PMID- 31425951
OWN - NLM
STAT- MEDLINE
DCOM- 20200212
LR  - 20200212
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 13
IP  - 5
DP  - 2019 Sep-Oct
TI  - Effects of vitamin D supplementation on circulatory YKL-40 and MCP-1 biomarkers 
      associated with vascular diabetic complications: A randomized, 
      placebo-controlled, double-blind clinical trial.
PG  - 2873-2877
LID - S1871-4021(19)30449-7 [pii]
LID - 10.1016/j.dsx.2019.07.047 [doi]
AB  - AIM: Diabetic patients predispose to vascular diseases such as nephropathy, and 
      retinopathy. Poor adherence to medical treatment and dietary recommendations in 
      uncontrolled diabetes leads to vascular damages. Vitamin D has been extensively 
      studied and found to be protective against diabetes mellitus. YKL-40 and Monocyte 
      chemoattractant protein-1 (MCP-1) are considered to exert crucial role in 
      diabetes and its complications. Therefore, this study was designed to investigate 
      effects of vitamin D supplementation on serum levels of YKL-40 and MCP-1 involved 
      in the development of diabetic complications. METHODS: For 12 weeks, 48 type 2 
      diabetic patients enrolled in the trial and randomly were divided into two groups 
      (n = 24 per group), receiving one of the following: 100 mug (4000 IU) vitamin D or 
      placebo. Before and after intervention, serumYKL-40, MCP-1, insulin, IL-6, TNF-alpha, 
      25- (OH) vitamin D and HbA1c were measured. RESULTS: Our results revealed that 
      serum levels of 25 (OH) vitamin D significantly increased in vitamin D group 
      (p < 0.001). Vitamin D supplementation also significantly reduced serum YKL-40 
      levels (-22.7 vs. -2.4 ng/ml; (p-value = 0.003)). There was a significant decline 
      in MCP-1 concentration in intervention group at the end of the study (-45.7 
      vs. -0.9 pg/ml; (p = 0.001)). Furthermore, there was a significant decrease in 
      IL-6, fasting insulin and HOMA-IR in intervention group after 3 months 
      supplementation. CONCLUSIONS: Daily vitamin D supplementation effectively reduced 
      circulatory YKL-40 and MCP-1 levels in patients with type-2 diabetes and vitamin 
      D deficiency. Vitamin D might contribute in reducing diabetic complications via 
      modulating YKL-40 and MCP-1 signaling pathways.
CI  - Copyright (c) 2019. Published by Elsevier Ltd.
FAU - Omidian, Mahsa
AU  - Omidian M
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Mahmoudi, Maryam
AU  - Mahmoudi M
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Javanbakht, Mohammad Hassan
AU  - Javanbakht MH
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Eshraghian, Mohammad Reza
AU  - Eshraghian MR
AD  - Department of Biostatistics, School of Public Health, Tehran University of 
      Medical Sciences, Tehran, Iran.
FAU - Abshirini, Maryam
AU  - Abshirini M
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Daneshzad, Elnaz
AU  - Daneshzad E
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Hasani, Hossein
AU  - Hasani H
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Alvandi, Ehsan
AU  - Alvandi E
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Djalali, Mahmoud
AU  - Djalali M
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic 
      address: Jalalikh@sina.tums.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20190729
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (CHI3L1 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chitinase-3-Like Protein 1)
RN  - 0 (Vitamins)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Adult
MH  - Biomarkers/*blood
MH  - Chemokine CCL2/*blood
MH  - Chitinase-3-Like Protein 1/*blood
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Angiopathies/*blood/drug therapy/etiology
MH  - Dietary Supplements
MH  - Double-Blind Method
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Vitamin D/*administration & dosage
MH  - Vitamin D Deficiency/blood/*drug therapy/physiopathology
MH  - Vitamins/administration & dosage
OTO - NOTNLM
OT  - Diabetic complications
OT  - Inflammation
OT  - Monocyte chemoattractant protein-1
OT  - Vitamin D
OT  - YKL-40
EDAT- 2019/08/20 06:00
MHDA- 2020/02/13 06:00
CRDT- 2019/08/20 06:00
PHST- 2019/06/30 00:00 [received]
PHST- 2019/07/29 00:00 [accepted]
PHST- 2019/08/20 06:00 [pubmed]
PHST- 2020/02/13 06:00 [medline]
PHST- 2019/08/20 06:00 [entrez]
AID - S1871-4021(19)30449-7 [pii]
AID - 10.1016/j.dsx.2019.07.047 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2019 Sep-Oct;13(5):2873-2877. doi: 
      10.1016/j.dsx.2019.07.047. Epub 2019 Jul 29.