
      the pressor effect of TRH was almost completely blocked. The increase in BP 
      induced by peripheral alpha-receptor stimulation with phenylephrine was not 
      affected by the anaesthetics at these doses. Pretreatment with atropine (50 
      micrograms, i.c.v.) significantly reduced the pressor effect of TRH. 
      Intracerebroventricularly administered haloperidol and bicuculline also partially 
      diminished the increase in BP produced by TRH, while other neurotransmitter 
      blockers such as phentolamine, propranolol and naloxone did not. These results 
      indicate that the anaesthetics at the doses employed interfere with the central 
      neuronal pathway(s), probably cholinergic pathways, through which TRH exerts its 
      pressor effect.
FAU - Tanaka, H
AU  - Tanaka H
AD  - Department of Anaesthesiology, Kyoto Prefectural University of Medicine, Japan.
FAU - Okuda, C
AU  - Okuda C
FAU - Sawa, T
AU  - Sawa T
FAU - Mizobe, T
AU  - Mizobe T
FAU - Demura, H
AU  - Demura H
FAU - Miyazaki, M
AU  - Miyazaki M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Acta Anaesthesiol Scand
JT  - Acta anaesthesiologica Scandinavica
JID - 0370270
RN  - 5Y5F15120W (Thyrotropin-Releasing Hormone)
RN  - 620X0222FQ (Flunitrazepam)
RN  - I4744080IR (Pentobarbital)
RN  - UQT9G45D1P (Halothane)
SB  - IM
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Depression, Chemical
MH  - Flunitrazepam/*pharmacology
MH  - Halothane/*pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Pentobarbital/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Thyrotropin-Releasing Hormone/administration & dosage/*antagonists & inhibitors
EDAT- 1988/10/01 00:00
MHDA- 1988/10/01 00:01
CRDT- 1988/10/01 00:00
PHST- 1988/10/01 00:00 [pubmed]
PHST- 1988/10/01 00:01 [medline]
PHST- 1988/10/01 00:00 [entrez]
AID - 10.1111/j.1399-6576.1988.tb02781.x [doi]
PST - ppublish
SO  - Acta Anaesthesiol Scand. 1988 Oct;32(7):535-40. doi: 
      10.1111/j.1399-6576.1988.tb02781.x.