PMID- 31423406 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 11 IP - 8 DP - 2019 Aug 11 TI - Venovenous Extracorporeal Membrane Oxygenation Therapy in Adults. PG - e5365 LID - 10.7759/cureus.5365 [doi] LID - e5365 AB - Extracorporeal membrane oxygenation (ECMO) therapy is used as supportive therapy for patients with respiratory failure, cardiac failure, and cardiopulmonary failure. Venovenous extracorporeal membrane oxygenation (VV-ECMO) is one subtype used for respiratory failure as a supportive treatment for critically ill patients. The principle behind it is that the membrane lung (oxygenator) is placed sequentially with the normal lungs rather than in parallel like with cardiopulmonary bypass, therefore, the lungs do not have to work as hard to oxygenate the blood. Then using a drainage cannula, blood is drained from the right atrium (RA) and after going through the membrane lung, the newly oxygenated blood is returned back to the RA. Because of this, there is enough systemic oxygen delivery to manage metabolism and preserve the airway even at lower tidal volume ventilation settings. With ventilator settings placed at lower tidal volume, there is less risk of barotrauma. This is a review article discussing VV-ECMO therapy with adult patients. It will also go into detail regarding its indications, contraindications, configurations, patient assessment, vascular access, and complications. FAU - Patel, Avani R AU - Patel AR AD - Internal Medicine, Northern California Kaiser Permanente, Fremont, USA. FAU - Patel, Amar R AU - Patel AR AD - Internal Medicine, Northern California Kaiser Permanente, Fremont, USA. FAU - Singh, Shivank AU - Singh S AD - Internal Medicine, Southern Medical University, Guangzhou, CHN. FAU - Singh, Shantanu AU - Singh S AD - Pulmonary Medicine, Marshall University School of Medicine, Huntington, USA. FAU - Munn, Nancy J AU - Munn NJ AD - Pulmonary Medicine, Veterans Affairs Medical Center, Huntington, USA. LA - eng PT - Journal Article PT - Review DEP - 20190811 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC6692097 OTO - NOTNLM OT - acute respiratory distress syndrome (ards) OT - age-adjusted oxygenation index OT - apss OT - barotrauma OT - extracorporeal membrane oxygenation (ecmo) OT - membrane lung OT - murray score OT - seldinger technique OT - semi-seldinger technique OT - venovenous extracorporeal membrane oxygenation (vv-ecmo) COIS- The authors have declared that no competing interests exist. EDAT- 2019/08/20 06:00 MHDA- 2019/08/20 06:01 PMCR- 2019/08/11 CRDT- 2019/08/20 06:00 PHST- 2019/08/20 06:00 [entrez] PHST- 2019/08/20 06:00 [pubmed] PHST- 2019/08/20 06:01 [medline] PHST- 2019/08/11 00:00 [pmc-release] AID - 10.7759/cureus.5365 [doi] PST - epublish SO - Cureus. 2019 Aug 11;11(8):e5365. doi: 10.7759/cureus.5365.