PMID- 31422757
OWN - NLM
STAT- MEDLINE
DCOM- 20210201
LR  - 20210201
IS  - 1532-2750 (Electronic)
IS  - 1098-612X (Linking)
VI  - 22
IP  - 7
DP  - 2020 Jul
TI  - Plasma homocysteine concentration in privately owned healthy adult cats: 
      assessment of biological determinants and establishment of a reference interval.
PG  - 623-630
LID - 10.1177/1098612X19868549 [doi]
AB  - OBJECTIVES: The assessment of homocysteine status in diseased cats has indicated 
      high plasma concentrations in chronic kidney disease and yielded conflicting 
      results with respect to cardiovascular disorders. Previous investigations in 
      small populations of normal cats revealed greater-than-expected variability in 
      plasma homocysteine concentration. The purpose of this study was to determine 
      biological determinants and the reference interval (RI) of plasma homocysteine 
      concentration in the feline species, under strict pre-analytical conditions. 
      METHODS: In this prospective observational study, privately owned healthy adult 
      cats underwent a complete physical examination, urinalysis and blood testing, in 
      order to rule out any signs of disease. Plasma homocysteine concentration was 
      measured using high-performance liquid chromatography-tandem mass spectrometry. 
      RESULTS: Of 151 cats recruited, 30 cats were not included owing to abnormal 
      physical examination or fractious behaviour, and 30 cats were excluded based on 
      abnormalities on blood work or urinalysis. Plasma homocysteine concentrations 
      >28 micromol/l were associated with a dietary protein content >9.3 g/100 kcal 
      metabolisable energy. The RI for plasma homocysteine concentration was determined 
      to be 6.2-52.3 micromol/l. CONCLUSIONS AND RELEVANCE: Normal values for plasma 
      homocysteine concentration in cats have a wide RI, suggesting high 
      inter-individual variability. Whether some healthy cats exhibit impaired 
      homocysteine metabolism remains to be elucidated.
FAU - Drut, Amandine
AU  - Drut A
AUID- ORCID: 0000-0002-8700-6004
AD  - Department of Clinical Science, Oniris - Nantes Atlantic National College of 
      Veterinary Medicine, Food Science and Engineering, Nantes, France.
AD  - Nutrition, Physiopathology and Pharmacology Unit, Oniris - Nantes Atlantic 
      National College of Veterinary Medicine, Food Science and Engineering, Nantes, 
      France.
FAU - Soetart, Nicolas
AU  - Soetart N
AD  - Department of Biology, Pathology and Food Science, Oniris - Nantes Atlantic 
      National College of Veterinary Medicine, Food Science and Engineering, Nantes, 
      France.
FAU - Bertin, Carole
AU  - Bertin C
AD  - Department of Biochemistry and Genetics, University Hospital, Angers, France.
FAU - Le Corff, Emmanuelle
AU  - Le Corff E
AD  - Department of Clinical Science, Oniris - Nantes Atlantic National College of 
      Veterinary Medicine, Food Science and Engineering, Nantes, France.
FAU - Berder, Caroline
AU  - Berder C
AD  - Nutrition, Physiopathology and Pharmacology Unit, Oniris - Nantes Atlantic 
      National College of Veterinary Medicine, Food Science and Engineering, Nantes, 
      France.
AD  - Department of Biology, Pathology and Food Science, Oniris - Nantes Atlantic 
      National College of Veterinary Medicine, Food Science and Engineering, Nantes, 
      France.
FAU - Thorin, Chantal
AU  - Thorin C
AD  - Nutrition, Physiopathology and Pharmacology Unit, Oniris - Nantes Atlantic 
      National College of Veterinary Medicine, Food Science and Engineering, Nantes, 
      France.
FAU - Nguyen, Patrick
AU  - Nguyen P
AD  - Nutrition, Physiopathology and Pharmacology Unit, Oniris - Nantes Atlantic 
      National College of Veterinary Medicine, Food Science and Engineering, Nantes, 
      France.
FAU - Simard, Gilles
AU  - Simard G
AD  - Department of Biochemistry and Genetics, University Hospital, Angers, France.
FAU - Mallem, M Yassine
AU  - Mallem MY
AD  - Nutrition, Physiopathology and Pharmacology Unit, Oniris - Nantes Atlantic 
      National College of Veterinary Medicine, Food Science and Engineering, Nantes, 
      France.
LA  - eng
PT  - Journal Article
DEP - 20190819
PL  - England
TA  - J Feline Med Surg
JT  - Journal of feline medicine and surgery
JID - 100897329
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Animals
MH  - Cats/*blood
MH  - Chromatography, High Pressure Liquid
MH  - Diet/veterinary
MH  - Homocysteine/*blood
MH  - Prospective Studies
MH  - Reference Values
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - cobalamin
OT  - folate
OT  - kidney disease
EDAT- 2019/08/20 06:00
MHDA- 2021/02/02 06:00
CRDT- 2019/08/20 06:00
PHST- 2019/08/20 06:00 [pubmed]
PHST- 2021/02/02 06:00 [medline]
PHST- 2019/08/20 06:00 [entrez]
AID - 10.1177/1098612X19868549 [doi]
PST - ppublish
SO  - J Feline Med Surg. 2020 Jul;22(7):623-630. doi: 10.1177/1098612X19868549. Epub 
      2019 Aug 19.