PMID- 31423677
OWN - NLM
STAT- MEDLINE
DCOM- 20201208
LR  - 20201214
IS  - 1468-3083 (Electronic)
IS  - 0926-9959 (Linking)
VI  - 34
IP  - 1
DP  - 2020 Jan
TI  - Characteristics of patients with bullous pemphigoid: comparison of classic 
      bullous pemphigoid to non-bullous pemphigoid.
PG  - 161-165
LID - 10.1111/jdv.15883 [doi]
AB  - BACKGROUND: Bullous pemphigoid (BP) is the most common subepidermal autoimmune 
      blistering disease. Patients occasionally present with a clinical picture of 
      pruritus/urticaria alone for months and do not even develop blisters over time. 
      Only few studies have investigated this subgroup of non-bullous pemphigoid (NBP). 
      OBJECTIVE: To evaluate the demographic and clinical characteristics of BP 
      patients with or without blisters at the time of diagnosis. METHODS: A 
      retrospective study based on the medical records of 115 BP patients. Collected 
      data included demographic characteristics, clinical presentation, treatment and 
      response to treatment. RESULTS: Thirty-six patients presented with 
      pruritus/urticaria (31.3%), and 79 presented with blisters (68.7%), with mean 
      ages of 77.5 and 76.0, respectively, at diagnosis and an equal female:male ratio. 
      The level of immunoglobulin E (IgE) was 4.1 times higher, and the mean blood 
      eosinophil count was significantly increased in the pruritus/urticaria group. 
      Remission rate at 3 months and relapse rate were similar between the groups. 
      Median follow-up period was 9 months (range 3-18). Only 23% of the patients with 
      pruritus/urticaria developed blisters. CONCLUSIONS: A significant number of BP 
      patients present without blisters. We found no significant epidemiological or 
      clinical differences from the classic BP patients aside from significantly 
      elevated IgE and blood eosinophil levels. Similar results in larger cohort 
      studies might be the foundation for a change in clinical protocols regarding the 
      diagnosis and recommended treatment for the elderly presenting with 
      pruritus/urticaria only.
CI  - (c) 2019 European Academy of Dermatology and Venereology.
FAU - Ben Mordehai, Y
AU  - Ben Mordehai Y
AD  - Department of Dermatology, Sheba Medical Center, Ramat Gan, Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Faibish, H
AU  - Faibish H
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Astman, N
AU  - Astman N
AD  - Department of Dermatology, Sheba Medical Center, Ramat Gan, Israel.
AD  - Israel Defense Forces Medical Corps, Ramat Gan, Israel.
FAU - Greenberger, S
AU  - Greenberger S
AD  - Department of Dermatology, Sheba Medical Center, Ramat Gan, Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Barzilai, A
AU  - Barzilai A
AD  - Department of Dermatology, Sheba Medical Center, Ramat Gan, Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Baum, S
AU  - Baum S
AD  - Department of Dermatology, Sheba Medical Center, Ramat Gan, Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
LA  - eng
PT  - Journal Article
DEP - 20190905
PL  - England
TA  - J Eur Acad Dermatol Venereol
JT  - Journal of the European Academy of Dermatology and Venereology : JEADV
JID - 9216037
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Blister/blood/diagnosis/etiology
MH  - Eosinophils
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Pemphigoid, Bullous/*complications/*diagnosis/therapy
MH  - Pruritus/blood/diagnosis/etiology
MH  - Retrospective Studies
MH  - Symptom Assessment
MH  - Urticaria/blood/diagnosis/etiology
EDAT- 2019/08/20 06:00
MHDA- 2020/12/15 06:00
CRDT- 2019/08/20 06:00
PHST- 2019/03/04 00:00 [received]
PHST- 2019/07/17 00:00 [accepted]
PHST- 2019/08/20 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2019/08/20 06:00 [entrez]
AID - 10.1111/jdv.15883 [doi]
PST - ppublish
SO  - J Eur Acad Dermatol Venereol. 2020 Jan;34(1):161-165. doi: 10.1111/jdv.15883. 
      Epub 2019 Sep 5.